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2-Deoxy-D-glucose

2-Deoxy-D-glucose
2-Deoxy-D-glucose structure
CAS No.
154-17-6
Chemical Name:
2-Deoxy-D-glucose
Synonyms
2-dg;ba2758;D-2dGlc;nsc15193;deoxyglucose;2-deoxy-glucos;2-DEOXYGLUCOSE;D-2-GLUCODESOSE;2-deoxy-d-glucos;d-2-deoxyglucose
CBNumber:
CB0251338
Molecular Formula:
C6H12O5
Formula Weight:
164.16
MOL File:
154-17-6.mol

2-Deoxy-D-glucose Properties

Melting point:
146-147 °C(lit.)
alpha 
45.5 º (c=2, H2O)
Boiling point:
211.61°C (rough estimate)
Density 
1.1738 (rough estimate)
refractive index 
46.5 ° (C=1, H2O)
storage temp. 
0-6°C
solubility 
H2O: 50 mg/mL, clear, colorless to faintly yellow
form 
crystalline
pka
pK1:12.52 (25°C)
color 
white
Water Solubility 
Soluble in water.
Merck 
14,2904
BRN 
1723331
InChIKey
PMMURAAUARKVCB-CEZCPVKQSA-N
CAS DataBase Reference
154-17-6(CAS DataBase Reference)
EPA Substance Registry System
D-arabino-Hexose, 2-deoxy-(154-17-6)

SAFETY

Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-37/39-36-26
WGK Germany  3
RTECS  MQ3325000
3-10
TSCA  Yes
HS Code  29400090
Hazardous Substances Data 154-17-6(Hazardous Substances Data)

2-Deoxy-D-glucose price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D3179 2-Deoxy-D-glucose BioXtra, ≥98% 154-17-6 1g $187 2018-11-20 Buy
Sigma-Aldrich 1171251 2-Deoxy-D-glucose United States Pharmacopeia (USP) Reference Standard 154-17-6 100mg $360.15 2018-11-20 Buy
TCI Chemical D0051 2-Deoxy-D-glucose >97.0%(GC) 154-17-6 1g $38 2018-11-22 Buy
TCI Chemical D0051 2-Deoxy-D-glucose >97.0%(GC) 154-17-6 5g $115 2018-11-22 Buy
Alfa Aesar L07338 2-Deoxy-D-glucose, 98% 154-17-6 1g $46.6 2018-11-15 Buy

2-Deoxy-D-glucose Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.[Cayman Chemical]

Safety Profile

Poison by subcutaneous route. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes.

Purification Methods

Crystallise 2-deoxy--D-glucose from MeOH/Me2CO, Me2CO or butanone to give a mixture of  and  anomers, m 142-144o, [] 18 +38o (35minutes) to +46o (c 0.5, H2O). Recrystallisation from isoPrOH gives mainly the -anomer m 134-136o , [ ] D +156o to +103o (c 0.9, pyridine). 1H NMR studies showed that at 44o in D2O the solution contained 36% of -pyranose and 64% of -pyranose sugar, but furanose structures were undetectable. [Snowden & Fischer J Am Chem Soc 69 1048 1947, derivatives: Bollinger & Schmidt Helv Chim Acta 34 989 1951; see Angyal & Pickles Aust J Chem 25 1711 1972 for ratio of isomers in solution, Beilstein 1 IV 4282.]

2-Deoxy-D-glucose Preparation Products And Raw materials

Raw materials

Preparation Products


2-Deoxy-D-glucose Suppliers

Global( 321)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Beijing Ribio Biotech Co.,Ltd
010-62664360
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Hebei Guanlang Biotechnology Co., Ltd.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51086038
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Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
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Yunbio Tech Co.,Ltd.
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Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
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View Lastest Price from 2-Deoxy-D-glucose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-09 2-Deoxy-D-glucose
154-17-6
US $100.00 / KG 100g 99.8% 5tons Hebei Jimi Trading Co., Ltd.
2018-07-27 2-Deoxy-D-glucose
154-17-6
US $29.00 / KG 10KG 99% 10000kg career henan chemical co
2018-11-01 2-Deoxy-D-glucose
154-17-6
US $50.00 / KG 1KG 99% 10 MT Hebei Huanhao Biotechnology Co., Ltd.

2-Deoxy-D-glucose Spectrum


154-17-6(2-Deoxy-D-glucose)Related Search:


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  • Monosaccharide
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