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Propylamin Produkt Beschreibung

CAS-Nr.107-10-8
Bezeichnung:Propylamin
Englisch Name:Propylamine
Synonyma:
PA;MNPA;AMINE C3;n-C3H7NH2;Propylamin;Propanamine;PROPYLAMINE;PROPANEAMINE;1-Propylamine;1-Aminopropan
CBNumber:CB8401908
Summenformel:C3H9N
Molgewicht:59.11
MOL-Datei:107-10-8.mol
Propylamin physikalisch-chemischer Eigenschaften
Schmelzpunkt:: -83 °C
Siedepunkt:: 48 °C(lit.)
Dichte: 0.719 g/mL at 25 °C(lit.)
Dampfdichte: 2 (vs air)
Dampfdruck: 4.79 psi ( 20 °C)
Brechungsindex: n20/D 1.388(lit.)
FEMA : 4237 | PROPYLAMINE
Flammpunkt:: −35 °F
storage temp. : 0-6°C
Löslichkeit: water: soluble0.4 part(lit.)
pka: 10.6(at 20℃)
Aggregatzustand: Liquid
Farbe: Clear colorless to pale yellow
Wichte: 0.7173
PH: 12.6 (100g/l, H2O, 20℃)
Explosionsgrenze: 2.1-13.6%(V)
Wasserlöslichkeit: soluble
Sensitive : Air Sensitive
Merck : 14,7843
JECFA Number: 1580
BRN : 1098243
Expositionsgrenzwerte: No exposure limit has been set. Based on its similarity to ethylamine in irritation and toxicity, a TLV-TWA of 10 ppm (~24 mg/m3) should be appropriate. .
Stabilität:: Stable. Highly flammable. Note low flash point. Readily forms explosive mixtures with air. Incompatible with oxidising agents, strong acids. Store cool.
CAS Datenbank: 107-10-8(CAS DataBase Reference)
NIST chemische Informationen: 1-Propanamine(107-10-8)
EPA chemische Informationen: 1-Propanamine(107-10-8)
Sicherheit
Kennzeichnung gefährlicher: F,C
R-Sätze:: 11-20/21/22-34-35-52/53
S-Sätze:: 26-36/37/39-45-16-7/9-36-61
RIDADR : UN 1277 3/PG 2
WGK Germany : 1
RTECS-Nr.: UH9100000
F : 34
Selbstentzündungstemperatur: 604 °F
TSCA : Yes
HS Code : 2921 19 99
HazardClass : 3
PackingGroup : II
Giftige Stoffe Daten: 107-10-8(Hazardous Substances Data)
Toxizität: LD50 orally in rats: 0.57 g/kg (Smyth)

Propylamin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE, HYGROSKOPISCHE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche (Stickstoffoxide). Mittelstarke Base, reagiert mit Säuren und greift Aluminium und Zink an. Reagiert sehr heftig mit Oxidationsmitteln und Quecksilberunter Feuer- und Explosionsgefahr. Reagiert sehr heftig mit vielen Verbindungen wie halogenierte Kohlenwasserstoffe, Alkohole und einige Nitroparaffine. Greift Kupfer und Kupferlegierungen an.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz verätzt die Augen, die Haut und die Atemwege.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Zündquellen entfernen. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Verschüttete Flüssigkeit mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
colourless liquid with a strong odour of ammonia
Chemische Eigenschaften
n-Propylamine is a water-white liquid with a strong irritating odor similar to that of ammonia
Chemische Eigenschaften
Propylamine is very basic, therefore it tends to readily form salts with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961).
Chemische Eigenschaften
Colorless to yellow liquid; aggressive ammonia aroma.
Verwenden
n-Propylamine is used as an intermediate inmany organic reactions.
Verwenden
Intermediate, lab reagent.
Vorbereitung Methode
There are several methods employed in the manufacture of propylamine. Typically, ammonia and propanol are reacted over a dehydration catalyst at high temperature and pressure. Ammonia, propanol, and hydrogen can also be reacted over a dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer et al 1978).
Aroma threshold values
High strength odor; ammoniacal type; recommend smelling in a 0.10% solution or less.
Allgemeine Beschreibung
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.
Air & Water Reaktionen
Highly flammable. Slightly soluble in water.
Reaktivität anzeigen
Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Propylamine emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].
Hazard
Highly flammable, dangerous fire risk, explosive limits in air 2–10%, use alcohol foam to extinguish. Strong irritant to skin and tissue.
Health Hazard
INHALATION: Mucous membrane and respiratory tract irritation. Tracheitis, bronchitis, pneumonitis, and pulmonary edema. EYES: Severe corneal damage or complete eye destruction. SKIN: Single drop-deep necrosis. INGESTION: Corrosive to G.I. tract.
Health Hazard
Direct contact of n-propylamine liquid can result in skin burns or severe eye damage (RTECS 1988). Inhalation of vapors may injure the eyes and respiratory tract. No permissible exposure levels (PEL) or levels immediately dangerous to life or health (IDLH) for n-propylamine have been established.
Health Hazard
n-Propylamine is a strong irritant and a mod erately toxic substance. the toxic routes areinhalation, ingestion, and absorption throughthe skin. Contact of the liquid on the skincan cause burns and possibly skin sensitization. Irritation in the eyes from exposure tohigh concentrations can be severe. It is a respiratory tract irritant, similar to ethylamine.Inhalation of 2300 ppm of n-propylamine for4 hours caused labored breathing, hepatitis,and hepatocellular necrosis in rats. It is somewhat less toxic than ethylamine by oral anddermal routes.
LC50 value, inhalation (mice): 2500 mg/m3/2 hr

