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8-Bromotheophylline

8-Bromotheophylline structure

CAS No.: 10381-75-6

Chemical Name:: 8-Bromotheophylline

Synonyms: Nsc164940;AKOS NCG-0005;bromotheophylline;8-Bromotheophyline;8-BROMOTHEOPHYLLINE;LABOTEST-BB LT00134545;Theophylline, 8-bromo-;8-BROMOTHEOPHYLLINE 97%;8-Bromotheophylline >8-Bromotheophylline ,97%

CBNumber:: CB0105862

Molecular Formula:: C7H7BrN4O2

Molecular Weight:: 259.06

MDL Number:: MFCD00022664

MOL File:: 10381-75-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-21 10:31:43

Product description	Number	Pack Size	Price
8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE Aldrich^CPR	S168378	1 unit	$121
8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE	1077708	400mg	$1270
8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE Aldrich	S168378	50mg	$110
8-Bromotheophylline >98.0%(HPLC)(T)	B3456	1g	$107
8-Bromotheophylline >98.0%(HPLC)(T)	B3456	5g	$328
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8-Bromotheophylline Properties

Melting point	295-297°C
Boiling point	469.5±55.0 °C(Predicted)
Density	1.862±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	pKa 5.45±0.1(H2O t=24) (Uncertain)
form	Solid
color	White to Off-White
BRN	203069
CAS DataBase Reference	10381-75-6
FDA UNII	FZG87K1MQ6
EPA Substance Registry System	1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-1,3-dimethyl- (10381-75-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Risk Statements	20/21/22
Safety Statements	24/25-36/37
RIDADR	2811
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	29395900

8-Bromotheophylline price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S168378	8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE Aldrich^CPR	10381-75-6	1 unit	$121	2026-03-19	Buy
Sigma-Aldrich	1077708	8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE	10381-75-6	400mg	$1270	2026-03-19	Buy
Sigma-Aldrich	S168378	8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE Aldrich	10381-75-6	50mg	$110	2024-03-01	Buy
TCI Chemical	B3456	8-Bromotheophylline >98.0%(HPLC)(T)	10381-75-6	1g	$107	2026-03-19	Buy
TCI Chemical	B3456	8-Bromotheophylline >98.0%(HPLC)(T)	10381-75-6	5g	$328	2026-03-19	Buy

Product number	Packaging	Price	Buy
S168378	1 unit	$121	Buy
1077708	400mg	$1270	Buy
S168378	50mg	$110	Buy
B3456	1g	$107	Buy
B3456	5g	$328	Buy

8-Bromotheophylline Chemical Properties,Uses,Production

Description

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980. It is also approved by Health Canada to be used alone or in combination with [DB00316] in OTC products.

Chemical Properties

White Crystalline Powder

Uses

The active component in the diuretic Diurex.

Synthesis

58-55-9

10381-75-6

The general procedure for the synthesis of 8-bromo-1,3-dimethyl-1H-purine-2,6(3H,9H)-dione using 1,3-dimethyl-1H-purine-2,6(3H,9H)-dione as a starting material was as follows: the theophylline (10 g, 55.5 mmol) was dissolved in a mixed solvent of acetic acid/water (90 mL of acetic acid, 60 mL of water) at 50 °C, followed by the bromine (9.76 g, 61 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously at 50 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature to induce precipitation of the target product. The precipitate was separated by filtration and the filter cake was washed twice with distilled water and subsequently dried under vacuum to afford 8-bromo-1,3-dimethyl-1H-purine-2,6(3H,9H)-dione (13.6 g, 94.5% yield) as a white solid. The product was detected by LCMS and showed MH+ peak of 259.

Purification Methods

It is purified by dissolving in the minimum volume of dilute NaOH (charcoal), filtering and acidifying to pH ca 3.5-4. The solid that separates is collected, dried in vacuo at 100o and stored in a dark container. It has also been recrystallised from EtOH or AcOH. [Blitz & Beck J Prakt Chem [2] 118 158 1928, Fischer & Ach Chem Ber 28 3142 1895, Beilstein 26 H 476, 26 II 227, 26 III/IV 2447.]

