Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Cinchonine

Cinchonine

Cinchonine Structure
Cinchonine structure
CAS No.
118-10-5
Chemical Name:
Cinchonine
Synonyms
Cinchonin;(+)-Cinchonine;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol;D-CINCHONINE;(+)-cinconine;NSC 6176;LA40221);CINCHONINE;Xin Kening;Xin Kenning
CBNumber:
CB0244972
Molecular Formula:
C19H22N2O
Molecular Weight:
294.39
MDL Number:
MFCD00064372
MOL File:
118-10-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

Cinchonine Properties

Melting point 260-263 °C
alpha 224 º (c=0.5, alcohol)
Boiling point 436.16°C (rough estimate)
Density 1.0863 (rough estimate)
bulk density 130kg/m3
vapor pressure 0Pa at 25℃
refractive index 223 ° (C=0.5, EtOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 0.25g/l
form Micro-Crystalline Powder
pka 5.85, 9.92(at 25℃)
color White to light beige
PH 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
optical activity [α]23/D +228°, c = 0.5 in ethanol
Water Solubility Insoluble
Sensitive Light Sensitive
Merck 14,2287
BRN 89689
Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChI 1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
InChIKey KMPWYEUPVWOPIM-QHQSXHFQSA-N
SMILES N21[C@H](C[C@@H]([C@H](C2)C=C)CC1)[C@@H](O)c3c4c(ncc3)cccc4
LogP 2.82 at 25℃
CAS DataBase Reference 118-10-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII V43X79NZCD
NIST Chemistry Reference Cinchonine(118-10-5)
EPA Substance Registry System Cinchonan-9-ol, (9S)- (118-10-5)
UNSPSC Code 12352104
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P261-P264-P270-P280-P301+P312-P302+P352
Hazard Codes  Xn
Risk Statements  20/22-20/21/22
Safety Statements  26-36-36/37
RIDADR  1544
WGK Germany  3
RTECS  GD3500000
F  8-34
TSCA  TSCA listed
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1
Toxicity LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
REACH Registrations Active
NFPA 704
1
2 1

Cinchonine price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL80963 (+)-Cinchonine phyproof? Reference Substance 118-10-5 100MG $247 2026-04-30 Buy
Sigma-Aldrich 8.02506 (+)-Cinchonine for resolution of racemates for synthesis 118-10-5 25g $87.5 2026-04-30 Buy
Sigma-Aldrich 8.02506 (+)-Cinchonine for resolution of racemates for synthesis 118-10-5 100g $259 2026-04-30 Buy
Sigma-Aldrich 27370 Cinchonine crystallized, ≥98.0% (NT) 118-10-5 25g $69 2026-04-30 Buy
Sigma-Aldrich 19431 (+)-Cinchonine analytical standard 118-10-5 50mg $443 2022-05-15 Buy
Product number Packaging Price Buy
PHL80963 100MG $247 Buy
8.02506 25g $87.5 Buy
8.02506 100g $259 Buy
27370 25g $69 Buy
19431 50mg $443 Buy

Cinchonine Chemical Properties, Uses, Production

Description

Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.

Chemical Properties

white to light yellow crystal powde

Uses

Stereomeric with Cinchonidine (C441925). Antimalarial.

Uses

cardiotonic

Uses

Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.

Definition

ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Health Hazard

The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]

Cinchonine Preparation Products And Raw materials

Raw materials

1-Azabicyclo[3.2.2]nonan-3-ol, 6-ethenyl-2-(4-quinolinyl)-, (1S,2R,3S,5S,6R)-

Preparation Products

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid QUININE SULFATE Hydrocinchonine (R)-(+)-2-Bromopropionic acid

