Selonsertib
- CAS No.
- 1448428-04-3
- Chemical Name:
- Selonsertib
- Synonyms
- GS 4997;GS-4497;CS-2217;Selonsertib;GS-4997;ASK-1;GS4997;GS 4997;GS4997 SELONSERTIB;Selonsertib GS-4997;Selonsertib free base.;Selonsertib (Synonyms: GS-4997)
- CBNumber:
- CB03122039
- Molecular Formula:
- C24H24FN7O
- Molecular Weight:
- 445.49
- MDL Number:
- MFCD29920355
- MOL File:
- 1448428-04-3.mol
| Melting point | >180°C (dec.) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| pka | 11.21±0.70(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 1448428-04-3 |
| FDA UNII | NS3988A2TC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373 | |||||||||
| Precautionary statements | P260-P314-P501 | |||||||||
| NFPA 704 |
|
Selonsertib price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20972 | Selonsertib ≥95% | 1448428-04-3 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20972 | Selonsertib ≥95% | 1448428-04-3 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 20972 | Selonsertib ≥95% | 1448428-04-3 | 5mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 20972 | Selonsertib ≥95% | 1448428-04-3 | 10mg | $335 | 2024-03-01 | Buy |
| TRC | S253800 | Selonsertib | 1448428-04-3 | 10mg | $315 | 2021-12-16 | Buy |
Selonsertib Chemical Properties,Uses,Production
Description
Selonsertib (1448428-04-3) is a potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis2-4. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2.5
Uses
Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.
in vitro
gs-4997 has been identified as a highly selective and potent ask1 inhibitor that competed with atp in the ask1 catalytic kinase domain. moreover, the ask1 inhibition caused by gs-4997 was found to be significantly different in mechanism from bardoxolone methyl. gs- 4997 could also shut down cell signaling involved in pathogenesis, while bardoxolone methyl activated mrna transcription in every cell exposed to drug. in addition, gs-4997 could selectively target affected cells in which the oxidative burden was high [1].
References
Lanier et al. (2017), Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure; ACS Med. Chem. Lett. 8 316 Loomba et al. (2017), The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial; Hepatology 67 549 Younossi et al. (2018), Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib; Liver Int. 38 1849 Gawrieh and Chalasani (2018), Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis; Clin. Liver Dis. 22 189 Ji et al. (2019), Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells; Cancer Lett. 440-441 82
Selonsertib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
View Lastest Price from Selonsertib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | Selonsertib
1448428-04-3
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co | |
 |
2019-07-06 | Selonsertib
1448428-04-3
|
US $10.00 / KG/Tin | 1KG/Tin | 99% | 100 | Career Henan Chemical Co |
-
- Selonsertib
1448428-04-3
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
-
- Selonsertib
1448428-04-3
- US $10.00 / KG/Tin
- 99%
- Career Henan Chemical Co
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