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1-Bromo-2-butyne

1-Bromo-2-butyne Structure
1-Bromo-2-butyne structure
CAS No.
3355-28-0
Chemical Name:
1-Bromo-2-butyne
Synonyms
1-Bromobut-2-yne;1-Bromobut-2-butyne;2-BUTYNYL BROMIDE;1-Brom-2-Butin;Linagliptin INT4;1-Bromo-2-butyne;1-Bromo-2-butynyl;1-broMo -2-Ding Que;1-Bromo-2-butyne99%;1-Bromo-2-butyne,98%
CBNumber:
CB0363349
Molecular Formula:
C4H5Br
Molecular Weight:
132.99
MDL Number:
MFCD00190233
MOL File:
3355-28-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:19
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1-Bromo-2-butyne Properties

Boiling point 40-41 °C/20 mmHg (lit.)
Density 1.519 g/mL at 25 °C (lit.)
refractive index n20/D 1.508(lit.)
Flash point 97 °F
storage temp. Inert atmosphere,Room Temperature
solubility Miscible with acetonitrile.
form Liquid
Specific Gravity 1.519
color Clear pale yellow-greenish
BRN 605306
InChI InChI=1S/C4H5Br/c1-2-3-4-5/h4H2,1H3
InChIKey LNNXOEHOXSYWLD-UHFFFAOYSA-N
SMILES C(Br)C#CC
CAS DataBase Reference 3355-28-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H226
Precautionary statements  P261-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Risk Statements  10
Safety Statements  16-24/25
RIDADR  UN 1993 3/PG 3
WGK Germany  3
F  10-23
HazardClass  3
PackingGroup  III
HS Code  29033990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
2 0

1-Bromo-2-butyne price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 427292 1-Bromo-2-butyne 99% 3355-28-0 1g $34.3 2026-04-30 Buy
Sigma-Aldrich 427292 1-Bromo-2-butyne 99% 3355-28-0 5g $158 2026-04-30 Buy
TCI Chemical B2190 1-Bromo-2-butyne >96.0%(GC) 3355-28-0 1g $32 2026-04-30 Buy
TCI Chemical B2190 1-Bromo-2-butyne >96.0%(GC) 3355-28-0 5g $88 2026-04-30 Buy
Usbiological 261615 1-Bromo-2-butyne Asreported 3355-28-0 250g $2718 2026-06-03 Buy
Product number Packaging Price Buy
427292 1g $34.3 Buy
427292 5g $158 Buy
B2190 1g $32 Buy
B2190 5g $88 Buy
261615 250g $2718 Buy

1-Bromo-2-butyne Chemical Properties, Uses, Production

Chemical Properties

Clear pale yellow-greenish liquid

Uses

1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.

Preparation

1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.

General Description

1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.

1-Bromo-2-butyne synthesis

764-01-2
7789-60-8
3355-28-0
Synthesis of 1-Bromo-2-butyne from 2-Butyn-1-ol and Phosphorus tribromide

1-Bromo-2-butyne Preparation Products And Raw materials

Raw materials

Preparation Products

1-Phthalimido-2-butyne 2-Butyn-1-amine, N-2-propyn-1-yl- Di-but-2-ynyl-amine 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

1-Bromo-2-butyne Suppliers

Global Suppliers ( 437)
Supplier Tel Email Country ProdList Advantage
Emeishan Hongsen Biopharmaceutical Co., Ltd. 0833-6186278 19162541913 sales@hongshengpharm.com China 99 60
Chengdu Maidisen Biotechnology Co., Ltd. 19981944287 info@cdmds.com China 111 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Anqing CHICO Pharmaceutical Co., Ltd. 18061456370 sales@chicopharm.com China 500 65
Nantong Subei Chemical Raw Materials Co., Ltd. 0513-85290972 18762756250 ntsbhg@163.com China 9277 58
Jiangsu Haici Biopharmaceutical Co., Ltd. 15722465851 15722465851 2545001360@qq.com China 183 58
Shanghai Newthink Biotechnology Co., Ltd. 18121861491 3847526528@qq.com China 107 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Emeishan Hongsen Biopharmaceutical Co., Ltd. 60
Chengdu Maidisen Biotechnology Co., Ltd. 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Sigma-Aldrich 80
Anqing CHICO Pharmaceutical Co., Ltd. 65
Nantong Subei Chemical Raw Materials Co., Ltd. 58
Jiangsu Haici Biopharmaceutical Co., Ltd. 58
Shanghai Newthink Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84

Related articles

View Latest Price from 1-Bromo-2-butyne manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-BROMO-2-BUTYNE pictures 2026-09-02 1-BROMO-2-BUTYNE
3355-28-0
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
1-BROMO-2-BUTYNE pictures 2026-08-21 1-BROMO-2-BUTYNE
3355-28-0
 $20.00-30.00 1kg 99% 20Tons Hebei Dangtong Import and export Co LTD
1-BROMO-2-BUTYNE pictures 2026-08-03 1-BROMO-2-BUTYNE
3355-28-0
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
  • 1-BROMO-2-BUTYNE pictures
  • 1-BROMO-2-BUTYNE
    3355-28-0
  • $20.00-30.00
  • 99%
  • Hebei Dangtong Import and export Co LTD

1-Bromo-2-butyne Spectrum

1-BROMO-2-BUTYNE(3355-28-0)MS1-BROMO-2-BUTYNE(3355-28-0)1HNMR1-BROMO-2-BUTYNE(3355-28-0)IR1

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1-BROMO-2-BUTYNE 98% 1-Bromo-2-butyne,98% But-2-yn-1-yl bromide 1-broMo -2-Ding Que 1-BroMo-2-butyne, 96.0%(GC) Linagliptin INT4 1-Bromo-2-butyne (Linagliptin) 1-BROMO-2-BUTYNE, 2-BUTYNYL BROMIDE 1-Brom-2-Butin Linagliptin intermediates，1-bromo-2-butyne 1-BROMO-2-BUTYNE ISO 9001：2015 REACH 1-Bromo-2-butyne > 1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98% 1-Bromobut-2-yne 95% 2-BUTYNYL BROMIDE Rilpivirine Impurity 18 1-Bromo-2-butynyl 1-Bromo-2-butyne99% 1-BROMO-2-BUTYNE Linagliptin I 1-Bromobut-2-yne 1-Bromobut-2-butyne 1-Bromo-2-butyne 3355-28-0 2563355-28-0 CH3CCCH2Br Br1C4H5 CH3C8801CCH2Br C4H5Br Organic Building Blocks Halogenated Hydrocarbons Acetylenes Functionalized Acetylenes Alkynyl Building Blocks Intermediates Acetylenes Functionalized Acetylenes Alkynyl Halogenated Hydrocarbons Organic Building Blocks