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Cinchonine

Cinchonine
Cinchonine structure
CAS No.
118-10-5
Chemical Name:
Cinchonine
Synonyms
LA40221);NSC 6176;Cinchonin;CINCHONINE;D-CINCHONINE;(+)-cinconine;CINCHONINE(P);homoquinidine;(+)-CINCHONINE;Cinchonine,99%
CBNumber:
CB0244972
Molecular Formula:
C19H22N2O
Formula Weight:
294.39
MOL File:
118-10-5.mol

Cinchonine Properties

Melting point:
260-263 °C
alpha 
224 º (c=0.5, alcohol)
Boiling point:
436.16°C (rough estimate)
Density 
1.0863 (rough estimate)
refractive index 
223 ° (C=0.5, EtOH)
storage temp. 
Store below +30°C.
solubility 
0.25g/l
form 
Micro-Crystalline Powder
pka
5.85, 9.92(at 25℃)
color 
White to light beige
PH
9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
optical activity
[α]23/D +228°, c = 0.5 in ethanol
Water Solubility 
Insoluble
Sensitive 
Light Sensitive
Merck 
14,2287
BRN 
89689
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey
KMPWYEUPVWOPIM-QHQSXHFQSA-N
CAS DataBase Reference
118-10-5(CAS DataBase Reference)
NIST Chemistry Reference
Cinchonine(118-10-5)
EPA Substance Registry System
Cinchonan-9-ol, (9S)-(118-10-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  20/22-20/21/22
Safety Statements  26-36-36/37
RIDADR  1544
WGK Germany  3
RTECS  GD3500000
8-34
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900
Toxicity LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P501 Dispose of contents/container to..…

Cinchonine price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 27370 Cinchonine crystallized, ≥98.0% (NT) 118-10-5 25g $44.7 2018-11-20 Buy
Sigma-Aldrich 19431 (+)-Cinchonine analytical standard 118-10-5 50mg $356 2018-11-13 Buy
TCI Chemical C0350 Cinchonine >98.0%(T) 118-10-5 25g $61 2018-11-22 Buy
TCI Chemical C0350 Cinchonine >98.0%(T) 118-10-5 200g $313 2018-11-22 Buy
Alfa Aesar A17523 (+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine 118-10-5 100g $98.7 2018-11-13 Buy

Cinchonine Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

cardiotonic

Uses

Stereomeric with Cinchonidine (C441925). Antimalarial.

Uses

Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.

Definition

ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Health Hazard

The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.

Purification Methods

Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]

Cinchonine Preparation Products And Raw materials

Raw materials

Preparation Products


Cinchonine Suppliers

Global( 223)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Kono Chem Co., Ltd
+86-132 8924 6953
info@konochemical.com CHINA 2164 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
ShangHai LanJi Science and Technology Development Co., Ltd. 021-56373608/66107288/13391393747
021-66107288 liujun@lanji.cn/QQ493513614 China 298 62
Shanghai Baoman Biotechnology Co., Ltd. 021-62130998
baomanbio@163.com China 5282 55
Shanghai Uteam Biotechnology Co., Ltd. 400-0909-005 021-69955236-807
021-69955236-807 lj80414@hotmail.com China 5191 55
Shanghai Biological Technology Development Co., Ltd. 400-0909-005 021-65211385-102
021-65211385 lj80414@hotmail.com China 5192 55

View Lastest Price from Cinchonine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Cinchonine
118-10-5
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-27 Cinchonine
118-10-5
US $29.00 / KG 10KG 99% 10000kg career henan chemical co

Cinchonine Spectrum


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