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Cyclosporin A Produkt Beschreibung

Cyclosporin A Struktur
59865-13-3
CAS-Nr.
59865-13-3
Englisch Name:
Cyclosporin A
Synonyma:
CL285;Neoral;Atopica;s7481f1;Cipol N;Restasis;Lo-27400;ol27-400;Optimmune;sandimmun
CBNumber:
CB5163816
Summenformel:
C62H111N11O12
Molgewicht:
1202.61
MOL-Datei:
59865-13-3.mol

Cyclosporin A Eigenschaften

Schmelzpunkt:
148-151°C
Siedepunkt:
838.63°C (rough estimate)
alpha 
D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
Dichte
0.9913 (rough estimate)
Brechungsindex
1.6500 (estimate)
Flammpunkt:
87℃
storage temp. 
2-8°C
Löslichkeit
ethanol: 30 mg/mL
Aggregatzustand
solid
Farbe
white
Wasserlöslichkeit
Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
Merck 
14,2752
BRN 
3647785
InChIKey
PMATZTZNYRCHOR-CGLBZJNRSA-N
CAS Datenbank
59865-13-3(CAS DataBase Reference)
EPA chemische Informationen
Cyclosporin A(59865-13-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xn,F
R-Sätze: 45-60-22-40-36-20/21/22-11
S-Sätze: 53-45-36/37-24/25-22-26-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS-Nr. GZ4120000
HS Code  29419090
Giftige Stoffe Daten 59865-13-3(Hazardous Substances Data)
Toxizität LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
H362 Kann Säuglinge über die Muttermilch schädigen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Cyclosporin A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

White crystalline solid or powder.

Chemische Eigenschaften

White or almost white powder

Verwenden

prothrombogenic agent

Verwenden

Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.

Verwenden

An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Definition

ChEBI: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibiti n of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.

Trademarks

Gengraf (Abbott); Neoral (Novartis); Restasis (Allergan); Sandimmune (Novartis) [Names previously used: Cyclosporin A; Cyclosporin.].

Allgemeine Beschreibung

White prismatic needles (from acetone) or white powder.

Air & Water Reaktionen

Slightly water soluble .

Reaktivität anzeigen

Cyclosporin A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

SYMPTOMS: Symptoms of exposure to Cyclosporin A include hepatotoxicity, nephrotoxicity, hyperkalemia, hyperuricemia, convulsions, renal dysfunction, tremor, hirsutism, hypertension, gum hyperplasia, cramps, acne, headache, diarrhea, nausea, vomiting, abdominal discomfort, paresthesia, flushing, leukopenia, lymphoma, sinusitis and gynecomastia. In 2% or less of persons exposed, it has caused allergic reactions, anemia, anorexia, confusion, conjunctivitis, edema, fever, brittle fingernails, gastritis, hearing loss, hiccups, hyperglycemia, muscle pain, peptic ulcer, thrombocytopenia and tinnitus. Rare reactions include anxiety, chest pain, constipation, depression, hair breaking hematuria, joint pain, lethargy, mouth sores, myocardial infarction, night sweats, pancreatitis, pruritus, swallowing difficulty, tingling, upper gastrointestinal bleeding, visual disturbance, weakness and weight loss. It has caused kidney and liver damage. An increased susceptibility to infection may occur. Other symptoms include gastrointestinal disturbance, rashes and angioedema.

Brandgefahr

Flash point data for Cyclosporin A are not available; however, Cyclosporin A is probably combustible.

Sicherheitsprofil

Confirmed carcinogen producing Hodghn's dlsease. Experimental reproductive effects. Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: increased body temperature, cyanosis. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

mögliche Exposition

Cyclosporin A is a fungal metabolite; an amide immunosuppressant drug used in various surgeries.

Carcinogenicity

Cyclosporin A is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

Versand/Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Inkompatibilitäten

Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents such as hydrideds and active metals. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as such as phosphorus pent- oxide or thionyl chloride generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Waste disposal

t is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consider- ation applicable DEA, EPA, and FDA regulations. If possi- ble return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Verordnung (Regulations)

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Cyclosporin A is a prescription drug subject to specific labeling requirements.

Cyclosporin A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cyclosporin A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 359)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21714 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58

59865-13-3()Verwandte Suche:


  • Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem
  • ANTIBIOTIC S 7481F1
  • ANTIBIOTIC S 7481FI
  • CICLOSPORIN
  • CICLOSPORIN A
  • CYCLOSPORIN A
  • CYCLOSPORIN A, FUSARIUM SOLANI
  • CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM
  • CYCLOSPORINE
  • CYCLOSPORINE A
  • RAMIHYPHIN A
  • Cyclosporine, Trichoderma polysporum
  • Cyclosporin A USP26/EPIV
  • CYCLOSPORIN A, MOLECULAR BIOLOGYREAGENT
  • CyclosporinAfromFusariumsolani
  • CYCLOSPORINA(PATENTED-NOSUPPLY)
  • Cyclosporin A / B / C / D / H
  • CYCLOSPORIN USP
  • CYCLOSPORINE USP
  • Antibiotic S 7481F1, Cyclosporine
  • Cyclosporin A from Tolypocladium inflatum
  • Atopica
  • Neoral
  • Optimmune
  • Restasis
  • Cyclosprin
  • Lo-27400
  • Sandimmum(e)
  • Ciclosporin, RaMihyphin A, OL 27-400, CyA, S 7481F1
  • Cyclosporin A (Cyclosporine A)
  • Cyclosporin A solution
  • Cyclosporin A, >=98%
  • MEDIABAG SACHETS FOR 450 ML BPW
  • CL285
  • NSC 290193
  • Cyclosporin A, 99%, an immunosuppressive agent
  • CsA, Cyclosporin A
  • ol27-400
  • s7481f1
  • sandimmun
  • sandimmune
  • 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.
  • 30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • Cipol N
  • Neoplanta
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,
  • (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • Cicloporin A
  • Cyclospori
  • Cyclosporin A,Antibiotic S 7481F1, Cyclosporine
  • CYCLOSPORIN A (ANTIBIOTIC S 7481FI)
  • Cyclosporine (50 mg)
  • Cyclosporin A(Antibiotic S 7481F1)
  • Ciclosporin API
  • Cyclosporine-d4/ Cyclosporin A-d4
  • oil solution
  • CiclosporinOralSolution
  • Cyclosporine IMpurity-A
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