Ciprofloxacin hydrochloride
- CAS No.
- 93107-08-5
- Chemical Name:
- Ciprofloxacin hydrochloride
- Synonyms
- CIPROFLOXACIN HCL;CIPROFLOXACIN HYDROCHLORIDE;1-Cyclopropyl-6-fluoro;1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride;Cyproxan;BAY-o-9867;Bay-09867 (hydrochloride);Clprofloxacin hydrochloride;Ciprofloxacin hydrochloride
- CBNumber:
- CB02130396
- Molecular Formula:
- C17H18FN3O3.HCl
- Molecular Weight:
- 367.8
- MDL Number:
- MOL File:
- 93107-08-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 ºC |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | insoluble in EtOH; ≥33.87 mg/mL in H2O; ≥9.34 mg/mL in DMSO with ultrasonic |
| form | crystalline solid |
| color | White to off-white |
| BCS Class | 3 |
| InChI | InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H |
| InChIKey | DIOIOSKKIYDRIQ-UHFFFAOYSA-N |
| SMILES | O=C(O)C1C(=O)C2=CC(=C(C=C2N(C2CC2)C=1)N1CCNCC1)F.[H]Cl |
| CAS DataBase Reference | 93107-08-5 |
| FDA UNII | 0MP32MFP6C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| HS Code | 29339900 |
Ciprofloxacin hydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14286 | Ciprofloxacin (hydrochloride) ≥95% | 93107-08-5 | 5g | $28 | 2022-04-27 | Buy |
| Cayman Chemical | 14286 | Ciprofloxacin (hydrochloride) ≥95% | 93107-08-5 | 10g | $53 | 2022-04-27 | Buy |
| Biosynth | FC178490 | Ciprofloxacin hydrochloride | 93107-08-5 | 100g | $243 | 2026-06-04 | Buy |
| Biosynth | FC178490 | Ciprofloxacin hydrochloride | 93107-08-5 | 250g | $377.5 | 2026-06-04 | Buy |
| Biosynth | FC178490 | Ciprofloxacin hydrochloride | 93107-08-5 | 500g | $605 | 2026-06-04 | Buy |
Ciprofloxacin hydrochloride Chemical Properties,Uses,Production
Description
Ciprofloxacin hydrochloride is the hydrochloride of ciprofloxacin, which is a synthetic second-generation quinolone antibacterial drug with broad-spectrum antibacterial activity and good bactericidal effect. It is 2 to 4 times stronger than enoxacin, and has antibacterial effects on Enterobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, and Staphylococcus aureus.
Mechanism of action
Ciprofloxacin hydrochloride is a new type of quinolone antibacterial drug. Its mechanism of action is that it can combine with bacterial DNA gyrase subunit A, thereby inhibiting the cleavage and linking functions of the enzyme, preventing the replication of bacterial DNA, and showing antibacterial effect.
Uses
Ciprofloxacin hydrochloride, C17H18FN3O3 •HCl•H2O, is a synthetic broad-spectrum antibacterial agent. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. it was the drug of choice forcombating anthrax.
Ciprofloxacin hydrochloride (Cipro, 500-mg tablets) is highly active against the important bacterial causes of enteritis, including diarrheogenic Escherichia coli, Vibrio cholerae, Salmonella species, Shigella species, Campylobacter jejuni, Aeromonas species, and Yersinia enterocolitica.
Uses
Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic that is widely used as an antimicrobial and immunomodulatory agent. Its range of activity includes most strains of bacterial pathogens capable of inducing respiratory, urinary tract, gastrointestinal, and abdominal infections. It functions by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Most recently Ciprofloxacin hydrochloride has been used in the management of postexposure inhalational anthrax and radiation combined injury resulting from nuclear disasters.[Cayman Chemical]
Uses
Anti-bacterial
Definition
ChEBI: Ciprofloxacin hydrochloride (anhydrous) is the anhydrous form of the monohydrochloride salt of ciprofloxacin. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antibacterial drug, a topoisomerase IV inhibitor and an antiinfective agent. It contains a ciprofloxacin.
brand name
Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit).
