Evodiamine
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- CAS-Nr.
- 518-17-2
- Englisch Name:
- Evodiamine
- Synonyma:
- Isoevodiamine;C09187;Vodiamine;EVODIAMINE;Cornishine;d-Evodiamine;Dogwood base;EVODIAMINE 98%;Evodiamine.p.e;Evodiamine std.
- CBNumber:
- CB7344026
- Summenformel:
- C19H17N3O
- Molgewicht:
- 303.36
- MOL-Datei:
- 518-17-2.mol
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Evodiamine Eigenschaften
- Schmelzpunkt:
- 278°
- alpha
- D15 +352° (acetone); D +440° (chloroform)
- Siedepunkt:
- 444.29°C (rough estimate)
- Dichte
- 1.1684 (rough estimate)
- Brechungsindex
- 1.5900 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- Soluble in DMSO (up to 5 mg/ml).
- Aggregatzustand
- Off-white to light yellow solid.
- pka
- 17.27±0.20(Predicted)
- Farbe
- Yellow
- Geruch (Odor)
- Odorless
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- InChIKey
- TXDUTHBFYKGSAH-UHFFFAOYSA-N
- LogP
- 3.888 (est)
- CAS Datenbank
- 518-17-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| HS Code |
29339900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Evodiamine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White powder
Verwenden
A chemical extracted from Evodia plants, and has been shown to reduce fat uptake.
Anticancer Research
The fruit of Evodia rutaecarpa Benth. is a standout among the most prominent andmultipurpose herbs utilized in China for pharmacological application (Fei et al.2003). Phytochemical analysis demonstrated that evodiamine, an indole alkaloid,exists in elevated amounts in Chinese herb evodia. This has wide-ranging biologicalactivities with vasodilatory, anti-obesity, anticancer, and anti-inflammatoryeffects (Jiang and Hu 2009). Evodiamine represses PDGF-BB-induced vascularsmooth muscle cell proliferation in a dose-dependent manner. It inhibits cell cycleprogression by suppressing the activation of p38 and Erk/MAPK pathway andameliorates ROS generation (Yang et al. 2008b; Heo et al. 2009; Yang et al. 2013).Restraint of mitogenesis and p38/p Erk action may fill in as the molecular basis forthe capacity of evodiamine. Evodiamine causes continued initiation of Erk/MAPKsignaling pathway in 3T3-L1 and essential preadipocytes prompting a potentinhibitory impact for adipogenesis (Wang et al. 2008). The consequence of thisinvestigation showed that evodiamine hindered vascular smooth muscle cell(VSMC) multiplication by stifling cell cycle movement, p38 MAPK and Erk 1/2enactment, and generation of ROS. Moreover, evodiamine offers the potential oftreating cardiovascular infections connected with the strange expansion of vascularsmooth muscle cells.
Evodiamine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Evodiamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 440)Lieferanten
518-17-2()Verwandte Suche:
- EVODIAMINE 10% PLANT EXTRACT
- EVODIAMINE 98%
- EVODIAMINE 20% PLANT EXTRACT
- EVODIAMINE 5% PLANT EXTRACT
- Evodiamine std.
- EVODIAMINE
- 8,13,13b,14-Tetrahydro-14-methylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
- Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (S)-
- Indolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-
- 8,13,13b14-Tetrahydro-14-Methlindolo[23:3,4]Pyrido[2,1-b]Quinazolin-5-[7H]-One
- EvodiaMine(IsoevodiaMine)
- 8,13,13b,14-tetrahydro-14-methyl-,(S)-
- Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
- Evodia rutaecarpa E.P.
- [13bS,(+)]-8,13,13b,14-Tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
- [13bS,(+)]-8,13,13b,14-Tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazoline-5(7H)-one
- d-Evodiamine
- C09187
- Evodiamine.p.e
- EvodiaMine, froM TetradiuM ruticarpuM
- Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
- Evodiamine
8,13,13b,14-Tetrahydro-14-methylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
- Evodiamine, 98%, from Evodia rutaecarpa (Juss.) Benth.
- High Quality Natural Evodia Rutaecarpa Extract Evodiamine
- Evodiamine USP/EP/BP
- Evodiamine 518-17-2
- Evodiamine, 98%, from Tetradium ruticarpum
- Isoevodiamine
- Dogwood base
- Cornishine
- (S)-14-methyl-7,8,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one
- Vodiamine
- Evodiamine 98%min
- 518-17-2
- C19H17N3O
- Herb extract
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Plant extracts
- plant extract
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Vanilloid/TRPV channel
- Inhibitors
- Alkaloids
- 518-17-2
