Chlorthenoxazin

chlorthenoxazine  Struktur
132-89-8
CAS-Nr.
132-89-8
Bezeichnung:
Chlorthenoxazin
Englisch Name:
chlorthenoxazine
Synonyma:
Ap 67;Valtorin;Valmorin;Piroxina;Ossazone;Apirazin;chlorthenoxazin;chlorthenoxazine;Chlorethylbenzmethoxazone;Chlorthenoxazine,inhibit,Inhibitor
CBNumber:
CB9899858
Summenformel:
C12H8ClNO
Molgewicht:
217.65102
MOL-Datei:
132-89-8.mol

Chlorthenoxazin Eigenschaften

Schmelzpunkt:
146-147° (dec)
Siedepunkt:
303°C (rough estimate)
Dichte
1.2414 (rough estimate)
Brechungsindex
1.5500 (estimate)
storage temp. 
Store at -20°C
Löslichkeit
Soluble in DMSO
pka
12.70±0.40(Predicted)

Sicherheit

Chlorthenoxazin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Reugaril ,Farber ,Italy ,1966

Manufacturing Process

A mixture of 4 liters chloroform and 1,050 cc ethanol was saturated with dry hydrogen chloride gas at -5°C to +5°C in a vessel having a net volume of 15 liters and provided with a stirring device, reflux cooler, gas feed line, thermometer and dropping funnel. 455 g acrolein which had been precooled to 0°C were added dropwise to the solution over a period of 1 to 2 hours while maintaining the temperature below +5°C and vigorously stirring. 1,070 g salicylamide and 1,080 g glacial acetic acid were added to the resulting solution of beta-chloropropionaldehyde acetal, thereby forming a suspension which was heated to 60°C while stirring. A clear solution was formed which was maintained at 60°C for an additional hour. The solution was allowed to cool to about 40°C and was then washed with water by passing a strong stream of water under the surface of the chloroform and continuously withdrawing the upper phase. When the water had reached a pH of 3-4, the precipitated reaction product was separated by vacuum filtration. The chloroform phase of the filtrate was evaporated under a weak vacuum and the residue was combined with the precipitate first obtained. The combined products were stirred with 2 liters of a 5% sodium hydroxide solution. The raw reaction product was then washed with water, dried and recrystallized from ethanol. The product had the melting point of 146°C to 147°C (decomposition). The yield was 1,260 g, corresponding to 76% of the theoretical yield.

Therapeutic Function

Antipyretic, Analgesic

Chlorthenoxazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlorthenoxazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 14)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30255 58
Aikon International Limited 025-66113011 18112977050
cb6@aikonchem.com China 15495 58
Suzhou Rovathin Foreign Trade Co.,Ltd 0512-65816829 18662214788
info@rovathin.com.cn China 9335 58
Amel Pharmatech Corporation 888-4366503
sales@amelpharmatech.com China 5351 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613
sales@chemrenpharm.com China 3538 58
Shanghai Hecheng Medical Technology Co., LTD 13564747822
669027880@qq.com China 957 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8618 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223
psaitong@jm-bio.com China 29834 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 15229059051
1027@dideu.com China 9921 58

132-89-8(Chlorthenoxazin)Verwandte Suche:


  • chlorthenoxazine
  • chlorthenoxazin
  • Ap 67
  • Apirazin
  • Ossazone
  • Piroxina
  • Valmorin
  • Valtorin
  • 2-(2-chloroethyl)-2,3-dihydro-1,3-benzoxazin-4-one
  • 4H-1,3-Benzoxazin-4-one,2-(2-chloroethyl)-2,3-dihydro-
  • 2-(2-chloroethyl)-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one
  • Chlorethylbenzmethoxazone
  • Chlorthenoxazine,inhibit,Inhibitor
  • 132-89-8
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