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INSULIN

INSULIN
INSULIN structure
CAS No.
11070-73-8
Chemical Name:
INSULIN
Synonyms
ProMaxx;INSULIN;abs9169;27USP U/MG;insulin(ox);Insulin beef;bovineinsulin;INSULIN BOVINE;Insulin (cattle);Insulinfrombovine
CBNumber:
CB0336088
Molecular Formula:
C254H377N65O75S6
Formula Weight:
5733.49
MOL File:
Mol file

INSULIN Properties

storage temp. 
-20°C
solubility 
acidified water, pH 2.0: 2 mg/mL
form 
solution
Merck 
13,5003
Stability:
Stable. Incompatible with strong oxidizing agents. Keep refrigerated at -20 C
CAS DataBase Reference
11070-73-8
EWG's Food Scores
1
FDA UNII
576O9IZ534
NCI Dictionary of Cancer Terms
insulin
ATC code
A10AB02,A10AC02,A10AD02,A10AE02
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
RTECS  NM8900250
3-10

INSULIN price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I-035 Insulin from bovine pancreas solution 100?μg/mL (PBS pH 7.2), certified reference material, ampule of 0.5?mL, Cerilliant? 11070-73-8 0.5 mL $170 2021-03-22 Buy
Sigma-Aldrich 1342208 Insulin from bovine pancreas United States Pharmacopeia (USP) Reference Standard 11070-73-8 50mg $247 2020-08-18 Buy
Sigma-Aldrich I1882 Insulin from bovine pancreas 11070-73-8 100mg $499 2021-03-22 Buy
Sigma-Aldrich I6279 ProteoMass™ Insulin MALDI-MS Standard vial of 10?nmol, monoisotopic mol wt 5,729.6087?Da 11070-73-8 5 x 1 vial $227 2021-03-22 Buy
Sigma-Aldrich I6634 Insulin from bovine pancreas 11070-73-8 50mg $234 2021-03-22 Buy

INSULIN Chemical Properties,Uses,Production

Chemical Properties

white solid

Chemical Properties

Insulin is a relatively simple protein consisting of 51 amino acids arranged as two polypeptide chains, an α- chain and β-chain, connected by disulfide bonds; the latter are necessary to maintain tertiary structure and biological activity. Although the amino acid sequence and composition of animal insulins may differ slightly from those of human insulin, their biological actions are similar. Alteration of specific amino acid residues within the insulin molecule yields novel derivatives that vary in their pharmacokinetics and binding affinity for the insulin receptor. Some insulin analogues display mitogenic properties in addition to their metabolic effects.

Uses

Antidiabetic.

Definition

A polypeptide hormone having a molecular weight of 5733. It is formed in the islets of Langerhans located in the pancreas and was so named for this reason. Insulin is composed of 16 amino acids arranged in a coiled chain and crosslinked in several places

Indications

More than a century has passed since von Mering and Minkowski first demonstrated that pancreatectomized dogs exhibited signs and symptoms characteristic of diabetes mellitus. Shortly thereafter, Banting and Best used pancreatic extracts to reverse these symptoms in diabetic patients, thus providing a basis for establishing a cause-and-effect relationship between insulin deficiency and diabetes. Insulin was subsequently isolated, crystallized, and eventually synthesized in the laboratory. Insulin replacement therapy has been widely used in the clinical management of diabetes mellitus for more than 70 years. In 1982, recombinant DNA (rDNA) derived human insulin was first produced and is now widely used instead of insulin derived from beef or pork. More recently, insulin analogues have been produced that modulate the activity and rate of insulin action.

Hazard

Overdosage can be fatal.

Pharmacology

Insulin is usually administered subcutaneously. Depending on the type of insulin being administered, the rate of insulin absorption can be modulated by altering the polymerization of the insulin molecule (e.g., monomers, dimers, or hexamers). Intramuscular injections of insulin are used less often because absorption is more rapid. Being a polypeptide hormone, insulin is readily inactivated if administered orally. In emergencies, such as severe diabetic ketoacidosis, insulin can be given intravenously. Clinical studies are examining the efficacy and safety of inhaled insulin, which may be promising for some patients.
Once insulin enters the circulation, its plasma halflife is less than 10 minutes. Hepatic insulinases destroy approximately 50% of circulating insulin, with the remainder degraded by circulating proteases. Therefore, only a relatively small amount of the total endogenous insulin secreted ever reaches the peripheral tissues. Although a number of tissues accumulate small amounts of insulin, the liver and kidney are the principal sites of hormone uptake and degradation. Insulin metabolism is accomplished both through the actions of an insulinspecific protease found in the cytosol of many tissues and by the reductive cleavage of the insulin disulfide bonds by glutathione–insulin transhydrogenase. In the kidney, insulin that undergoes glomerular filtration is almost completely reabsorbed and metabolized within the proximal convoluted tubules of the nephron.

Clinical Use

According to the DCCT and the UK Prospective Diabetes study, insulin and/or insulin analogues are the standard treatment for type 1, gestational, and some type 2 diabetes.

Side effects

Insulin Overdose and Diabetic Coma The most common and serious reaction to insulin therapy is hypoglycemia. It is important that patients with diabetes, especially those receiving insulin therapy, be able to recognize the signs and symptoms of hypoglycemia. Symptoms of hypoglycemia may be evident with a plasma glucose level at 60 to 80 mg/dL. Severe hypoglycemia can lead to convulsions and coma. Patients that vigorously attempt to achieve euglycemia to avoid various vascular complications risk increased frequency of hypoglycemic episodes. In the DCCT, the incidence of severe hypoglycemic reactions was threefold higher in the intensive insulin therapy group than in the conventional therapy group.

Metabolism

Insulin degradation occurs primarily in the liver and kidney. Of that which is secreted from the pancreatic islet cells, 50% reaches the liver via the portal vein and undergoes disulfide bond cleavage catalyzed by glutathione insulin transhydrogenase (insulinase). This is followed by proteolytic degradation before entry into the general circulation. Insulin is filtered by the renal glomeruli and can then be reabsorbed or degraded by the tubules. At the tissue level, insulin degradation occurs to a limited extent at the cell surface.

INSULIN Preparation Products And Raw materials

Raw materials

Preparation Products


INSULIN Suppliers

Global( 141)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Career Henan Chemica Co
13203830695 0371-86658258
0371-86658258 Laboratory@coreychem.com CHINA 30290 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58

View Lastest Price from INSULIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-08 INSULIN USP/EP/BP
11070-73-8
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-07-09 INSULIN
11070-73-8
US $6650.00 / KG 1KG 98.0% 1T Shaanxi Dideu Medichem Co. Ltd
2018-07-11 Insulin(bovine pancreas)
11070-73-8
US $50.00 / MG 25MG 27U/mg 1kg Shanghai Zheyan Biotech Co., Ltd.

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