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4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide structure

CAS No.: 101574-65-6

Chemical Name:: 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide

Synonyms: CS-1084;GSK-4716, 10 mM in DMSO;GSK 4716, ERRbetagamma agonist;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide;4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide;2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid;4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide

CBNumber:: CB02446303

Molecular Formula:: C17H18N2O2

Molecular Weight:: 282.34

MDL Number:: MFCD00567155

MOL File:: 101574-65-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:48:00

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4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide Properties

Density	1.12
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: >10mg/mL
form	powder
pka	8.48±0.15(Predicted)
color	white to off-white
InChI	1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
InChIKey	IKPPIUNQWSRCOZ-WOJGMQOQSA-N
SMILES	CC(C)c1ccc(cc1)\C=N\NC(=O)c2ccc(O)cc2
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H317-H410
Precautionary statements	P261-P272-P273-P280-P302+P352-P333+P313
Hazard Codes	Xi,N
Risk Statements	43-50/53
Safety Statements	36/37-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HazardClass	9
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1 Skin Sens. 1

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G6173	GSK 4716 ≥98% (HPLC)	101574-65-6	10mg	$111	2025-07-31	Buy
Sigma-Aldrich	G6173	GSK 4716 ≥98% (HPLC)	101574-65-6	50mg	$438	2025-07-31	Buy
Cayman Chemical	17233	GSK4716 ≥98%	101574-65-6	5mg	$44	2026-04-30	Buy
Cayman Chemical	17233	GSK4716 ≥98%	101574-65-6	10mg	$71	2026-04-30	Buy
Cayman Chemical	17233	GSK4716 ≥98%	101574-65-6	50mg	$304	2026-04-30	Buy

Product number	Packaging	Price	Buy
G6173	10mg	$111	Buy
G6173	50mg	$438	Buy
17233	5mg	$44	Buy
17233	10mg	$71	Buy
17233	50mg	$304	Buy

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide Chemical Properties, Uses, Production

Description

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC₅₀ = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.

Uses

Selective agonist at estrogen-related receptors ERR and ERR

Uses

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]

Definition

ChEBI: GSK 4716 is a monoterpenoid.

Biological Activity

Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.

storage

Store at +4°C

References

[1] LIPING WANG. X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.[J]. The Journal of Biological Chemistry, 2006: 37773-37781. DOI: 10.1074/jbc.m608410200
[2] SHAMINA M RANGWALA. Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity.[J]. The Journal of Biological Chemistry, 2010, 285 29: 22619-22629. DOI: 10.1074/jbc.m110.125401

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide Suppliers

Global Suppliers ( 96)

Supplier	Tel	Email	Country	ProdList	Advantage
Yichang Chanod Biomedical Technology Co,LTD	0717-6855399 15377615856	sales@chanodpharm.com	China	71	58
Zhuhai Huachen Pharmaceutical Technology Co., Ltd	15916275916	290113728@qq.com	China	52	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16307	64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
ShangHai KenEn Chemical Technology Co., Ltd.	13120367189;18621755571	mychess007@163.com	China	1994	55
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9781	50
Chengdu YouSuo Biotechnology Limited	13693449011	83948782@qq.com	China	92	50
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4864	55

Supplier	Advantage
Yichang Chanod Biomedical Technology Co,LTD	58
Zhuhai Huachen Pharmaceutical Technology Co., Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
VDM Biochemicals	64
Nanjing Chemlin Chemical Co., Ltd	64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
ShangHai KenEn Chemical Technology Co., Ltd.	55
Shanghai HuanChuan Industry Co.,Ltd.	50
Chengdu YouSuo Biotechnology Limited	50
Shanghai Lollane Biological Technology Co.,Ltd.	55

View Latest Price from 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	GSK-4716 101574-65-6	$58.00-228.00		99.53%	10g	TargetMol Chemicals Inc.
	2019-09-02	4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE 101574-65-6	$1.00	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

GSK-4716
101574-65-6
$58.00-228.00
99.53%
TargetMol Chemicals Inc.

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
101574-65-6
$1.00
98%
Career Henan Chemical Co

4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide Spectrum

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE(101574-65-6)¹HNMR

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4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide

1of3

(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide 4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide CS-1084 Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide 4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide GSK 4716, ERRbetagamma agonist GSK-4716, 10 mM in DMSO 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide 101574-65-6 Selective agonist at estrogen-related receptors ERRβ and ERRγ.