chlorthenoxazine

chlorthenoxazine C화학적 특성, 용도, 생산

Originator

Reugaril ,Farber ,Italy ,1966

Manufacturing Process

A mixture of 4 liters chloroform and 1,050 cc ethanol was saturated with dry hydrogen chloride gas at -5°C to +5°C in a vessel having a net volume of 15 liters and provided with a stirring device, reflux cooler, gas feed line, thermometer and dropping funnel. 455 g acrolein which had been precooled to 0°C were added dropwise to the solution over a period of 1 to 2 hours while maintaining the temperature below +5°C and vigorously stirring. 1,070 g salicylamide and 1,080 g glacial acetic acid were added to the resulting solution of beta-chloropropionaldehyde acetal, thereby forming a suspension which was heated to 60°C while stirring. A clear solution was formed which was maintained at 60°C for an additional hour. The solution was allowed to cool to about 40°C and was then washed with water by passing a strong stream of water under the surface of the chloroform and continuously withdrawing the upper phase. When the water had reached a pH of 3-4, the precipitated reaction product was separated by vacuum filtration. The chloroform phase of the filtrate was evaporated under a weak vacuum and the residue was combined with the precipitate first obtained. The combined products were stirred with 2 liters of a 5% sodium hydroxide solution. The raw reaction product was then washed with water, dried and recrystallized from ethanol. The product had the melting point of 146°C to 147°C (decomposition). The yield was 1,260 g, corresponding to 76% of the theoretical yield.

Therapeutic Function

Antipyretic, Analgesic

chlorthenoxazine 준비 용품 및 원자재

원자재

준비 용품

chlorthenoxazine 공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aikon International Limited	025-66113011 18112977050	cb6@aikonchem.com	China	15495	58
Suzhou Rovathin Foreign Trade Co.,Ltd	0512-65816829 18662214788	info@rovathin.com.cn	China	9361	58
Amel Pharmatech Corporation	888-4366503	sales@amelpharmatech.com	China	5351	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3553	58
Shanghai Hecheng Medical Technology Co., LTD	13564747822	669027880@qq.com	China	957	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	15229059051	1027@dideu.com	China	9941	58

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