Biological Activity
ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].ciprofloxacin functions by inhibiting dna gyrase and topoisomerase iv, the enzymes responsible for negative supercoiling of chromosomes and dna strand separation, thus blocking initiation of bacterial replication. topoisomerase iv is the primary target of ciprofloxacin in s. aureus [2].ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that acts as an antimicrobial and immunomodulatory agent. in b6d2f1/j mice received radiation combined injury (ci), ciprofloxacin significantly reduced pro-inflammatory cytokine and chemokine concentrations (il-6 and kc), and enhanced il-3 production. cip also inhibited ci-induced apoptosis and autophagy in ileal villi, systemic bacterial infection, and iga production [1]. ciprofloxacin (hydrochloride) had been approved by fda for management of postexposure inhalational anthrax. in animals after exposure to aerosolized b. anthracis, ciprofloxacin significantly improved survival rate. ciprofloxacin inhibited the growth of b. anthracis with mic90 of 0.06 μg/ml. in the usamriid rhesus monkey model of inhalational anthrax, the maximum concentration (cmax) of ciprofloxacin was 1.74 μg/ml and the minimum concentration (cmin) was 0.17 μg/ml [3].
Synthesis
The preparation method of ciprofloxacin HCl, its step is as follows:
a) cyclopropyl carboxylic acid is added in the organic solvent, and the adding piperazine, reacted 3～8 hours down as acid binding agent with alkali at 60～120 ℃, the monitoring cyclopropyl carboxylic acid is residual less than 2% o'clock termination reaction, stirring is cooled to 0～30 ℃, leaves standstill suction filtration;
b) add water and hydrochloric acid in the products therefrom toward a) step, under agitation be warming up to molten clearly, add activated carbon decolorizing, filtered while hot, and transfer filtrate pH to 2～4 with hydrochloric acid, and the cooling crystallization filters, rinsing, and drying makes ciprofloxacin HCl.
References
[1]. fukumoto r, cary lh, gorbunov nv, et al. ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma. plos one. 2013;8(3):e58389.
[2]. drlica k, zhao x. dna gyrase, topoisomerase iv, and the 4-quinolones. microbiol mol biol rev. 1997 sep;61(3):377-92.
[3]. meyerhoff a, albrecht r, meyer jm, et al. us food and drug administration approval of ciprofloxacin hydrochloride for management of postexposure inhalational anthrax. clin infect dis. 2004 aug 1;39(3):303-8.
Ciprofloxacin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Huajiu Pharmaceutical Technology Co.,Ltd. | 027-59225746 18062681621 | 730880265@qq.com | China | 4800 | 58 |
| HIGH HOPE INTERNATIONAL GROUP JIANGSU MEDICINES AND HEALTH PRODUCTS IMPORT AND EXPORT CORPORATION | 025-84691373 15312418043 | yxq@mehecojs.com | China | 117 | 58 |
| Hubei widely chemical technology Co., Ltd. | 027-83991130 18627774460 | 1718093273@QQ.COM | China | 1618 | 58 |
| Jiangsu Rongshuo Pharmaceutical Co., Ltd | 0000-15105138935 15105138935 | 2622104407@qq.com | China | 99 | 58 |
| Shandong Qingxu Biotechnology Co., Ltd. | 18039551173 18039551173 | 3066129641@qq.COM | China | 266 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
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View Lastest Price from Ciprofloxacin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | Ciprofloxacin HCl
93107-08-5
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-09-01 | Ciprofloxacin Hydrochloride
93107-08-5
|
1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-08-20 | Ciprofloxacin HCl
93107-08-5
|
$1.10 | 1g | 99.9% Min | 100 Tons | Dideu Industries Group Limited |
-
- Ciprofloxacin HCl
93107-08-5
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Ciprofloxacin Hydrochloride
93107-08-5
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Ciprofloxacin HCl
93107-08-5
- $1.10
- 99.9% Min
- Dideu Industries Group Limited
