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Bisoprolol fumarate Produkt Beschreibung

Bisoprolol fumarate Struktur
104344-23-2
CAS-Nr.
104344-23-2
Englisch Name:
Bisoprolol fumarate
Synonyma:
EMCOR;SOPROL;ZEBETA;ISOTEN;CONCOR;Azopsin;Well-bi;Seafuri;MONOCOR;Bisotate
CBNumber:
CB8371980
Summenformel:
C22H35NO8
Molgewicht:
441.52
MOL-Datei:
104344-23-2.mol

Bisoprolol fumarate Eigenschaften

Schmelzpunkt:
100°C
storage temp. 
2-8°C
Löslichkeit
DMSO: >20 mg/mL
Aggregatzustand
solid
Farbe
white
Merck 
14,1295
InChIKey
RZPZLFIUFMNCLY-WLHGVMLRSA-N
CAS Datenbank
104344-23-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 22
WGK Germany  3
RTECS-Nr. UB8390000
HazardClass  IRRITANT
HS Code  2922190900
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.

Bisoprolol fumarate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

Beschreibung

Bisoprolol fumarate is a β1-selective adrenergic blocker useful in the treatment of essential hypertension.

Chemische Eigenschaften

White Solid

Originator

E. Merck (W. Germany)

Verwenden

antiinflammatory

Verwenden

A selective β-adrenergic blocker. Used as an antihypertensive.

Verwenden

semi-synthetic kanamycin-derived aminoglycoside antibiotic

Verwenden

Labeled Bisoprolol, intended for use as an internal standard for the quantification of Bisoprolol by GC- or LC-mass spectrometry.

Verwenden

A selective a-adrenergic blocker. Used as an antihypertensive

Verwenden

A selective α-adrenergic blocker. Used as an antihypertensive.

Manufacturing Process

A solution of 10 g of 1-(p-2-isopropoxyethoxymethylphenoxy)-3-isopropylideneamino-propan-2-ol [obtainable by reacting 1-(p-2- isopropoxyethoxymethylphenoxy)-2,3-epoxy propane with ammonia to give 1- (p-2-isopropoxyethoxymethylphenoxy)-3-amino-propan-2-ol and subsequently reacting this with acetone] in 250 ml of ethanol was hydrogenated on 0.5 g of Raney nickel at 25°C under 1 atmosphere of pressure until 1 equivalent of H2 had been absorbed. The mixture was filtered and the filtrate evaporated to give 1-(p-2-iso-propoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol, fumarate, m.p. 100°C (after addition of equimolecular quantity of fumaric acid).

Trademarks

Zebeta (Duramed);CONCOR.

Therapeutic Function

Beta-adrenergic blocker

Biologische Aktivität

A selective β 1 -adrenergic antagonist. Has a K d of 2-3 nM at the β 1 receptor and a β 1 / β 2 selectivity of approximately 100-fold.

Biochem/physiol Actions

Bisoprolol hemifumarate is useful in oral formulations due to its high bioavailability. It also shows long elimination half-life.

Bisoprolol fumarate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bisoprolol fumarate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 357)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Chengdu Aslee Biopharmaceuticals, Inc.
+86 28 85305008
may.yang@asleechem.com CHINA 964 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 200 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 494 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

104344-23-2()Verwandte Suche:


  • (+-)-1-(p-((2-isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanolh
  • (+-)-mino)(e)-2-butenedioate(2:1)(salt)
  • 2-propanol,1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)a
  • 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt
  • NegativeioncolophonyPolymer
  • 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]propan-2-ol hemifumarate
  • Azopsin
  • Bisotate
  • Seafuri
  • Well-bi
  • (±)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate
  • 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1)
  • Bisoprolol Fumarate (200 mg)
  • Bisoprolol FuMarate, USP
  • 1-(propan-2-ylaMino)-3-(4-{[2-(propan-2-yloxy)ethoxy]Methyl}phenoxy)propan-2-ol
  • 1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol fuMarate
  • eMifuMarate bisoprolol fuMarate bisoprololheMifuMarate
  • (2RS) -1-{4-[(2-isopropoxyethoxy)Methyl]phenoxy}-3-(isopropylaMino)propan-2-ol fuMarate
  • Bisoprolol f
  • 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol,(2E)-2-butenedioate (2:1)
  • Bisoprolol fumarate
  • (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanolhemifumarate
  • Bisoprolol for system suitability
  • Bisoprolol for peak identification
  • emd33512
  • emifumarate
  • MONOCOR
  • SOPROL
  • ZEBETA
  • ISOTEN
  • (+/-)-BISOPROLOL HEMIFUMARATE
  • 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol fumarate salt
  • BISOPROLOL HEMIFUMARATE
  • EURADIAL
  • DETENSIEL
  • EMCOR
  • CONCOR
  • 1-[4-[[2-(1-METHYLETHOXY)ETHOXY]METHYL]PHENOXY]-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL
  • (+/-)-1-[4-[[(2-(1-METHYLETHOXY)ETHOXY)METHYL]PHENOXY]-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL] HEMIFUMARATE
  • 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, Concor, Detensiel, Emcor, Euradial, Isoten, Monocor, Soprol, Zebeta,
  • 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (+-)-, (E)-2-butenedioate (2:1) (salt) (8CI)
  • 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt)
  • 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt)
  • Emvoncor
  • Eurtadal
  • Bisoprololfumarat
  • Bisoprolol for peak identification CRS
  • Bisoprolol for system suitability CRS
  • Bisoprolol fumarate CRS
  • Bisoprolol fumarate fandachem
  • EMD33512 fandachem
  • Bisoprololhemifumaratesalt,98%
  • Bisoprolol fumarate USP/EP/BP
  • 104344-23-2
  • C18H31NO42C4H4O4
  • C18H31NO4sup1sup2C4H4O4
  • C40H66N2O12
  • C22H35NO8
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