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2-Hydroxybenzamid Produkt Beschreibung

Salicylamide Struktur
65-45-2
CAS-Nr.
65-45-2
Bezeichnung:
2-Hydroxybenzamid
Englisch Name:
Salicylamide
Synonyma:
OHB;Acket;Samid;Cidal;Salrin;sr4326;Anamid;h.p.34;Oramid;Algamon
CBNumber:
CB4854078
Summenformel:
C7H7NO2
Molgewicht:
137.14
MOL-Datei:
65-45-2.mol

2-Hydroxybenzamid Eigenschaften

Schmelzpunkt:
140-144 °C(lit.)
Siedepunkt:
270°C
Dichte
1,175 g/cm3
Brechungsindex
1.5323 (estimate)
Flammpunkt:
181°C/14mm
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
methanol: 0.1 g/mL, clear
pka
pKa 8.13(H2O t = 37) (Uncertain)
Aggregatzustand
Crystalline Powder
Farbe
White
Geruch (Odor)
Odorless
Säure-Base-Indikators(pH-Indikatoren)
5 (0.2% aq soln)
Wasserlöslichkeit
<0.1 g/100 mL at 20 ºC
Decomposition 
270°C
Merck 
14,8328
BRN 
742439
Stabilität:
Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-N
CAS Datenbank
65-45-2(CAS DataBase Reference)
NIST chemische Informationen
Benzamide, 2-hydroxy-(65-45-2)
EPA chemische Informationen
o-Hydroxybenzamide (65-45-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38-20/21/22
S-Sätze: 26-36
RIDADR  3249
WGK Germany  3
RTECS-Nr. VN6475000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29214300
Giftige Stoffe Daten 65-45-2(Hazardous Substances Data)
Toxizität LD50 orally in mice: 1.4 g/kg (Hart)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

2-Hydroxybenzamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Salicylamide is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group. It is absorbed from the GI tract on oral administration and is rapidly metabolized to inactive metabolites by intestinal mucosa, but not by hydrolysis. Activity appears to reside in the intact molecule. Salicylamide is approximately 40 to 55% plasma protein bound, and it competes with other salicylates and acetaminophen for glucuronide conjugation, decreasing the extent of conjugation of these other drugs.

Chemische Eigenschaften

white or light pink crystals or powder

Verwenden

Medicine (analgesic).

Verwenden

salicylamide is an analgesic, fungicide, and anti-inflammatory ingredient used to soothe the skin. Salicylamide is an aromatic amide.

Definition

ChEBI: The simplest member of the class of salicylamides derived from salicylic acid.

Allgemeine Beschreibung

Salicylamide, o-hydroxybenzamide, is a derivative of salicylicacid that is fairly stable to heat, light, and moisture. Itreportedly exerts a moderately quicker and deeper analgesiceffect than aspirin because of quicker CNS penetration. Its metabolismdiffers from aspirin, because it is not metabolized tosalicylic acid but rather excreted exclusively as the ether glucuronideor sulfate. Thus, as a result of lack of contributionfrom salicylic acid, it has a lower analgesic and antipyretic efficacythan that of aspirin. However, it can be used in place ofsalicylates for patients with a demonstrated sensitivity to salicylates.It is also excreted much more rapidly than other salicylates,which accounts for its lower toxicity. It is available inseveral nonprescription products, in combination with acetaminophenand phenyltoloxamine (e.g., Rid-A Pain compound,Cetazone T, Dolorex, Ed-Flex, Lobac) or with aspirin,acetaminophen, and caffeine (e.g., Saleto, BC Powder).

Allgemeine Beschreibung

Odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82°F) about 5. Sublimation begins at the melting point.

Air & Water Reaktionen

Salicylamide darkens on exposure to air. . Insoluble in water.

Reaktivität anzeigen

Salicylamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Salicylamide may be sensitive to prolonged exposure to light.

Brandgefahr

Flash point data for Salicylamide are not available; however, Salicylamide is probably combustible.

Clinical Use

Whereas salicylamide is reported to be as effective as aspirin as an analgetic/antipyretic and is effective in relieving pain associated with arthritic conditions, it does not appear to possess useful anti-inflammatory activity. Thus, indications for the treatment of arthritic disease states are unwarranted, and its use is restricted to the relief of minor aches and pain at a dosage of 325 to 650 mg three or four times per day. Its effects in humans are not reliable, however, and its use is not widely recommended.

läuterung methode

Crystallise the amide from water or repeatedly from CHCl3 [Nishiya et al. J Am Chem Soc 108 3880 1986]. [Beilstein 10 IV 169.] The anilide [87-17-2] M 213.2, m 135o crystallises from H2O. [Beilstein 12 H 500, 12 I 268, 12 II 256, 12 944.]

2-Hydroxybenzamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-Hydroxybenzamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 430)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

65-45-2(2-Hydroxybenzamid)Verwandte Suche:


  • 2-HYDROXYBENZAMIDE
  • Salicylamide o-Hydroxybenzamide Salamide
  • Deferasirox Benzamide Impurity
  • Salicylamide puriss., >=99.0% (T)
  • LABEIM-A
  • O-HYDROXYBENZAMIDE
  • Salamide
  • SALICYLAMIDE
  • 2-Carbamoylphenol
  • 2-hydroxy-benzamid
  • 2-hydroxy-benzoicaciamide
  • LABOTEST-BB LT02090583
  • Acket
  • Afko-Sal
  • Algamon
  • Algiamida
  • Allevin
  • Amid kyseliny salicylove
  • Salamid
  • Saliamid
  • Saliamin
  • Salicilamide
  • Salicim
  • Salicylamid
  • Salicylic Acid amide
  • salicylicacidamide
  • Salipur
  • Salizell
  • Salrin
  • Salymid
  • Samid
  • Serramida
  • sr4326
  • Urtosal
  • amidkyselinysalicylove
  • Amidosal
  • Amid-Sal
  • Anamid
  • Andasol
  • Benesal
  • Benzamide, o-hydroxy-
  • Benzamide,2-hydroxy-
  • Cetamide
  • Cidal
  • component of Tolagesic
  • Cymidon
  • Dolomide
  • Dropsprin
  • Eggosalil
  • Flarpirina
  • H.P. 34
  • h.p.34
  • Isonidrin
  • Liquiprin
  • Morsarinas
  • Novecyl
  • OHB
  • o-hydroxy-benzamid
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