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Calcitrol Produkt Beschreibung

Calcitriol Struktur
32222-06-3
CAS-Nr.
32222-06-3
Bezeichnung:
Calcitrol
Englisch Name:
Calcitriol
Synonyma:
Silkis;ro215535;Panbonis;Calcijex;Soltriol;Toptriol;rocaltrol;Rocalirol;Solbone P;Calcitrio
CBNumber:
CB0171027
Summenformel:
C27H44O3
Molgewicht:
416.64
MOL-Datei:
32222-06-3.mol

Calcitrol Eigenschaften

Schmelzpunkt:
119-1210C
alpha 
D25 +48° (methanol)
Siedepunkt:
474.91°C (rough estimate)
Dichte
1.0362 (rough estimate)
Brechungsindex
1.4700 (estimate)
Flammpunkt:
14 °C
storage temp. 
2-8°C
Löslichkeit
Do you have solubility information on this product that you would like to share
pka
14.43±0.40(Predicted)
Aggregatzustand
Solid
maximale Wellenlänge (λmax)
265nm(lit.)
Merck 
14,1644
BRN 
7559394
Stabilität:
Air and Light Sensitive
InChIKey
GMRQFYUYWCNGIN-UNVJKIGWSA-N
CAS Datenbank
32222-06-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,Xn,F
R-Sätze: 26/27/28-63-36/37/38-20/21/22-11
S-Sätze: 36/37/39-45-36-26-16-7
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS-Nr. FZ4645000
8-10-19
HazardClass  6.1(a)
PackingGroup  I
HS Code  29061900
Giftige Stoffe Daten 32222-06-3(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P370+P378 Bei Brand: zum Löschen verwenden.
P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.

Calcitrol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemische Eigenschaften

White Crystalline Powder

Originator

Rocaltrol,Roche,US,1978

Verwenden

Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

Verwenden

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

Verwenden

Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]

Verwenden

Calcium regulator, anti-psoriatic

Definition

ChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.

Manufacturing Process

1α,25-Dihydroxyprecholecalciferol: A solution of 1α,25- diacetoxyprecholecalciferol (0.712 g, 1.42 mmols), potassium hydroxide (2.0 g, 35.6 mmols) and methanol (40 ml) was stirred at room temperature under argon for 30 hours. The reaction mixture was concentrated under reduced pressure. Water (50 ml) was added to the residue and the mixture was extracted with methylene chloride (3 x 100 ml). The combined organic extracts were washed with saturated sodium chloride solution (3 x 50 ml), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give 0.619 g of 1alpha,25-dihydroxyprecholecalciferol as a thick oil.
1α,25-Dihydroxycholecalciferol: A solution of 1α,25-dihydroxyprecholecalciferol [0.619 g in dioxane (30 ml)] was heated under reflux for 30 minutes under an atmosphere of argon. The reaction mixture was concentrated under reduced pressure and the residue was purified with a Waters Associates liquid chromatograph model 202 using a 8 foot * 3/8 inch Porasil A column and a 5:1 mixture of ethyl acetate-n-hexane as the eluent to give 0.474 g (80% yield based on 1α,25-diacetoxyprecholecalciferol) of pure 1α,25- dihydroxycholecalciferol. Recrystallization from methyl formate afforded 0.340 g of 1α,25-dihydroxcholecalciferol as colorless crystals, MP 113°-114°C.

Trademarks

Calcijex (Abbott); Rocaltrol (Roche.

Therapeutic Function

Calcium regulator

Biologische Aktivität

Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Veterinary Drugs and Treatments

Calcitriol may be potentially beneficial in the adjunctive treatment of chronic renal disease in dogs and cats but its use is somewhat controversial, particularly the decision on how soon in the course of chronic renal insufficiency it should employed. It may also be of benefit in treating some types of dermatopathies (primary idiopathic seborrhea).

Calcitrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Calcitrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 362)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
18691773435
086-029-84536389 sales@yutbon.com CHINA 304 58
Honest Joy Holdings Limited
13717124449 0755-36694831
0755-33586111 sale@feiyang.com.cn CHINA 298 58
Finetech Industry Limited
86 27 87465837
86 27 87772287 info@finetechnology-ind.com CHINA 9371 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21535 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22608 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8875 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3066 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55

32222-06-3(Calcitrol)Verwandte Suche:


  • VITAMIN D3, 1ALPHA,25-DIHYDROXY
  • (5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
  • 9,10-SECOCHOLESTA-5Z,7E,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL
  • 1,25-(OH)2-D3
  • (1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
  • 1ALPHA,25-DIHYDROXYCHOLECALCIFEROL
  • 1ALPHA,25-DIHYDROXYVITAMIN D3
  • 1ALPHA,25-DIHYDROXY-VITAMIN D8
  • 1A, 25-DIHYDROXYCHOLECALCIFEROL
  • CALCITRIOL
  • (5z,7e)-9,10-secochesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol
  • 7,10(19)-triene-1,3,25-triol,(1-alpha,3-beta,5z,7e)-10-secocholesta-5
  • 7,10(19)-triene-1,3,25-triol,(1alpha,3beta,5z,7e)-10-secocholesta-5
  • 9,10seco(5z,7e)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol
  • dihydroxyvitamind3
  • ro215535
  • rocaltrol
  • 1A25-dihydroxycholecalciferol(+4℃)
  • Rocalirol
  • (1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-Methylheptan-2-yl]-7a-Methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-Methylidenecyclohexane-1,3-diol
  • Calcitriol (Rocaltrol)
  • (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-diMethylhexyl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • Panbonis
  • Solbone P
  • 1a,25-Dihydroxyvitamin
  • 1α,25-Dihydroxyvitamin D3,1α,25-Dihydroxycholecalciferol, Calcitriol
  • Calcitriol (10 mg)F0E0620.993mg/mg(ai)
  • Calcitriol (10 mg) (COLD SHIPMENT REQUIRED)
  • 1,25-Dihydroxyvitamin-D3-[2H3]
  • Calcitrio
  • 1,25- DIHYDROXYVITAMIN D3 (6,19,19-D3) Solution
  • 1,25- DIHYDROXYVITAMIN D3 (6,19,19-D3) Calcitriol-D3
  • (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-octahydroinden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • aslpha,25-Dihydroxycholecalciferol
  • 1α,25-Dihydroxyvitamin D3 solution
  • (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol monohydrate
  • 1α,25-Dihydroxycholecalciferol monohydrate
  • 1α,25-Dihydroxyvitamin D3 monohydrate
  • 1α,25-Dihydroxycalciferol solution
  • 1,25-DihydroxyvitaMin D3 Calcitriol
  • Vitamin D3, 1a,25-Dihydroxy-
  • CALCITRIOL USP
  • 1α,25-Dihydroxyvitamin D3
  • (1a,3b,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol,
  • Calcijex
  • Silkis
  • Soltriol
  • Topitriol
  • Toptriol
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1.alpha.,3.beta.,5Z,7E)-
  • (5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol
  • 1,25-dhcc
  • 1,25-dihydroxycholecalciferol
  • 1,25-dihydroxyvitamind
  • 1a,25-dihydroxy-cholecalcifero
  • 1-alpha,25-dihydroxy-cholecalcifero
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1α,3β,5Z,7E)-
  • 1,25-DIHYROXYCHOLECALIFEROL
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