Propionitril Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe mischen sich leicht mit Luft. Bildung explosionsfähiger Gemische.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden und Cyanwasserstoff. Reagiert sehr heftig mit starken Oxidationsmitteln. Feuer- und Explosionsgefahr. Reagiert mit Säuren, Wasserdampf und warmem Wasser unter Freisetzung giftigen und entzündlichen Cyanwasserstoffs.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Möglich sind Auswirkungen auf den Eisenstoffwechsel mit nachfolgender Erstickung. Exposition kann zu Bewusstlosigkeit, Herzrhythmusstörungen und Tod führen. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Belüftung. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R20:Gesundheitsschädlich beim Einatmen.
R25:Giftig beim Verschlucken.
R27:Sehr giftig bei Berührung mit der Haut.
R36:Reizt die Augen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Chemische Eigenschaften
Propionitrile is a colorless liquid with a pleasant, sweetish, ethereal odor. Propionitrile [107-12-0], ethyl cyanide, CH3CH2CN, is a colorless liquid which is miscible with water, ethanol, dimethylformamide, and diethyl ether. The physical properties are listed in Table 1. Propionitrile is obtained either by hydrogenation of acrylonitrile or by the gas-phase reaction of propanal or propanol with ammonia. It is also obtained as a byproduct in the electrohydrodimerization of acrylonitrile to adiponitrile (EHD process).
Verwenden
Propionitrile is an intermediate for organic syntheses, e.g. Houben-Hoesch reaction, as well as for pharmaceuticals, e.g. ketoprofen and fragrances.
Vorbereitung Methode
Propionitnle may be prepared by dehydration of propionamide (or propionic acid
plus ammonia) or by distilling ethyl sulfate and concentrated aqueous KCN. It also is formed as a byproduct of the electrohydrodimerization
of acrylonitrile or by the hydrogenation of acrylonitrile with the use of
copper, rhodium or nickle catalysts . U.S. production
is estimated for 1980 to range between 10-15 million pounds.
Definition
ChEBI: A nitrile that is acrylonitrile in which the carbon-carbon double bond has been reduced to a single bond.
Allgemeine Beschreibung
A colorless liquid with an ether-like odor. Density 0.683 g / cm3. Flash point 61°F. Toxic by inhalation, skin absorption, and ingestion. Vapors are heavier than air. Used as a solvent, and to make other chemicals.
Air & Water Reaktionen
Highly flammable. Soluble in water.
Reaktivität anzeigen
Propionitrile is incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. After refluxing for 24 hours at 221°F, a mixture of Propionitrile with N-bromosuccinimide exploded.
Hazard
Toxic by ingestion and inhalation.
Flammable, dangerous fire risk.
Health Hazard
Propionitrile is highly toxic. This super toxic compound has a probable oral lethal dose in humans of less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. It is a mild to moderate skin and eye irritant.
Brandgefahr
When heated to decomposition, Propionitrile emits toxic fumes of nitrogen oxides and cyanide. Propionitrile is a flammable/combustible material and may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Generates cyanide ions. Poisonous on contact with acids. stable, but may become unstable at elevated temperatures and pressures.
Industrielle Verwendung
Propionitnle is used as a selective solvent in the chemical industry and in
petroleum refining and as a dielectric fluid . It
has also been used experimentally as an ulcerogen .
Sicherheitsprofil
Poison by ingestion,
skin contact, intravenous, and
intraperitoneal routes. Moderately toxic by
inhalation. Experimental teratogenic effects.
Other experimental reproductive effects. A
skin and eye irritant. Dangerous fire hazard
when exposed to heat, flame (sparks),
oxidners. Mixture with N-
bromosuccinimide may explode when heated. To fight fire, use water spray, foam,
mist, CO2, dry chemical. When heated to
decomposition it emits toxic fumes of NOx
and CN-. Used as a solvent in petroleum
refining, and as a raw material for drug
manufacture. See also NITRILES.
mögliche Exposition
Used as a solvent in petroleum refin-
ing, as a chemical intermediate; a raw material for drug
manufacture; and a setting agent.
Versand/Shipping
UN2404 Propionitrile, Hazard Class: 3; Labels:
3-Flammable liquid, 6.1-Poisonous material.
UN1992 Flammable liquids, toxic, n.o.s., Hazard Class: 3;
Labels: 3-Flammable liquid, 6.1-Poisonous materials,
Technical Name Required.
läuterung methode
Shake the nitrile with dilute HCl (20%), or with conc HCl until the odour of isonitrile has gone, then wash it with water, and aqueous K2CO3. After a preliminary drying with silica gel or Linde type 4A molecular sieves, it is stirred with CaH2 until hydrogen evolution ceases, then decant and distil from P2O5 (not more than 5g/L, to minimise gel formation). Finally, it is refluxed with, and slowly distilled from CaH2 (5g/L), taking precautions to exclude moisture. [Beilstein 2 IV 728.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlo-
rine, bromine, fluorine, etc.); contact may cause fires or
explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, epoxides., reducing agents.
Hydrogen cyanide is produced when propionitrile is
heated to decomposition. Reacts with acids, steam, warm
water; producing toxic and flammable hydrogen cyanide
fumes. Nitriles may polymerize in the presence of
metals and some metal compounds. They are incompati-
ble with acids; mixing nitriles with strong oxidizing
acids can lead to extremely violent reactions. Nitriles
are generally incompatible with other oxidizing agents
such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide.
Nitriles are hydrolyzed in both aqueous acid and base
to give carboxylic acids (or salts of carboxylic acids).
These reactions generate heat. Peroxides convert
nitriles to amides. Nitriles can react vigorously with
reducing agents. Acetonitrile and propionitrile are
soluble in water, but nitriles higher than propionitrile
have low aqueous solubility. They are also insoluble
in aqueous acids .
Waste disposal
Alcoholic NaOH followed by
calcium hypochlorite may be used, as may incineration .
Consult with environmental regulatory agencies for guid-
ance on acceptable disposal practices. Generators of waste
containing this contaminant (≥100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal.
Propionitril Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
