Methyllithium

Methyllithium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R12:Hochentzündlich.
R15:Reagiert mit Wasser unter Bildung hochentzündlicher Gase.
R17:Selbstentzündlich an der Luft. Spontaneously flammable in air.
R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S43:Zum Löschen . . . (vom Hersteller anzugeben) verwenden (wenn Wasser die Gefahr erhöht, anfügen: "Kein Wasser verwenden").
S30:Niemals Wasser hinzugießen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.

Chemische Eigenschaften

Methyllithium is a colorless to yellowish solution, It is insoluble in hydrocarbon solvents although propyllithium and the higher homologues are miscible in hydrocarbons. Methyllithium is soluble in diethyl ether to about 6% by weight at room temperature (with or without lithium bromide) and is a little less soluble in tetrahydrofuran. Cooling of these solutions produces clear, colorless crystals of methyllithium etherate. Methyllithium is stable to about 200°C, at which temperature it disproportionates to dilithiomethane and methane.

Verwenden

There are no significant industrial uses of methyllithium, but it is widely used in the laboratory in Grignard type reactions.
Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.

synthetische

Methyllithium is produced industrially by the reaction of methyl chloride or methyl bromide with lithium metal dispersion in diethyl ether. The reaction with methyl chloride yields a solution of methyllithium and a precipitate of lithium chloride which may be readily separated. When methyl bromide is used, the lithium bromide byproduct remains in solution and complexes with the methyllithium. This reduces the reactivity of the methyllithium and, in certain cases, affects its usefulness. On the other hand, the less reactive complex is more stable in diethyl ether. Methyllithium produced from methyl chloride contains only about 0.3 % lithium chloride in a 5 % solution in diethyl ether. It is more reactive than the lithium bromide complex, but decomposes at the rate of 1 % of the contained methyllithium per year (that is 5.00 % solution goes to 4.95 %) at room temperature. The decomposition by ether cleavage results in methane and ethylene formation which increases the pressure in the container on long storage. Methyllithium can be prepared easily in tetrahydrofuran but it has a half-life of only about 2 days at room temperature due to solvent cleavage.

Application

Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (?)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (?)-sparteine as a chiral ligand.

Hazard

Flammable, dangerous fire and explosionrisk, self-ignites in air.

Methyllithium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methyllithium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5601	58

917-54-4(Methyllithium)Verwandte Suche:

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• METHYLLITHIUM
• LITHIUM METHYL
• MethyllithiumcomplexedwithlithiumbromideinethyletherMc
• METHYLLITHIUM SOLUTION, ~5 % IN DIETHYL ETHER
• METHYLLITHIUM SOL., ~1 M IN CUMENE/THF
• methyl-lithiu
• MethyllithiuM, 3% solution in 2-MeTHF/cuMene, AcroSeal
• MethyllithiuM in ether 1.6M
• Lithium methide
• MethyllithiuM, 1.3M solution in diethyl ether
• MethyllithiuM, 1.6M solution in diethyl ether, J&KSeal
• MethyllithiuM solution 3% in 2-Methyltetrahydrofuran/cuMene
• MethyllithiuM, 1.6 M in Diethyl ether, SpcSeal
• MethyllithiuM solution 3.1 M in diethoxyMethane
• MethyllithiuM lithiuM broMide coMplex, 2.2 M solution in diethyl ether, SpcSeal
• Methyllithium, Low Chloride, 1.6M Solution in Diethyl Ether (+/- 5% w/v)
• METHYLLITHIUM, 2.5M SOLUTION IN DIETHOX&
• METHYLLITHIUM, 1.6M SOLUTION IN DIETHYLETHER
• 1-2MinEther
• Lowhalide
• Methyllithium,complexedwithlithiumbromideinethylether(1.5M)
• methyllithium, 1-2m in ether
• methyllithium, 1-2m in ether, packaged under argon in resealable chemseal
• Methyllithium, 1-2M in ether, packaged under Argon in resealable ChemSealTM bottles
• Methyllithium (2.8% in Ethyl Ether, ca. 1.0mol/L)
• Methyllithium, 1.6 M solution in diethyl ether (± 5% w/v)
• Methyllithium1.6 M sol. in diethyl ether (± 5% w/v)AcroSeal§3
• Methyllithium, 1-2M in ether, packaged under Argon in resealable ChemSeal^t bottles
• Methyllithium,1.6 M sol. in diethyl ether (±5% w/v)
• Lithium methanide, MeLi
• Methyllithium3.0M
• Methyllithium, 1-2M in Ether, Packaged Under Argon in Resealable Chemseal Bottles
• Methyllithium, 1M in 2-Methyltetrahydrofuran
• Methyllithium solution,Lithium methanide, MeLi
• Methy-Lithium
• Methyllithium, 1.6 M sol. in diethyl ether (± 5% w/v), AcroSeal
• Methyl LithiuM 1.6Mol
• MethyllithiuM (ca. 3-5% in Ethyl Ether, ca. 1-2Mol/L)
• METHYL LITHIUM, 3M in diethoxymethane, (7-9 wt %)
• Methyllithium,8% in Diethoxymethane (DEM)(3M)
• Methyllithium ISO 9001：2015 REACH
• Methyllithium Lithium Iodide Complex 1.6M In DEE
• METHYLLITHIUM 1.6M IN DEE / 1.9 IN CYCLOPENTYL METHYL ETHER
• MELI
• LITHIUM METHANIDE
• Methyllithium lithium bromide complex solution
• Methyllithium solution
• Methyl lithium 1.6 M in DEE
• Methyllithium(1.6mol/LinTHF)
• MethyllithiuM Impurity
• 917-54-4
• 917-57-4
• CH3Li
• CH3LiBrLi
• CH3Li8729LiBr
• Alkyl
• Typical Metal Compounds
• Li (Lithium) Compounds