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Propylencarbonat Produkt Beschreibung

Propylene carbonate  Struktur
108-32-7
CAS-Nr.
108-32-7
Bezeichnung:
Propylencarbonat
Englisch Name:
Propylene carbonate
Synonyma:
PC;1,2-PDC;ARCONATE;texacarpc;Texacar PC;Solvenon PC;arconate5000;1.2-Propylene;ene carbonate;ARCONATE(R) PC
CBNumber:
CB8852744
Summenformel:
C4H6O3
Molgewicht:
102.09
MOL-Datei:
108-32-7.mol

Propylencarbonat Eigenschaften

Schmelzpunkt:
-55 °C (lit.)
Siedepunkt:
240 °C (lit.)
Dichte
1.204 g/mL at 25 °C (lit.)
Dampfdruck
0.13 mm Hg ( 20 °C)
Brechungsindex
n20/D 1.421(lit.)
Flammpunkt:
270 °F
storage temp. 
Store below +30°C.
Löslichkeit
240g/l
Aggregatzustand
Liquid
Farbe
Clear
Wichte
1.209 (20/4℃)
PH
7.0 (200g/l, H2O, 20℃)
Relative polarity
6
Explosionsgrenze
1.8-14.3%(V)
Wasserlöslichkeit
240 g/L (20 ºC)
maximale Wellenlänge (λmax)
λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
BRN 
107913
Stabilität:
Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.
InChIKey
RUOJZAUFBMNUDX-UHFFFAOYSA-N
CAS Datenbank
108-32-7(CAS DataBase Reference)
NIST chemische Informationen
Propylene carbonate(108-32-7)
EPA chemische Informationen
Propylene carbonate (108-32-7)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36
S-Sätze: 26-37/39
WGK Germany  1
RTECS-Nr. FF9650000
3-10
Selbstentzündungstemperatur 851 °F
TSCA  Yes
HS Code  29209010
Giftige Stoffe Daten 108-32-7(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Propylencarbonat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36:Reizt die Augen.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Propylene carbonate is a clear, colorless, mobile liquid, with a faint odor.

Chemische Eigenschaften

colourless liquid

Verwenden

Pharmaceutic aid (gelling agent).

Verwenden

propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent.

Vorbereitung Methode

Propylene carbonate may be prepared by the reaction of sodium bicarbonate with propylene chlorohydrin.

synthetische

To a stirred solution of 1,2- propanediol 957 (230 mg, 3.0 mmol) in toluene (8 mL) was added DPC (670 mg, 3.1 mmol). After stirring at 110 ℃ for 1.5 h, the reaction mixture was allowed to cool to room temperature, diluted with dichloromethane (40 mL), washed with brine (30 mL), dried over anhydrous MgSO4, and concentrated to dryness under reduced pressure. The crude product was distilled in vacuo in a kugelrohr apparatus to give 4-methyl-1,3-dioxolan-2-one 958 (254 mg) in 83% yield.

Pharmazeutische Anwendungen

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations.
In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations.
Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

Sicherheit(Safety)

Propylene carbonate is used as a solvent in oral and topical pharmaceutical formulations, and is generally regarded as an essentially nontoxic and nonirritant material.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg

Lager

Propylene carbonate and its aqueous solutions are stable but may degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.

läuterung methode

It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]

Inkompatibilitäten

Propylene carbonate hydrolyzes rapidly in the presence of strong acids and bases, forming mainly propylene oxide and carbon dioxide. Propylene carbonate can also react with primary and secondary amines to yield carbamates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Propylencarbonat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Propylencarbonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 405)Lieferanten
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Dayang Chem (Hangzhou) Co.,Ltd.
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Jinan Finer Chemical Co., Ltd
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108-32-7(Propylencarbonat)Verwandte Suche:


  • 1,2-propanediolcarbonate
  • 1,2-Propanediyl carbonate
  • 1,2-propanediylcarbonate
  • 1,3-Dioxolan-2-one, 4-methyl-
  • 1,3-dioxolane-2-one,4-methyl
  • 1-Methylethylene carbonate
  • 1-methylethylenecarbonate
  • 2-Propanediolcycliccarbonate
  • 3-Dioxolan-2-one,4-methyl-1
  • 4-methyl-1,3-dioxolan-z-one
  • 4-Methyl-2-oxo-1,3-dioxolane
  • 4-methyl-3-dioxolan-2-one
  • 4-Methyldioxalone-2
  • Arconate propylene carbonate
  • arconate5000
  • carbonatedepropylene
  • carbonicacid,cyclicpropyleneether
  • carbonicacid,propyleneester
  • carbonicacidcyclicmethylethyleneester
  • Cyclic 1,2-propylene carbonate
  • Cyclic methylethylene carbonate
  • Cyclic propylene carbonate
  • cyclic1,2-propylenecarbonate
  • cyclicmethylethylenecarbonate
  • cyclicpropylenecarbonate
  • Dipropylene carbonate
  • dipropylenecarbonate
  • Propylene glycol cyclic carbonate
  • propyleneglycolcycliccarbonate
  • Propylenester kyseliny uhlicite
  • PC
  • PROPANEDIOL CYCLIC CARBONATE
  • PROPYLENE CARBONATE
  • PROPYLENE CARBONATE S
  • PROPYLENE GLYCOL CARBONATE
  • propylene carbonate B&J brand 1 L
  • Propylene carhonate
  • PROPYLENE CARBONATE, ANHYDROUS
  • PROPYLENE CARBONATE, REAGENTPLUS, 99%
  • PROPYLENE CARBONATE, ANHYDROUS, 99.7%
  • PROPYLENE CARBONATE 99+%
  • PROPYLENE CARBONATE, 99.7%, HPLC GRADE
  • PROPYLENE CARBONATE 'B&J BRAND'
  • Propylene Carbonate, High Purity
  • PROPYLENE CARBONATE GC STANDARD
  • PropyleneCarbonate(Pc)
  • PROPYLENE CARBONATE PESTANAL
  • Propylene carbonate, 99.50%
  • PROPYLENECARBONATE,REAGENT
  • Propylencarbonat
  • 1,2-Propanediol cyclic carbonate, 4-Methyl-1,3-dioxolan-2-one
  • Carbonic acid propylene
  • Propylene carbonate,99.5%
  • 2-Oxo-4-methyl-1, 3-dioxolan
  • PROPYLENE CARBONATE pure
  • Diester of 2-carboxymethoxy thioxanthone and Poly tetra- methyleneglycol 250
  • Propylene carbonate,1,2-Propanediol cyclic carbonate, 4-Methyl-1,3-dioxolan-2-one
  • Propylene carbonate, 99%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal
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