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Cinchonine

Cinchonine Structure
Cinchonine structure
CAS No.
118-10-5
Chemical Name:
Cinchonine
Synonyms
Cinchonin;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol;D-CINCHONINE;NSC 6176;LA40221);CINCHONINE;Xin Kening;Xin Kenning;Cinchoninne;(+)-cinconine
CBNumber:
CB0244972
Molecular Formula:
C19H22N2O
Molecular Weight:
294.39
MDL Number:
MFCD00064372
MOL File:
118-10-5.mol
MSDS File:
SDS
Last updated:2026-03-06 11:42:52
Product description Number Pack Size Price
(+)-Cinchonine phyproof? Reference Substance PHL80963 100MG $231
(+)-Cinchonine for resolution of racemates for synthesis 8.02506 25g $82.2
(+)-Cinchonine for resolution of racemates for synthesis 8.02506 100g $243
Cinchonine crystallized, ≥98.0% (NT) 27370 25g $64.8
(+)-Cinchonine analytical standard 19431 50mg $443
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Cinchonine Properties

Melting point 260-263 °C
alpha 224 º (c=0.5, alcohol)
Boiling point 436.16°C (rough estimate)
Density 1.0863 (rough estimate)
bulk density 130kg/m3
vapor pressure 0Pa at 25℃
refractive index 223 ° (C=0.5, EtOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 0.25g/l
form Micro-Crystalline Powder
pka 5.85, 9.92(at 25℃)
color White to light beige
PH 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
optical activity [α]23/D +228°, c = 0.5 in ethanol
Water Solubility Insoluble
Sensitive Light Sensitive
Merck 14,2287
BRN 89689
Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChI 1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
InChIKey KMPWYEUPVWOPIM-QHQSXHFQSA-N
SMILES N21[C@H](C[C@@H]([C@H](C2)C=C)CC1)[C@@H](O)c3c4c(ncc3)cccc4
LogP 2.82 at 25℃
CAS DataBase Reference 118-10-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII V43X79NZCD
NIST Chemistry Reference Cinchonine(118-10-5)
EPA Substance Registry System Cinchonan-9-ol, (9S)- (118-10-5)
UNSPSC Code 12352104
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P261-P264-P270-P280-P301+P312-P302+P352
Hazard Codes  Xn
Risk Statements  20/22-20/21/22
Safety Statements  26-36-36/37
RIDADR  1544
WGK Germany  3
RTECS  GD3500000
F  8-34
TSCA  TSCA listed
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1
Toxicity LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
NFPA 704
1
2 1

Cinchonine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL80963 (+)-Cinchonine phyproof? Reference Substance 118-10-5 100MG $231 2025-07-31 Buy
Sigma-Aldrich 8.02506 (+)-Cinchonine for resolution of racemates for synthesis 118-10-5 25g $82.2 2025-07-31 Buy
Sigma-Aldrich 8.02506 (+)-Cinchonine for resolution of racemates for synthesis 118-10-5 100g $243 2025-07-31 Buy
Sigma-Aldrich 27370 Cinchonine crystallized, ≥98.0% (NT) 118-10-5 25g $64.8 2025-07-31 Buy
Sigma-Aldrich 19431 (+)-Cinchonine analytical standard 118-10-5 50mg $443 2022-05-15 Buy
Product number Packaging Price Buy
PHL80963 100MG $231 Buy
8.02506 25g $82.2 Buy
8.02506 100g $243 Buy
27370 25g $64.8 Buy
19431 50mg $443 Buy

Cinchonine Chemical Properties,Uses,Production

Description

Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.

Chemical Properties

white to light yellow crystal powde

Uses

Stereomeric with Cinchonidine (C441925). Antimalarial.

Uses

cardiotonic

Uses

Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.