References

[1] Patent: US2014/275528, 2014, A1. Location in patent: Paragraph 0207; 0208
[2] Chemische Berichte, 1895, vol. 28, p. 3139
[3] Chemische Berichte, 1906, vol. 39, p. 430
[4] Justus Liebigs Annalen der Chemie, 1914, vol. 404, p. 164

8-Bromotheophylline Preparation Products And Raw materials

Raw materials

Acetic anhydride Theophylline Hydrogen bromide Nitric acid Acetic acid

Preparation Products

8-BROMO-7-(2,3-DIHYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE Purino[8,7-b]quinazoline-2,4,6(1H,3H,11H)-trione, 1,3-dimethyl- (9CI) 8-anilino-1,3-dimethyl-7H-purine-2,6-dione 8-BROMO-7-(3-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

8-Bromotheophylline Suppliers

Global( 144)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5899	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Labnetwork lnc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Coresyn Pharmatech Co., Ltd.	58
Golden Pharma Co., Limited	58

View Lastest Price from 8-Bromotheophylline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-21	8-Bromotheophylline 10381-75-6	US $29.00 / mL		98.49%	10g	TargetMol Chemicals Inc.
2021-07-02	8-Bromotheophylline 10381-75-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-01-22	8-BROMOTHEOPHYLLINE 10381-75-6	US $1.00 / KG	1KG	98%HPLC	10tons	Career Henan Chemical Co

8-Bromotheophylline
10381-75-6
US $29.00 / mL
98.49%
TargetMol Chemicals Inc.

8-Bromotheophylline
10381-75-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

8-BROMOTHEOPHYLLINE
10381-75-6
US $1.00 / KG
98%HPLC
Career Henan Chemical Co

8-Bromotheophylline Spectrum

8-Bromotheophylline(10381-75-6)¹HNMR

10381-75-6(8-Bromotheophylline)Related Search:

8-Bromotheophylline 8-BROMOXANTHINE 8-BROMO-7-ETHYL-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(3-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-BROMOPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 8-BROMO-1,3-DIMETHYL-7-(2-OXO-2-PHENYLETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE AKOS BC-1749

ETHYL 4-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)BUTANOATE 8-BROMO-1,3,7-TRIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE 8-BROMO-1,3-DIMETHYL-7-(2-OXOPROPYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-BROMOBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-1,3-DIMETHYL-7-PHENETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

8-BROMO-7-(2-CHLOROBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-HYDROXYBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

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8-bromo-3,7-dihydro-1,3-dimethyl-1h-purine-6-dione AKOS NCG-0005 8-BROMOTHEOPHYLLINE 8-BROMO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE 8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE LABOTEST-BB LT00134545 8-BROMOTHEOPHYLLINE 97% 1,3-Dimethyl-8-bromoxanthine bromotheophylline 8-Bromotheophylline ,97% 1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-1,3-dimethyl- 8-Bromotheophyline Nsc164940 Theophylline, 8-bromo- 8-bromo-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione(SALTDATA: FREE) 8-Bromotheophylline (400 mg) 8-BroMo-1,3-diMethyl-1H-purine-2,6(3H,9H)-dione 8-broMo-1,3-diMethyl-1H-purine-2,6(3H,7H)-dione 8-Bromo-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 8-bromo-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione 8-Bromotheophylline, ≥98% 8-Bromotheophylline > 1H-Purine-2,6-dione, 8-bromo-3,9-dihydro-1,3-dimethyl- 8-Bromotheophylline (1077708) 8-Bromotheophylline, 10 mM in DMSO 10381-75-6 C7H7BrN4O2 Pharmaceutical Raw Materials Nucleotides and Nucleosides Bases & Related Reagents Nucleotides