(Triisopropylsilyl)acetylene
- CAS No.
- 89343-06-6
- Chemical Name:
- (Triisopropylsilyl)acetylene
- Synonyms
- ETHYNYLTRIISOPROPYLSILANE;ethynyltris(propan-2-yl)silane;TIPS ACETYLENE;Triisopropylacetylene;(Triisopropylsilyl)acetylene,97%;DK423;DKSI047;DKFELEX0266;JACS-89343-06-6;Triisopropylsilylethyne
- CBNumber:
- CB0416001
- Molecular Formula:
- C11H22Si
- Molecular Weight:
- 182.38
- MDL Number:
- MFCD00075452
- MOL File:
- 89343-06-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (Triisopropylsilyl)acetylene 97% | 360031 | 5g | $118 |
| (Triisopropylsilyl)acetylene 97% | 360031 | 25g | $335 |
| Triisopropylsilylacetylene >95.0%(GC) | T1683 | 5mL | $69 |
| Triisopropylsilylacetylene >95.0%(GC) | T1683 | 25mL | $234 |
| TRIISOPROPYLSILYLACETYLEN | 83311 | 10g | $113.34 |
| More product size | |||
| Melting point | 50-51 °C |
|---|---|
| Boiling point | 50-52 °C/0.6 mmHg (lit.) |
| Density | 0.813 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 133 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Miscible with organic solvents. |
| form | liquid |
| color | Clear, colourless |
| Specific Gravity | 0.813 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 3536241 |
| InChI | InChI=1S/C11H22Si/c1-8-12(9(2)3,10(4)5)11(6)7/h1,9-11H,2-7H3 |
| InChIKey | KZGWPHUWNWRTEP-UHFFFAOYSA-N |
| SMILES | [Si](C#C)(C(C)C)(C(C)C)C(C)C |
| CAS DataBase Reference | 89343-06-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37/39 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | N | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
(Triisopropylsilyl)acetylene price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 360031 | (Triisopropylsilyl)acetylene 97% | 89343-06-6 | 5g | $118 | 2026-04-30 | Buy |
| Sigma-Aldrich | 360031 | (Triisopropylsilyl)acetylene 97% | 89343-06-6 | 25g | $335 | 2026-04-30 | Buy |
| TCI Chemical | T1683 | Triisopropylsilylacetylene >95.0%(GC) | 89343-06-6 | 5mL | $69 | 2026-04-30 | Buy |
| TCI Chemical | T1683 | Triisopropylsilylacetylene >95.0%(GC) | 89343-06-6 | 25mL | $234 | 2026-04-30 | Buy |
| GFS CHEMICALS | 83311 | TRIISOPROPYLSILYLACETYLEN | 89343-06-6 | 10g | $113.34 | 2021-12-16 | Buy |
(Triisopropylsilyl)acetylene Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Physical properties
colorless clear liquid; bp 50–52 °C at 0.8 hPa (0.6 mmHg), flash point 56 °C (closed cup); d = 0.813.
Uses
(Triisopropylsilyl)acetylene (TIPS-acetylene) is an easily handled and inexpensive monoprotected acetylene used as an attractive substitute for trimethylsilylacetylene (TMSacetylene). The bulkier silyl protecting group of TIPS-acetylene provides stability in a wider range of reaction conditions than TMS-acetylene. Its higher boiling point also provides better handling and safety than TMS-acetylene (bp 87–88°C at 12 hPa (9 mmHg)). The general utility of TIPS-acetylene is often highlighted in the transition metal-catalyzed C–C bond formations， including but not limited to transition metal-catalyzed Coupling Reactions；Reaction of TIPS-acetylide with Electrophiles；Synthesis of Polyynes；Transition Metal-catalyzed Cross-addition of TIPSacetylene to Alkynes；Hydroalkynylation；Direct Alkynylation；Conjugate Addition；Cycloaddition；Ring-opening Reactions etc.
Uses
(Triisopropylsilyl)acetylene may be used as reagent for the rhodium-catalyzed asymmetric alkynylation of various α,β-unsaturated ketones. It may be used as reagent in the enantioselective synthesis of β-alkynylated nitroalkanes.
Application
(Triisopropylsilyl)acetylene is often used in palladium-catalyzed Sonogashira coupling reactions to react with aryl halides to generate terminal alkynes. This reaction has good functional group compatibility and is suitable for later modification of drug molecules. It can be used for rhodium-catalyzed asymmetric alkynylation of α,β-unsaturated ketones to generate products with high stereoselectivity.
General Description
Asymmetric addition of (triisopropylsilyl)acetylene to α,β,γ,δ-unsaturated carbonyl compounds in the presence of a cobalt/Duphos catalyst is reported. A Sonogashira coupling reaction between 1-bromo-3-iodo-5-tertbutylbenzene and (triisopropylsilyl)acetylene is reported.
Synthesis
Triisopropylsilylacetylene can be prepared by a one-step reaction of triisopropylsilyl bromide with acetylene gas.
storage
(Triisopropylsilyl)acetylene (Ethynyltriisopropylsilane) is stable to air and moisture, incompatible with strong acids, bases, or oxidants, and flammable vapor and liquid. Skin/eye contact and inhalation should be avoided.
(Triisopropylsilyl)acetylene Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zhuangming Biopharma Co., Ltd. | inquiry@zmsilane.com | China | 728 | 58 | |
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | vcanam@vcanam.com | China | 49 | 58 |
| SHANDONG OUCHEM CO.,LTD. | +86-18506360988 | wtaili@ouchem.cn | China | 51 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
View Lastest Price from (Triisopropylsilyl)acetylene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | Triisopropylsilylacetylene
89343-06-6
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-12-01 | (Triisopropylsilyl)acetylene
89343-06-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-04-04 | (TRIISOPROPYLSILYL)ACETYLENE
89343-06-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Triisopropylsilylacetylene
89343-06-6
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (Triisopropylsilyl)acetylene
89343-06-6
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- (TRIISOPROPYLSILYL)ACETYLENE
89343-06-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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