3-Chlor-4-(2-propenyloxy)benzol-essigsäure
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- CAS-Nr.
- 22131-79-9
- Bezeichnung:
- 3-Chlor-4-(2-propenyloxy)benzol-essigsäure
- Englisch Name:
- ALCLOFENAC
- Synonyma:
- Argun;w7320;Epinal;Mervan;W 7320;MY 101;Neosten;Neoston;Zumaril;Reufenac
- CBNumber:
- CB5491171
- Summenformel:
- C11H11ClO3
- Molgewicht:
- 226.66
- MOL-Datei:
- 22131-79-9.mol
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3-Chlor-4-(2-propenyloxy)benzol-essigsäure Eigenschaften
- Schmelzpunkt:
- 90-91°C
- Siedepunkt:
- 324.6°C (rough estimate)
- Dichte
- 1.2401 (rough estimate)
- Brechungsindex
- 1.4530 (estimate)
- storage temp.
- Refrigerator
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- pka
- pKa 10.3 (Uncertain)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Pale Yellow
- Wasserlöslichkeit
- 13.1mg/L(25 ºC)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Toxizität |
LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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3-Chlor-4-(2-propenyloxy)benzol-essigsäure Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White to Pale Yellow Solid
Verwenden
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r
sh.
Weltgesundheitsorganisation (WHO)
Alclofenac, a phenylacetic acid derivative with analgesic,
antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment
of rheumatic disorders. In the late 1970s its use was associated with a high
incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the
withdrawal of the drug, in some cases voluntarily, from several countries. In others
registration has been refused. The reported mutagenic potential has been
questioned by some investigators and the drug remains on the market in at least
three countries with highly evolved regulatory authorities.
Dosage
Alclofenac when used at 3 g/d in the treatment of rheumatoid arthritis is as effective
as 75 mg/d of indomethacin with fewer adverse effects. In the treatment of osteoarthritis 1500 mg/d is as effective and is better tolerated than 300 mg/d of phenylbutazone. Alclofenac has been withdrawn from the market in the United Kingdom because of skin rash and
vasculitis (blood vessel inflammation).
3-Chlor-4-(2-propenyloxy)benzol-essigsäure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Chlor-4-(2-propenyloxy)benzol-essigsäure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 48)Lieferanten
22131-79-9(3-Chlor-4-(2-propenyloxy)benzol-essigsäure)Verwandte Suche:
- 4-(Allyloxy)-3-chlorobenzeneacetic acid
- 2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
- 2-(3-chloro-4-prop-2-enoxy-phenyl)ethanoic acid
- 2-(4-allyloxy-3-chloro-phenyl)acetic acid
- 3-chloro-4-(2-propenyloxy)-benzeneaceticaci
- 3-chloro-4-(2-propenyloxy)benzeneaceticacid
- 4-allyloxy-3-chlorophenyl-aceticaci
- Acetic acid, [4-(allyloxy)-3-chlorophenyl]-
- Alclophenac
- Alcorenac
- Allopydin
- Argun
- Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-
- Epinal
- Kyselina 4-allyloxy-3-chlorfenyloctova
- kyselina4-allyloxy-3-chlorfenyloctova
- Medifenac
- Mervan
- Neosten
- Neoston
- Prinalgin
- Reufenac
- W 7320
- w7320
- Zumaril
- 3-Chloro-4-(2-propen-1-yloxy)benzeneacetic Acid
- Aclofenac
- MY 101
- ALCLOFENAC
- (4-ALLYLOXY-3-CHLORO-PHENYL)-ACETIC ACID
- [3-Chloro-4-(allyloxy)phenyl]acetic acid
- 3-Chloro-4-(2-propenyloxy)benzeneacetic acid
- Benzeneacetic acid, 3-chloro-4-(2-propen-1-yloxy)-
- BRN 2116510
- 22131-79-9
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
