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Doxercalciferol Produkt Beschreibung

Doxercalciferol Struktur
54573-75-0
CAS-Nr.
54573-75-0
Englisch Name:
Doxercalciferol
Synonyma:
C08211;TSA 840;1α-OHD2;Hectorol;ERCALCIDOL;1ALPHA-OH-D2;Doxecalciferol;Doxercalcifero;Doxercalciferol;Doxercalciferol d6
CBNumber:
CB8394169
Summenformel:
C28H44O2
Molgewicht:
412.65
MOL-Datei:
54573-75-0.mol

Doxercalciferol Eigenschaften

Schmelzpunkt:
138-140°C
storage temp. 
Desiccate at -20°C
Löslichkeit
DMSO: >10mg/mL
Aggregatzustand
White crystalline solid
CAS Datenbank
54573-75-0(CAS DataBase Reference)
EPA chemische Informationen
9,10-Secoergosta- 5,7,10(19),22-tetraene-1, 3-diol, (1.alpha.,3.beta.,5Z,7E,22E)- (54573-75-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+
R-Sätze: 28
S-Sätze: 28-36/37-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS-Nr. VS2950000
HS Code  2936299055
Toxizität LD50 orally in rats: 3.5-6.5 mg/kg (Sjden)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Doxercalciferol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.

Chemische Eigenschaften

Doxercalciferol is Crystalline Solid

Originator

Bone Care Int. (US)

Verwenden

Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma. Antihyperparathyroid

Trademarks

Hectorol (Genzyme).

Biologische Aktivität

Vitamin D 2 analog that acts as a vitamin D receptor activator (VDRA).

Doxercalciferol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Doxercalciferol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 108)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21726 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2289 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23976 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

54573-75-0()Verwandte Suche:


  • 7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5
  • VITAMIN D2, 1ALPHA-HYDROXY-
  • Vitamin D2, 1a-Hydroxy-
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • Doxercalciferol
  • 1A, 25-DIHYDROXYERGOCALCIFEROL
  • 1A-HYDROXYERGOCALCIFEROL (NON GMP)
  • ERCALCIDOL
  • Doxecalciferol
  • 4-Methylene-5-{2-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidene]-ethylidene}-cyclohexane-1,3-diol (1-alpha-Hydroxyvitamin D2)
  • (1a,3,5Z,7E,22E)- 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol1-Hydroxyergocalciferol
  • 1a-Hydroxyergocalciferol
  • 1a-Hydroxyvitamin D2
  • 1-Hydroxy Vitamin D2
  • 1-Hydroxyvitamin D2
  • Hectorol
  • TSA 840
  • C08211
  • 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
  • (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • (1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyl-octahydroinden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1?,3?-diol
  • (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
  • 1α-OHD2
  • (1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
  • Vitamin D, 1α-Hydroxy- - CAS 54573-75-0 - Calbiochem
  • 1ALPHA-OH-D2
  • 1-alpha-hydroxyergocalciferol
  • 1alpha-hydroxyergocalciferol
  • 1-alpha-hydroxyvitamind2
  • 1-hydroxyergocalciferol
  • 1-alpha-Hydroxy Vitamin D2-d6
  • Doxercalciferol d6
  • (1S,3R,5Z,7E,22E)-9,10-Seco
  • 4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol
  • (1R,3S,E)-5-((E)-2-((1R,3AS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1H-
  • Doxercalciferol / Ercalcidol
  • Doxercalcifero
  • Doxercalciferol CAS NO.54573-75-0 CAS NO.54573-75-0
  • (5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
  • 54573-75-0
  • C28H44O2
  • Vitamin D3 analogs
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • -
  • Inhibitors
  • TCI-
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