eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC
50 ~15 μM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (
Cat. No. 654380). Prevents HSV replication both in Vero cells (IC
50 ~3 μM for reducing plaque formation) in vitro and in a mouse cornea infection model
in vivo. The solid form of this compound (Cat. No.
324895) is also available.
Biochem/physiol Actions
Cell permeable: yes
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte