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(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Produkt Beschreibung

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Struktur
846589-98-8
CAS-Nr.
846589-98-8
Englisch Name:
(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
Synonyma:
LORCASERIN HCL;(R)-1H-3-BENZAZEPINE;Lorcaserin hydrochloride;R Lorcaserin hydrochloride;Thiosildenafil Solution, 100ppm;Lorcaserin (hydrochloride) (CRM);lorcaserin hydrochloride (APD-356);Lorcaserin Hydrochloride (>50% ee);Green Card mianserin hydrochloride;(1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CBNumber:
CB82451004
Summenformel:
C11H15Cl2N
Molgewicht:
0
MOL-Datei:
846589-98-8.mol

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Eigenschaften

Sicherheit

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.

Originator

Pharmaceuticals (United States)

Verwenden

Anti-obesity (activate 5-HT2creceptor).

Definition

ChEBI: A hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug.

Trademarks

Belviq

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 148)Lieferanten
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Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
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Henan DaKen Chemical CO.,LTD.
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
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Jinan Jianfeng Chemical Co., Ltd
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Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3195 58
GIHI CHEMICALS CO.,LIMITED
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  • R Lorcaserin hydrochloride
  • lorcaserin hydrochloride (APD-356)
  • (R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride
  • Lorcaserin Hydrochloride (>50% ee)
  • 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-Methyl-, hydrochloride (1:1), (1R)-
  • Green Card mianserin hydrochloride
  • (R)-1H-3-BENZAZEPINE
  • Thiosildenafil Solution, 100ppm
  • Lorcaserin hydrochloride, 98%, a selective full agonist of human 5-HT2C receptor
  • Lorcaserin (hydrochloride) (CRM)
  • (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
  • LORCASERIN HCL
  • Lorcaserin hydrochloride
  • (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
  • (1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  • 846589-98-8
  • 646202-80-0
  • 616202-80-0
  • -
  • 5-HT 2c receptor agonist
  • Inhibitors
  • APIs
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