Chlorprothixene

Chlorprothixene Struktur
113-59-7
CAS-Nr.
113-59-7
Englisch Name:
Chlorprothixene
Synonyma:
CPX;CPO;n714;CPOX;mk184;N 714;n714c;Paxyl;MK 184;N 714C
CBNumber:
CB6361448
Summenformel:
C18H18ClNS
Molgewicht:
315.86
MOL-Datei:
113-59-7.mol

Chlorprothixene Eigenschaften

Schmelzpunkt:
97-98°
Siedepunkt:
160 °C(Press: 0.04 Torr)
Dichte
1.1048 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
DMSO : 33.33 mg/mL (105.52 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
Aggregatzustand
powder to crystal
pka
pKa 8.4(H2O) (Uncertain)
Farbe
White to Orange to Green
Wasserlöslichkeit
385.8ug/L(22.5 ºC)
Stabilität:
Hygroscopic
NIST chemische Informationen
Chlorprothixene(113-59-7)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2934.99.3000
Giftige Stoffe Daten 113-59-7(Hazardous Substances Data)
Toxizität LD50 oral in rabbit: 182mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H336 Kann Schläfrigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Schläfrigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
Sicherheit

Chlorprothixene Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.

Verwenden

Chlorprothixene has an antipsychotic and sedative action. It has expressed antiemetic activity. It is used in various psychoses, schizophrenia, reactive and neurotic depression with prevalent anxious symptomatology, and in conditions of excitement associated with fear and stress. It may be used in small doses as a sedative agent in neurosis.

Environmental Fate

Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.

Chlorprothixene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlorprothixene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 183)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58

113-59-7()Verwandte Suche:


  • (3E)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
  • (alpha-2-chloro-9-omega-dimethylamino-propylamine)thioxanthene
  • 2-chloro-n,n-dimethylthioxanthene-delta(sup9),gamma-propylamine
  • 2-Chloro-N,N-dimethylthioxanthene-delta9, gamma-propylamine
  • 3-(2-chloro-9H-thioxanthen-9-ylidene)-N-,N-dimethyl-1-propanamine
  • 3-(2-chloro-9h-thioxanthen-9-ylidene)-n,n-dimethyl-1-propanamine
  • 9H-Thioxanthene, 1-propanamine deriv.
  • 9H-thioxanthene,1-propanaminederiv.
  • alpha-2-chloro-10-(3-dimethylaminopropylidene)-thiaxanthene
  • alpha-Chlorprothixene
  • Chloroprothixene
  • Chlorprothixen
  • Chlorprothixine
  • Chlorprotixen
  • Chlorprotixene
  • Chlorprotixine
  • Chlothixen
  • cis-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
  • cis-Chlorprothixene
  • CPX
  • gamma-propylamine,2-chloro-n,n-dimethyl-thioxanthene-delta(sup9
  • Iaractan
  • MK 184
  • mk184
  • N 714
  • N 714C
  • n#714trans
  • n714
  • n714c
  • n-dimethyl-3-(2-chloro-9h-thioxanthen-9-ylidene)-(z)-1-propanamin
  • Paxyl
  • Rentovet
  • Ro 4-0403
  • ro4-0403
  • Ro-4-04033
  • Tactaran
  • Taractan
  • Tarasan
  • Thioxanthene-delta9, gamma-propylamine, 2-chloro-N,N-dimethyl-
  • Thioxanthene-delta9,gamma-propylamine, 2-chloro-N,N-dimethyl-, (Z)-
  • thioxanthene-Δ9,γ-propylamine,2-chloro-N,N-dimethyl-,(Z)-
  • trans-2-chloro-9-(3-dimethylaminopropylidene)thiaxanthene
  • Traquilan
  • Trictal
  • Truxal
  • Truxaletten
  • Truxil
  • Vetacalm
  • TARDAN
  • 3-(2-chlorothioxanthen-9-ylidene)-n,n-dimethyl-propan-1-amine
  • CHLORPROTHIXENE
  • 2-chloro-3-(dibenzo(b,e)thiin-10-ylidene)propyldimethylamine
  • Chlorthiaxanthen
  • 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (3Z)-
  • Chlorprothixene HCI
  • Cloxan
  • (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
  • ANTI-CPO (N-TERM) antibody produced in rabbit
Copyright 2019 © ChemicalBook. All rights reserved