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phosphoramide mustard

phosphoramide mustard structure

CAS No.: 10159-53-2

Chemical Name:: phosphoramide mustard

Synonyms: phosphoramide mustard;Phosphoramide Mustard D8

CBNumber:: CB01386806

Molecular Formula:: C4H11Cl2N2O2P

Molecular Weight:: 221.02

MDL Number:

MOL File:: 10159-53-2.mol

MSDS File:: SDS

Last updated:2023-05-04 17:34:30

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phosphoramide mustard Properties

Melting point	115 °C
Boiling point	363.5±52.0 °C(Predicted)
Density	1.474±0.06 g/cm3(Predicted)
pka	0.41±0.50(Predicted)
FDA UNII	4K9ULD24RM

SAFETY

Risk and Safety Statements

Toxicity	LD50 intraperitoneal in mouse: 184mg/kg

phosphoramide mustard Chemical Properties,Uses,Production

Definition

ChEBI: Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.

Biological Activity

Phosphoramide mustard is the active metabolite of cyclophosphamide (HY-17420) with antitumor activity. It induces DNA damage.

in vitro

Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
It (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells ( SIGCs).
Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
It (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.

Cell Viability Assay

Cell Line:	SIGCs
Concentration:	0.5 μM, 1 μM, 3 μM, 6 μM
Incubation Time:	48 hours
Result:	Reduced ce ll viability at concentrations of 3 μM and higher.

RT-PCR

Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Increased DDR gene mRNA expression levels.

Western Blot Analysis

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Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Generally increased DDR pro teins.

target

DNA Alkylator

phosphoramide mustard synthesis

Synthesis of phosphoramide mustard from N-(amino-phenoxy-phosphoryl)-2-chloro-N-(2-chloroethyl)ethanamine

phosphoramide mustard Preparation Products And Raw materials

Raw materials

N-(amino-phenylmethoxy-phosphoryl)-2-chloro-N-(2-chloroethyl)ethanamine N-(amino-phenoxy-phosphoryl)-2-chloro-N-(2-chloroethyl)ethanamine

Preparation Products

phosphoramide mustard Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9503	50
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9288	58
Guangzhou Yunmen Biotechnology Co., Ltd	18902340307 18902340307	3356812514@qq.com	China	9238	58
Guangdong Fangxin Biotechnology Co., Ltd.	0751-2838688 13376594225	1276075424@qq.com	China	9934	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
AFINE CHEMICALS LIMITED	58
PT CHEM GROUP LIMITED	58
Chizhou Kailong Import and Export Trade Co., Ltd.	50
Shenzhen Regent Biochemical Technology Co., Ltd.	58
Guangzhou Yunmen Biotechnology Co., Ltd	58
Guangdong Fangxin Biotechnology Co., Ltd.	58

10159-53-2(phosphoramide mustard)Related Search:

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phosphoramide mustard Phosphoramide Mustard D8 10159-53-2