Definition

ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Health Hazard

The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]

Cinchonine Preparation Products And Raw materials

Raw materials

1-Azabicyclo[3.2.2]nonan-3-ol, 6-ethenyl-2-(4-quinolinyl)-, (1S,2R,3S,5S,6R)-

Preparation Products

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid QUININE SULFATE HYDROCINCHONINE (R)-(+)-2-BROMOPROPIONIC ACID

Cinchonine Suppliers

Global( 448)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8752 58
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 870 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21595 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Xianhe Biotech Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
Shenzhen Excellent Biotech Co., Ltd. 		58

Related articles

View Lastest Price from Cinchonine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cinchonine pictures 2026-03-06 Cinchonine
118-10-5
 US $10.00 / kg 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Cinchonine pictures 2026-03-05 Cinchonine
118-10-5
 US $29.00 / g 99.45% 10g TargetMol Chemicals Inc.
Cinchonine pictures 2026-03-05 Cinchonine
118-10-5
 US $29.00 / g 99.45% 10g TargetMol Chemicals Inc.
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • US $10.00 / kg
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • US $29.00 / g
  • 99.45%
  • TargetMol Chemicals Inc.
  • Cinchonine pictures
  • Cinchonine
    118-10-5
  • US $29.00 / g
  • 99.45%
  • TargetMol Chemicals Inc.

Cinchonine Spectrum

Cinchonine(118-10-5)MSCinchonine(118-10-5)1HNMRCinchonine(118-10-5)IR1Cinchonine(118-10-5)IR2Cinchonine(118-10-5)Raman

118-10-5(Cinchonine)Related Search:

Methanol N-Vinyl-2-pyrrolidone 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Triethoxyvinylsilane VINYL PROPIONATE
Quinine Vinyl acetate Vinylmagnesium bromide CINCHONINE HYDROCHLORIDE Cinchonidine
CINCHONINE HYDROCHLORIDE CINCHONIDINE SULFATE Simvastatin ammonium salt Simvastatin Silicone rubber,methyl-vinyl
Vinyl resin Vinyl ester resin CINCHONINE HEMISULFATE,CINCHONINE HEMISULFATE SALT,cinchonine sulphate,cinchonine,sulfate(2:1)(salt

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(+)-cinconine (8r,9s)-cinchonine (9s)-cinchonan-9-o (9S)-Cinchonan-9-ol CINCHONINE CINCHONAN-9-OL,(9S)- Cinchonine, 98+% Cinchonine dihydrate monohydrochloride Cinchonine Solution [for spray] (9S)-Cinconan-9-ol Cinchonine,99% (+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine Cinchonine ,98.5% (5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol 4-[(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)hydroxymethyl]quinoline (S)-{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol Cinchonine, 99% 100GR Cinchonine, 99% 25GR (+)-Cinchonine, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine Cinchonine, synthesis grade NSC 6176 (+)-CINCHONINE FOR RESOLUTION OF RACEMAT (1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)Methanol alpha-(5-vinyl-2-quinolyl)-2-quinuclidinemethano alpha-4-quinolyl-5-vinyl-2-quinuclidinemethano CINCHONINE FREE BASE CINCHONINE, CRYSTALLIZED CINCHONINE PURE Cinchonine (8CI) Cinchonine (base and/or unspecified salts) 4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol CINCHONINE:CINCHONAN-9-OL,(9S)-, (+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinidine CINCHONINE(P) CINCHONINE(RG) homocinchonidine homoquinidine Cinchonine , 98.0%(T) -Quinolin-4-yl(5-vinylquinuclidin-2-yl) Cinchonine (Synonyms: (8R,9S)-Cinchonine LA40221) [5-ethenyl-4-(2-quinolinyl)-1-azabicyclo[2.2.2]octan-2-yl]methanol Cinchonine(LA40221) Cinchonine ((8R,9S)-Cinchonine Xin Kenning Xin Kening Cinchonine > (S)-Quinolin-4-yl((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol Quinidine EP Impurity B 4-QUINOLYL(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)MET Cinchonine USP/EP/BP [(5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol CINCHONINE For Synthesis UNII-WTV8EPZ396 D-CINCHONINE Cinchonin (S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol Cinchonine monohydrochloride dihydrate