LD50 value, oral (rats): 570 mg/kg
LD50 value, skin (rabbits): 560 mg/kg.
Brandgefahr
Highly flammable liquid; flash point (closed cup) -37°C (-35°F); vapor density 2.0 (air = 1), vapor can travel a considerable distance to a source of ignition and flash back; autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or “alcohol” foam; water should be used to keep fire-exposed containers cool and to flush and dilute the spill.
n-Propylamine forms explosive mixtures in air; LEL and UEL values are 2.0% and 10.4% by volume in air, respectively. There is no report of explosion associated with this compound. It is expected to exhibit violent reactions characteristic of lower aliphatic primary amines .
Industrielle Verwendung
Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs, propyl isocyanate, textile and leather finishing resins and corrosion inhibitors. It is also used in the production of pharmaceuticals such as Prilocaine, pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of propylamine were manufactured in the U.S. (HSDB 1988).
Sicherheitsprofil
Moderately toxic by inhalation, ingestion, and skin contact routes. A skin and severe eye irritant. Possibly a skin sensitizer. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. Incompatible with triethynyl aluminum. See also AMINES.
mögliche Exposition
Propylamine is used to make textile resins, drugs, pesticides, and other chemicals.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24?48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Stoffwechsel
To date, there are several studies which indicate that propylamine may be metabolized in many animal species, including man. When propylamine hydrochloride was administered to humans orally, little of the parent compound was recovered in the urine (Rechenberger 1940). It has also been reported that dogs are capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966) demonstrated that monoamine oxidase, purified from rabbit serum, was capable of oxidizing propylamine, although less actively than substituted phenylethylamines such as dopamine. Further characterization revealed that the protonated amine is bound by an unprotonated enzyme group, that the enzyme active site is composed of hydrophobic residues, and that interaction of the amine residues determines maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of the amine could be stimulated by the presence of aliphatic alcohols which apparently bond in a tertiary complex with the enzyme and substrate, thereby increasing the effectiveness of substrate binding.
Other investigators have provided evidence that propylamine may not be a substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974). Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not metabolize propylamine.
Versand/Shipping
UN1277 Propylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.
läuterung methode
Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.]
Inkompatibilitäten
Vapors may form explosive mixture with air. Violent reaction on contact with oxidizers and mercury, strong acids; organic anhydrides; isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons; alcohols and many other compounds. Attacks many metals and alloys, especially those of copper. Aqueous solution is acidic and may attack glass.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Propylamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Di-n-Propylamin Propionaldehyd 2-Nitropropan Tri-n-propylamin Acrylnitril Aluminiumoxid Propan-1-ol
Downstream Produkte
Di-n-Propylamin Tri-n-propylamin N-[2-(2,4,6-Trichlorphenoxy)ethyl]propylamin Prilocain
Propylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 215)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Mainchem Co., Ltd.
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Xiamen AmoyChem Co., Ltd
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career henan chemical co
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Chemwill Asia Co.,Ltd.
86-21-51086038
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Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
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Haihang Industry Co.,Ltd
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+86 531 8582 1093export@haihangchem.com CHINA 4660 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
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Alfa Aesar 400-610-6006; 021-67582000
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TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385Sales-CN@TCIchemicals.com China 24560 81
 
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