Alectinib
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- CAS-Nr.
- 1256580-46-7
- Englisch Name:
- Alectinib
- Synonyma:
- Alecensa;Alecitinib;Alectinib (CH5424802);AF-802;CS-217;canna*;RG-7853;alectinb;Alectinib;CH5424802
- CBNumber:
- CB62534680
- Summenformel:
- C30H34N4O2
- Molgewicht:
- 482.62
- MOL-Datei:
- 1256580-46-7.mol
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Alectinib Eigenschaften
- Schmelzpunkt:
- 274-276°C
- Siedepunkt:
- 722.5±60.0 °C(Predicted)
- Dichte
- 1.28
- storage temp.
- -20°
- Löslichkeit
- Soluble in DMSO (up to 5 mg/ml with warming).
- Aggregatzustand
- solid
- pka
- 13.70±0.40(Predicted)
- Farbe
- White
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenität |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H373 |
Kann die Organe schädigen bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P314 |
Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Alectinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Alectinib is another selective ALK inhibitor that is able to overcome resistance
mutations from prior crizotinib exposure [38].
Chemische Eigenschaften
White to Off-White Solid
Verwenden
CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. CH5424802 have been cl
inically evaluated for the treatment of patients with ALK-driven tumors.
Indications
Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.
Definition
ChEBI: An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydr
chloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.
Alectinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Alectinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 306)Lieferanten
- AF-802
- CH-5424802/RG-7853
- Alectinib
- AF-802,RG-7853
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802)
- CH5424802-alectinib
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
CH5424802
- CH5424802, Alectinib, AF802
- 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
- 9-ETHYL-6,6-DIMETHYL-8-(4-MORPHOLINOPIPERIDIN-1-YL)-11-OXO-6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE
- CH5424802
- AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, ALECTINIB; BRAND NAME: ALECENSA
- brand name: Alecensa
- RO 5424802
- RO5424802
- RO5424802, Alectinib
- RG-7853
- AF-802; CH 5424802; CH-5424802; AF802; AF 802
- alectinb
- CS-217
- Alectinib free base
- 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
- 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
- 9-Ethyl-6,6-dimethyl-8-(4-morpholino-1-piperidyl)-11-oxo-5H-benzobcarbazole-3-carbonitrile
- Alectinib USP/EP/BP
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib
- Alectinib (AF-802, CH-5424802, RO-5424802, Alecensa)
- canna*
- Alectinib (CH5424802)
- Alecensa
- Alecitinib
- Elle, on behalf of,
- Alectinib free base
- 1256580-46-7
- Anti-cancer&immunity
- Inhibitors
- API
- API
