LACTUCIN
- CAS No.
- 1891-29-8
- Chemical Name:
- LACTUCIN
- Synonyms
- LACTUCIN;Lactucine;(3aR)-3,3aβ,4,5,9aβ,9bα-Hexahydro-4α-hydroxy-9-(hydroxymethyl)-6-methyl-3-methyleneazuleno[4,5-b]furan-2,7-dione;(3aR,4S,9aS,9bR)-3,3a,4,5,9a,9b-Hexahydro-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methyleneazuleno[4,5-b]furan-2,7-dione;(3aR,4S,9aS,9bR)-4-Hydroxy-9-(hydroxymethyl)-6-methyl-3-methylene-3,3a,4,5-tetrahydroazuleno[4,5-b]furan-2,7(9aH,9bH)-dione;Azuleno[4,5-b]furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylene-, (3aR,4S,9aS,9bR)-
- CBNumber:
- CB01435898
- Molecular Formula:
- C15H16O5
- Molecular Weight:
- 276.28
- MDL Number:
- MFCD24849263
- MOL File:
- 1891-29-8.mol
- MSDS File:
- SDS
| Melting point | 228-233° |
|---|---|
| alpha | D +49° (c = 0.90 in methanol), +77.9° (c = 3.44 in pyridine) |
| Boiling point | 575.6±50.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 13.53±0.60(Predicted) |
| form | solid |
| InChI | 1S/C15H16O5/c1-6-3-9(17)12-7(2)15(19)20-14(12)13-8(5-16)4-10(18)11(6)13/h4,9,12-14,16-17H,2-3,5H2,1H3/t9-,12+,13-,14-/m0/s1 |
| InChIKey | VJQAFLAZRVKAKM-VZLIPTOUSA-N |
| SMILES | O1[C@H]2[C@@H]([C@H](CC(=C3[C@@H]2C(=CC3=O)CO)C)O)C(=C)C1=O |
| LogP | 0.330 (est) |
| CAS DataBase Reference | 1891-29-8 |
| FDA UNII | R6E2918904 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280-P302+P352 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Skin Sens. 1 |
LACTUCIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL84795 | Lactucin phyproof? Reference Substance | 1891-29-8 | 5MG | $419 | 2026-04-30 | Buy |
| ChemScene | CS-0169537 | Lactucin 99.72% | 1891-29-8 | 1mg | $399 | 2026-06-04 | Buy |
| ChemScene | CS-0169537 | Lactucin 99.72% | 1891-29-8 | 5mg | $997 | 2026-06-04 | Buy |
| aablocks | AA00AQJA | Lactucin >98% | 1891-29-8 | 1mg | $444 | 2026-05-28 | Buy |
| aablocks | AA00AQJA | Lactucin >98% | 1891-29-8 | 5mg | $1058 | 2026-05-28 | Buy |
LACTUCIN Chemical Properties, Uses, Production
Description
Lactucin, as lactucopicrin, is a sesquiterpene lactone contained in lettuce (Lactuca sativa).
Uses
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4].
Definition
ChEBI: An azulenofuran that is 3-methylidene-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione carrying additional hydroxy, methyl and hydroxymethyl substituents at positions 4, 6 and 9 respectively (the 3aR,4S,9 S,9bR-diastereomer). Found in chicory.
Contact allergens
Lactucin, as lactucopicrin, is a sesquiterpene lactone contained in lettuce (Lactuca sativa L.)
in vivo
Lactucin (15 and 30 mg/kg; i.p.; once) decreases the spontaneous locomotor activity and shows analgesic properties in mice[2].
| Animal Model: | Male Albino-Swiss mice (18-24 g)[2] |
| Dosage: | 15 and 30 mg/kg |
| Administration: | Intraperitoneal injection, once |
| Result: | Decreased the spontaneous locomotor activity and showed analgesic properties in the hot plate test. |
References
[1] Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170. DOI:10.1016/j.fitote.2019.104170
[2] Gromek D, et al. Biologically active preparations from Lactuca virosa L. Phytotherapy Research, 1992, 6(5): 285-287.
[3] Zhang F H, et al. Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest. Bangladesh Journal of Pharmacology, 2016, 11(2): 478-484.
[4] Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95(2-3):455-7. DOI:10.1016/j.jep.2004.06.031
LACTUCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8561 | 60 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 10059 | 58 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4932 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684; | sales@rrkchem.com | China | 57330 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5035 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Chengdu Alfa Biotechnology Co.,Ltd. | 028-028-85142057 19983342022 | 3591697873@qq.com | China | 1976 | 58 |
| ChengDu YiRui Bio-Technology CO., LTD | 18224028459 18224028459 | yirui307@163.com | China | 995 | 58 |
