3-CHLORO-5-HYDROXY-BENZOIC ACID
- CAS No.
- 53984-36-4
- Chemical Name:
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
- Synonyms
- 3-chloro-5-hydroxy BA;GPR81 Agonist, 3Cl-5OH-BA;5-Chloro-m-salicylic Acid;3-CHLORO-5-HYDROXY-BENZOIC ACID;5-(hydroxy)-3-chlorobenzoic acid;Benzoic acid, 3-chloro-5-hydroxy-;GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem
- CBNumber:
- CB0129376
- Molecular Formula:
- C7H5ClO3
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD04114327
- MOL File:
- 53984-36-4.mol
| Melting point | 244.0 to 248.0 °C |
|---|---|
| Boiling point | 364.8±27.0 °C(Predicted) |
| Density | 1.536±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: soluble15mg/mL (clear solution) |
| form | powder |
| pka | 3.71±0.10(Predicted) |
| color | white to beige |
| InChIKey | RJOLIYHZZKAIET-UHFFFAOYSA-N |
| CAS DataBase Reference | 53984-36-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
3-CHLORO-5-HYDROXY-BENZOIC ACID price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0447 | 3-Chloro-5-hydroxybenzoic acid ≥97% (HPLC) | 53984-36-4 | 25mg | $309 | 2023-01-07 | Buy |
| TCI Chemical | C3183 | 3-Chloro-5-hydroxybenzoic Acid >98.0%(GC)(T) | 53984-36-4 | 1g | $116 | 2024-03-01 | Buy |
| TCI Chemical | C3183 | 3-Chloro-5-hydroxybenzoic Acid >98.0%(GC)(T) | 53984-36-4 | 5g | $391 | 2024-03-01 | Buy |
| Cayman Chemical | 16795 | 3-chloro-5-hydroxy BA ≥98% | 53984-36-4 | 25mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16795 | 3-chloro-5-hydroxy BA ≥98% | 53984-36-4 | 50mg | $61 | 2024-03-01 | Buy |
3-CHLORO-5-HYDROXY-BENZOIC ACID Chemical Properties,Uses,Production
Uses
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]
Uses
5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects.
Biological Activity
3-chloro-5-hydroxy ba is a gpr81 agonist.gpr81 (hca1) is a member of g-protein-coupled receptors (gpcrs). gpr81 is predominantly expressed on adipocytes and is activated by the endogenous ligands 2-hydroxypropanoate (lactate). stimulation of gpr81 in adipose tissue lead to a decrease in the lipolysis of triglycerides by hormone-sensitive lipase, which resulted in reduced transport of fatty acids to the liver and a decrease in hepatic triglycerides [1].
in vitro
in the hgpr81 assay, 3-chloro-5-hydroxybenzoic acid showed the potency against gpr81 with an ec50 of 16 μm. the ec50 of 3-chloro-5-hydroxybenzoic acid against monkey gpr81, dog gpr81, rat gpr81, mouse gpr81, and hamster gpr81 was 17 μm, 67 μm, 7 μm, 22 μm and 27 μm, respectively [1]. 3-chloro-5-hydroxy ba blocked basal ghrelin secretion by primary gastric mucosal cells [2].
in vivo
in mice, oral administration of 3-chloro-5-hydroxybenzoic acid at 30 mg/kg provided a cmax of 67 μm at approximately 3-fold over the in vitro ec50 with an aucinf of 54 h μm and a short t1/2 of 1.5 h, and the 100 mg/kg p.o dose attained a cmax of 342 μm at greater than 15-fold over the observed in vitro ec50 [1].
References
[1]. dvorak c a, liu c, shelton j, et al. identification of hydroxybenzoic acids as selective lactate receptor (gpr81) agonists with antilipolytic effects[j]. acs medicinal chemistry letters, 2012, 3(8): 637-639.
[2]. engelstoft m s, park w, sakata i, et al. seven transmembrane g protein-coupled receptor repertoire of gastric ghrelin cells[j]. molecular metabolism, 2013, 2(4): 376-392.
3-CHLORO-5-HYDROXY-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 13854 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from 3-CHLORO-5-HYDROXY-BENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-03-26 | 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
|
US $3.00-0.20 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2022-09-23 | 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
|
US $100.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
- US $3.00-0.20 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
53984-36-4
- US $100.00 / KG
- 98%
- Career Henan Chemical Co
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