(R)-(+)-2-Methyl-2-propanesulfinamide
- CAS No.
- 196929-78-9
- Chemical Name:
- (R)-(+)-2-Methyl-2-propanesulfinamide
- Synonyms
- (R)-2-METHYLPROPANE-2-SULFINAMIDE;(R)-TERT-BUTANESULFINAMIDE;(R)-2-METHYL-2-PROPANESULFINAMIDE;Trityl glycidyl ether;(R)-N-tert-Butanesulfinamide;DASO-002;Borax LR;R-(+)-TBSA;-2-propanesuL;Nicotinamide Impurity 18
- CBNumber:
- CB2765464
- Molecular Formula:
- C4H11NOS
- Molecular Weight:
- 121.2
- MDL Number:
- MFCD05861479
- MOL File:
- 196929-78-9.mol
- MSDS File:
- SDS
Melting point | 103-107 °C(lit.) |
---|---|
Boiling point | 220.0±23.0 °C(Predicted) |
alpha | 4 º (c=1, CHCl3 + amylenes) |
Density | 0.903 g/mL at 25 °C |
refractive index | 4 ° (C=1, CHCl3) |
Flash point | -17℃ |
storage temp. | 2-8°C |
solubility | Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents. |
form | Powder |
pka | 10.11±0.50(Predicted) |
color | White, light pink, light yellow to brown |
optical activity | [α]22/D +1.0°, c = 0.5% in chloroform |
Stability | store cold |
InChIKey | CESUXLKAADQNTB-SSDOTTSWSA-N |
CAS DataBase Reference | 196929-78-9(CAS DataBase Reference) |
FDA UNII | 7FEC1T720F |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H225-H302-H319-H335-H351 | |||||||||
Precautionary statements | P210-P280-P301+P312+P330-P305+P351+P338-P370+P378-P403+P235 | |||||||||
Hazard Codes | Xi,Xn,F | |||||||||
Risk Statements | 11-19-36/37-40-36/37/38 | |||||||||
Safety Statements | 22-24/25-36/37-26-16-36/37/39 | |||||||||
RIDADR | UN 2056 3 / PGII | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant/Keep Cold | |||||||||
TSCA | No | |||||||||
HS Code | 29309090 | |||||||||
NFPA 704 |
|
(R)-(+)-2-Methyl-2-propanesulfinamide price More Price(68)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 497401 | (R)-(+)-2-Methyl-2-propanesulfinamide 98% | 196929-78-9 | 1g | $85 | 2024-03-01 | Buy |
Sigma-Aldrich | 497401 | (R)-(+)-2-Methyl-2-propanesulfinamide 98% | 196929-78-9 | 5g | $172 | 2024-03-01 | Buy |
TCI Chemical | B2907 | (R)-(+)-tert-Butylsulfinamide >98.0%(GC) | 196929-78-9 | 1g | $59 | 2024-03-01 | Buy |
TCI Chemical | B2907 | (R)-(+)-tert-Butylsulfinamide >98.0%(GC) | 196929-78-9 | 5g | $175 | 2024-03-01 | Buy |
Alfa Aesar | H27724 | (R)-(+)-2-Methyl-2-propanesulfinamide, 98% | 196929-78-9 | 1g | $60.65 | 2024-03-01 | Buy |
(R)-(+)-2-Methyl-2-propanesulfinamide Chemical Properties,Uses,Production
Chemical Properties
(R)-(+)-2-Methyl-2-propanesulfinamide is white to light yellow crystal powde
Uses
suzuki reaction, useful reagent for synthesizing chiral amines.
Uses
Chiral ligand used in pharmaceutical compositions
Uses
(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.
Preparation
Acetic acid (70 g), R-tert-butylsulfinylhydrazine (42 g), zinc powder (60.5 g) and dichloromethane (150 mL) were added to the reaction flask. The temperature was slowly heated to 35-42 °C . After 16 hours, the filtrate was poured into 70 mL water. Dichloromethane (75 g×5) was added for extraction. Collected the organic phase, added 48% NaOH to adjust ρΗ (7-8). Then added NaCl, the layers were separated and the organic phase was washed with 15 g saturated aqueous solution of sodium chloride. The solution was dried over magnesium sulfate. After filterED, filtrate was concentrated under reduced pressure at 25-30 °C until no slipping. N-heptane was replaced, 28 g mixed solvent of N-heptane and toluene (N-heptane: toluene = 6:1) were added to perform beating at low temperature, filtered to obtain (R)-(+)-2-Methyl-2-propanesulfinamide. Yield=83%
References
[1] Qian X, et al. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist. Tetrahedron, 2015; 71: 9408-9414.
(R)-(+)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials
Raw materials
1of6
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou uniringchem Co., Ltd. | +undefined13585446801 | sales@uniringchem.com | China | 68 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12465 | 58 |
Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1227 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7193 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
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View Lastest Price from (R)-(+)-2-Methyl-2-propanesulfinamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | (R)-(+)-2-Methyl-2-propane sulfinamide
196929-78-9
|
US $10.00-90.00 / g | 5g | 0.98 | 25kg | Shanghai UCHEM Inc. | ||
2024-06-11 | (R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
|
US $0.00-0.00 / G | 10G | 0.98 | 500kg | Kindchem(Nanjing)Co.,Ltd | ||
2023-07-29 | (R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
|
US $50.00 / KG | 1KG | 99% | 20tons | Hebei Mojin Biotechnology Co., Ltd |
- (R)-(+)-2-Methyl-2-propane sulfinamide
196929-78-9
- US $10.00-90.00 / g
- 0.98
- Shanghai UCHEM Inc.
- (R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
- US $0.00-0.00 / G
- 0.98
- Kindchem(Nanjing)Co.,Ltd
- (R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
- US $50.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd