KX2-391
- CAS No.
- 897016-82-9
- Chemical Name:
- KX2-391
- Synonyms
- KX 01;CS-234;KX-O1);Tirbanibulin;KX2-391 (KX01);KX2-391 USP/EP/BP;Tirbanibulin, KX2-391;KX2-391（Tirbanibulin）;KX2-391;KX2 391;KX2391;N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
- CBNumber:
- CB02561484
- Molecular Formula:
- C26H29N3O3
- Molecular Weight:
- 431.53
- MDL Number:
- MFCD18633218
- MOL File:
- 897016-82-9.mol
| Boiling point | 680.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.169 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥121 mg/mL in DMSO; ≥2.44 mg/mL in EtOH with gentle warming and ultrasonic |
| form | Powder |
| pka | 14.73±0.46(Predicted) |
| FDA UNII | 4V9848RS5G |
| ATC code | D06BX03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
KX2-391 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21429 | KX2-391 ≥98% | 897016-82-9 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 21429 | KX2-391 ≥98% | 897016-82-9 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 21429 | KX2-391 ≥98% | 897016-82-9 | 50mg | $672 | 2024-03-01 | Buy |
| Cayman Chemical | 21429 | KX2-391 ≥98% | 897016-82-9 | 100mg | $1151 | 2024-03-01 | Buy |
| TRC | K475000 | KX2-391 | 897016-82-9 | 10mg | $255 | 2021-12-16 | Buy |
KX2-391 Chemical Properties,Uses,Production
Uses
A synthetic, orally bioavailable small molecule and non-ATP competitive Src tyrosine kinase inhibitor with an IC50 of average 72 nM.
Uses
KX2-391 is a Src Inhibitor with efficacy against certain hepatic and leukemia cell lines.
Biological Activity
kx2-391 is a highly selective inhibitor of src kinase with ic50 value of 20nm [1].kx2-391 is a non-atp competitive inhibitor of src. it is the first inhibitor that targets src kinase within the substrate binding site. kx2-391 inhibits src catalyzed trans-phosphorylation of fak, shc, paxillin as well as src kinase autophosphorylation. kx2-391 has no effects on pdgfr, egfr, jak1, jak2 and lck demonstrating it as a selective inhibitor. it is also found to be an inhibitor of tubulin polymerization through binding to the unique confirmation on heterodimeric tubulin. in cellular assays, kx2-391 shows growth inhibition in nih3t3/c-src527f cells and syf/c-src527f cells with gi50 values of 23nm and 39nm, respectively [1, 2].since src acts as a regulator in cell proliferation survival, motility and invasiveness, kx2-391 is potent against a variety of solid tumors and many leukemia tumors. it is shown to inhibit primary tumor growth and to suppress metastasis [2].
target
Src (HuH7)
References
[1] fallah-tafti a, foroumadi a, tiwari r, et al. thiazolyl n-benzyl-substituted acetamide derivatives: synthesis, src kinase inhibitory and anticancer activities. european journal of medicinal chemistry, 2011, 46(10): 4853-4858.
[2] naing a, cohen r, dy g k, et al. a phase i trial of kx2-391, a novel non-atp competitive substrate-pocket-directed src inhibitor, in patients with advanced malignancies. investigational new drugs, 2013, 31(4): 967-973.
KX2-391 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
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