Bunitrolol

Bunitrolol  Struktur
34915-68-9
CAS-Nr.
34915-68-9
Englisch Name:
Bunitrolol
Synonyma:
Bunitrolol;dl-Bunitolol;2-nitrilo-n-tert-butylphenoxypropanolamine;1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol;3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano;1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol;o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril;o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile;2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile;1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
CBNumber:
CB5947087
Summenformel:
C14H20N2O2
Molgewicht:
248.32
MOL-Datei:
34915-68-9.mol

Bunitrolol Eigenschaften

Schmelzpunkt:
163-165 °C
Siedepunkt:
414.2±35.0 °C(Predicted)
Dichte
1.09±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
Löslichkeit
Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly, Sonicated)
Aggregatzustand
Solid
pka
13.76±0.20(Predicted)
Farbe
Colourless to Pale Yellow Sticky Oil

Sicherheit

Bunitrolol Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

St resson,Boehringer Ingelheim,Boehringer Ingelheim,1976

Manufacturing Process

Epichlorohydrin and 2-cyanophenol are first reacted to give 1-(2- cyanophenoxy)-2,3-epoxypropane.
15 g (0.085 mol) of 1-(2-cyanophenoxy)-2,3-epoxy propane were dissolved in 100 ml of ethanol and 18.6 g (0.255 mol) of t-butylamine were added thereto. After standing for 1 hour at room temperature, the solution was heated at 60°-70°C for 2 hours after which the volatile constituents were distilled off in vacuo. The residue was digested with dilute HCl, and the insoluble constituents were vacuum filtered off. Then the filtrate was made alkaline with NaOH and the precipitating base was taken up in ether. After the ether solution had been dried over MgSO4, the ether was distilled off and the residue was dissolved in ethanol and by addition of ethereal HCl, the hydrochloride was precipitated there from in crystalline form which after recrystallization from ethanol with an addition of ether gave9.8 g of 1-(2- cyanophenoxy)-2-hydroxy-3-t-butylamino propane hydrochloride having a melting point of 163°-165°C.

Therapeutic Function

Antianginal

Bunitrolol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bunitrolol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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34915-68-9()Verwandte Suche:


  • Bunitrolol
  • 1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
  • 1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol
  • 1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol
  • Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-
  • dl-Bunitolol
  • 2-nitrilo-n-tert-butylphenoxypropanolamine
  • 3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano
  • o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril
  • 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyloxy]benzonitrile
  • o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile
  • 2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile
  • 2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-benzonitril
  • 34915-68-9
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