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(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 구조식 이미지
카스 번호:
846589-98-8
상품명:
(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
동의어(영문):
LORCASERIN HCL;(R)-1H-3-BENZAZEPINE;Lorcaserin hydrochloride;R Lorcaserin hydrochloride;Thiosildenafil Solution, 100ppm;Lorcaserin (hydrochloride) (CRM);lorcaserin hydrochloride (APD-356);Lorcaserin Hydrochloride (>50% ee);Green Card mianserin hydrochloride;(1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CBNumber:
CB82451004
분자식:
C11H15Cl2N
포뮬러 무게:
0
MOL 파일:
846589-98-8.mol

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 속성

안전

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE C화학적 특성, 용도, 생산

개요

In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.

Originator

Pharmaceuticals (United States)

용도

Anti-obesity (activate 5-HT2creceptor).

정의

ChEBI: A hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug.

상표명

Belviq

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품


(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 공급 업체

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