oelsure, Monoester mit Glycerin

Glyceryl monooleate Struktur
25496-72-4
CAS-Nr.
25496-72-4
Bezeichnung:
oelsure, Monoester mit Glycerin
Englisch Name:
Glyceryl monooleate
Synonyma:
GLYCEROL MONOOLEATE;peceol;1-OLEOYL-RAC-GLYCEROL;1-MONOOLEIN;E 496;s1096;s1097;OP 85;SP 40;SP 65
CBNumber:
CB5757259
Summenformel:
C21H40O4
Molgewicht:
356.54
MOL-Datei:
25496-72-4.mol

oelsure, Monoester mit Glycerin Eigenschaften

Schmelzpunkt:
35-37 °C
Siedepunkt:
449.35°C (rough estimate)
Dichte
0.96 g/cm3 (25 ºC)
Brechungsindex
1.4626 (589.3 nm 40℃)
FEMA 
2526 | GLYCERYL MONOOLEATE
storage temp. 
−20°C
Löslichkeit
chloroform: 50 mg/mL, clear, colorless
Wasserlöslichkeit
<3.57mg/L(30 ºC)
Stabilität:
Hygroscopic
InChI
InChI=1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-
InChIKey
RZRNAYUHWVFMIP-KTKRTIGZSA-N
SMILES
O(C(=O)CCCCCCC/C=C\CCCCCCCC)CC(CO)O
CAS Datenbank
25496-72-4(CAS DataBase Reference)
EPA chemische Informationen
Glyceryl monooleate (25496-72-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  1
3
HS Code  3822000002
Giftige Stoffe Daten 25496-72-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

oelsure, Monoester mit Glycerin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Glyceryl monooleate (GMO), generally referred to as monoolein (MO), is FDA approved amphiphilic lipid that is widely used during the synthesis of cubosomes. Glyceryl monooleate is a waxy material, but its physical form is dependent on the content of di- and triglyceride. GMO is a polar unsaturated monoglyceride that can self-assemble in water into bicontinuous cubic structures. The amphiphilic chemical structure of GMO with hydrophilic polar head (hydroxyl groups) and hydrophobic chains in the tail facilitates H-bond formation with water. GMOs are classified as GRAS (generally recognized as safe) due to their biodegradability, biocompatibility, and minimal toxicity. The biodegradability was attributed to the lipolysis of GMOs in different tissues via esterase activity. The GMO-based systems, especially bicontinuous cubic and hexagonal LC phases, were highly reported as promising drug delivery. Thanks to their unique features, which include their minimal toxicity, prolonged release rate, and thermodynamic stability upon exposure to excess water.

Verwenden

93% 1-Oleoyl, 7% 2-oleoyl

Definition

An antifog agent and dispersant.

Vorbereitung Methode

Glyceryl monooleate is prepared by the esterification of glycerol with fatty acids, chiefly oleic acid. As the fatty acids are not pure substances, but rather a mixture of fatty acids, the product obtained from the esterification will contain a mixture of esters, including stearic and palmitic. Di- and triesters may also be present. The composition and, therefore, the physical properties of glyceryl monooleate may thus vary considerably from manufacturer to manufacturer; e.g. the melting point may vary from 10–35°C.

Pharmazeutische Anwendungen

Glyceryl monooleate is a polar lipid that swells in water to give several phases with different rheological properties. It is available in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the self-emulsifying grade containing about 5% of an anionic surfactant.
The nonemulsifying grade is used in topical formulations as an emollient and as an emulsifying agent for water-in-oil emulsions. It is also a stabilizer for oil-in-water emulsions. The self-emulsifying grade is used as a primary emulsifier for oil-in-water systems.
Glyceryl monooleate gels in excess water, forming a highly ordered cubic phase that can be used to sustain the release of various water-soluble drugs.It is also the basis of mucoadhesive drug delivery systems.
Glyceryl monooleate is reported to enhance transdermal and buccal penetration.

Sicherheitsprofil

When heated to decomposition it emits acrid smoke and irritating fumes.

Sicherheit(Safety)

Glyceryl monooleate is used in oral and topical pharmaceutical formulations and is generally regarded as a relatively nonirritant and nontoxic excipient.

Lager

Glyceryl monooleate should be stored in an airtight container, protected from light in a cool, dry place.

Inkompatibilitäten

Glyceryl monooleate is incompatible with strong oxidizing agents. The self-emulsifying grade is incompatible with cationic surfactants.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, oral powder, oral tablets; creams, controlled-release transdermal films). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

oelsure, Monoester mit Glycerin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


oelsure, Monoester mit Glycerin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 174)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5987 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5872 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21667 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8820 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39916 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29823 58

25496-72-4(oelsure, Monoester mit Glycerin)Verwandte Suche:


  • DL-ALPHA-MONOOLEIN
  • DELTA 9 CIS MONOOLEIN
  • GLYCERYL CIS-9-OCTADECENOATE
  • GLYCEROL ALPHA-MONOOLEATE
  • GLYCEROL-1-MONOOLEATE
  • oleic acid, monoester with glycerol
  • 9-Octadecenoic acid (9Z)-, monoester with 1,2,3-propanetriol
  • CIS-9-OCTADECENYLGLYCEROL
  • Glycerinmonooleat
  • 9-Octadecenoic acid(Z)-,2,3-dihydoxypropyl ester
  • di-alpha-monoolein
  • rac-(2R*)-1-O-Oleoylglycerol
  • rac-(2R*)-3-(Oleoyloxy)-1,2-propanediol
  • rac-(2R*)-3-(Oleoyloxy)propane-1,2-diol
  • rac-(2R*)-Glycerin 1-oleate
  • rac-(R*)-3-(Oleoyloxy)-1,2-propanediol
  • (Z)-9-Octadecenoic acid,monoester with 1,2,3-propanetriol
  • Glycerol monooleate 10g [25496-72-4]
  • Aids166759
  • Aids-166759
  • Glyceryl Monooleate 40% (500 mg)
  • Glyceryl Monooleate 90% (250 mg)
  • Alkamuls STO
  • Atlox 4885
  • Atmer 106
  • Crill 45
  • Crill 45R
  • Dehymuls STO
  • E 496
  • Emasol O 30V
  • EMS 85
  • 9-Octadecenoicacid(Z)-,monoesterwith1,2,3-propanetriol
  • adchemgmo
  • ajaxgmo
  • aldo40
  • aldomo-fg
  • dur-em204
  • emcolo
  • emeryoleicacidester2221
  • emrite6009
  • glycerinemonooleate
  • glycerinmonooleate
  • glycerol,1-mono(9-octa-decenoate)
  • gmo8903
  • harowaxl9
  • loxiolg10
  • monoglyceryloleate
  • mono-olei
  • monooleoylglycerol
  • oleicacidglycerolmonoester
  • oleicacidmonoglyceride
  • oleoylglycerol
  • oleylmonoglyceride
  • olicine
  • rikemalo71d
  • rikemalol100
  • s1096
  • s1096r
Copyright 2019 © ChemicalBook. All rights reserved