Cinchonine Suppliers

Global Suppliers ( 451)
Supplier Tel Email Country ProdList Advantage
Shanghai Uteam Biotechnology Co., Ltd. 021-36031160 13311776681 3338195766@QQ.com China 5091 55
Shanghai Biological Technology Development Co., Ltd. 021-69955236-807 13918189704 chinaruji@chinaruji.com China 5093 55
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
xi'an renyang Biotechnology Co., Ltd. 13299086402 renyangbiotech@163.com China 93 58
Shanxi Yuning Biotechnology Co., Ltd. 13623677056 1039999500@qq.com China 519 58
BIOISCO(Lianyungang, Jiangsu) Biotechnology Co., Ltd 18082049515 2757382053@qq.com China 2995 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 0755-83725350 13380397412 3001280422@qq.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Supplier Advantage
Shanghai Uteam Biotechnology Co., Ltd. 55
Shanghai Biological Technology Development Co., Ltd. 55
Shanghai Qiao Chemical Science Co., Ltd 65
xi'an renyang Biotechnology Co., Ltd. 58
Shanxi Yuning Biotechnology Co., Ltd. 58
BIOISCO(Lianyungang, Jiangsu) Biotechnology Co., Ltd 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69

Related articles

View Latest Price from Cinchonine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cinchonine pictures 2026-10-15 Cinchonine
118-10-5
 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Cinchonine pictures 2026-07-27 Cinchonine
118-10-5
 $29.00 99.45% 10g TargetMol Chemicals Inc.
Cinchonine pictures 2026-07-27 Cinchonine
118-10-5
 $29.00 99.45% 10g TargetMol Chemicals Inc.
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • $0.00
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • $29.00
  • 99.45%
  • TargetMol Chemicals Inc.
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • $29.00
  • 99.45%
  • TargetMol Chemicals Inc.

Cinchonine Spectrum

Cinchonine(118-10-5)MSCinchonine(118-10-5)1HNMRCinchonine(118-10-5)IR1Cinchonine(118-10-5)IR2Cinchonine(118-10-5)Raman

118-10-5 (Cinchonine) Related Search:

Methanol N-Vinyl-2-pyrrolidone Triethoxyvinylsilane VINYL PROPIONATE Quinine
Vinyl acetate Vinylmagnesium bromide Cinchonidine CINCHONIDINE SULFATE Simvastatin ammonium salt
Simvastatin 4-(4-Chloro-benzyloxy)-phenylamine Cinchonine hydrochloride Cinchonine hydrochloride Silicone rubber,methyl-vinyl
Vinyl resin Vinyl ester resin Quinidine sulfate dihydrate

1of4

(8r,9s)-cinchonine (9s)-cinchonan-9-o (9S)-Cinchonan-9-ol CINCHONINE CINCHONAN-9-OL,(9S)- Cinchonine, 98+% Cinchonine dihydrate monohydrochloride Cinchonine Solution [for spray] (9S)-Cinconan-9-ol Cinchonine,99% (+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine Cinchonine ,98.5% (5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol 4-[(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)hydroxymethyl]quinoline (S)-{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol Cinchonine, 99% 100GR Cinchonine, 99% 25GR (+)-Cinchonine, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine Cinchonine, synthesis grade NSC 6176 (+)-CINCHONINE FOR RESOLUTION OF RACEMAT (1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)Methanol alpha-(5-vinyl-2-quinolyl)-2-quinuclidinemethano alpha-4-quinolyl-5-vinyl-2-quinuclidinemethano CINCHONINE FREE BASE CINCHONINE, CRYSTALLIZED CINCHONINE PURE Cinchonine (8CI) Cinchonine (base and/or unspecified salts) 4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol CINCHONINE:CINCHONAN-9-OL,(9S)-, (+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinidine CINCHONINE(P) CINCHONINE(RG) homocinchonidine homoquinidine Cinchonine , 98.0%(T) -Quinolin-4-yl(5-vinylquinuclidin-2-yl) Cinchonine (Synonyms: (8R,9S)-Cinchonine LA40221) [5-ethenyl-4-(2-quinolinyl)-1-azabicyclo[2.2.2]octan-2-yl]methanol Cinchonine(LA40221) Cinchonine ((8R,9S)-Cinchonine Xin Kenning Xin Kening Cinchonine > (S)-Quinolin-4-yl((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol Quinidine EP Impurity B 4-QUINOLYL(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)MET Cinchonine USP/EP/BP [(5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol CINCHONINE For Synthesis UNII-WTV8EPZ396 D-CINCHONINE (S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol Cinchonine monohydrochloride dihydrate (+)-Quinolin-4-yl(5-vinylquinuclidin-2-yl)methanol (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](quinolin-4-yl)methanol (cinchonine)