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7-METHYL (1H)INDAZOLE

7-METHYL (1H)INDAZOLE Structure
7-METHYL (1H)INDAZOLE structure
CAS No.
3176-66-7
Chemical Name:
7-METHYL (1H)INDAZOLE
Synonyms
7-Methylindazole;7-Methyl-1H-indazol;7-METHYL (1H)INDAZOLE;1H-Indazole, 7-methyl-;7-methyl-1H-indazole(SALTDATA: FREE)
CBNumber:
CB0453370
Molecular Formula:
C8H8N2
Molecular Weight:
132.16
MDL Number:
MFCD05663434
MOL File:
3176-66-7.mol
Last updated:2026-01-13 11:11:04
Product description Number Pack Size Price
7-Methyl-1H-indazole Aldrich CBR00226 1g $179
7-Methyl-1H-indazole M313440 1g $195
7-Methyl-1H-indazole M313440 2.5g $275
7-Methyl-1H-indazole 98% OR928851 5g $355
7-Methyl-1H-indazole 037675 500mg $62
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7-METHYL (1H)INDAZOLE Properties

Melting point 158 °C
Boiling point 285.1±9.0 °C(Predicted)
Density 1.186±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder
pka 14.39±0.40(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C8H8N2/c1-6-3-2-4-7-5-9-10-8(6)7/h2-5H,1H3,(H,9,10)
InChIKey RLAZPAQEVQDPHR-UHFFFAOYSA-N
SMILES N1C2=C(C=CC=C2C)C=N1
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933998090
Storage Class 11 - Combustible Solids

7-METHYL (1H)INDAZOLE price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CBR00226 7-Methyl-1H-indazole Aldrich 3176-66-7 1g $179 2025-07-31 Buy
TRC M313440 7-Methyl-1H-indazole 3176-66-7 1g $195 2021-12-16 Buy
TRC M313440 7-Methyl-1H-indazole 3176-66-7 2.5g $275 2021-12-16 Buy
Apolloscientific OR928851 7-Methyl-1H-indazole 98% 3176-66-7 5g $355 2021-12-16 Buy
Matrix Scientific 037675 7-Methyl-1H-indazole 3176-66-7 500mg $62 2021-12-16 Buy
Product number Packaging Price Buy
CBR00226 1g $179 Buy
M313440 1g $195 Buy
M313440 2.5g $275 Buy
OR928851 5g $355 Buy
037675 500mg $62 Buy

7-METHYL (1H)INDAZOLE Chemical Properties,Uses,Production

Uses

7-Methyl-1H-indazole, can be used for the synthesis of 2-[(Heteroaryl)methyl]imidazolines, having activities at α1- and α2-adrenoceptors.

Synthesis

2,6-Dimethylaniline

87-62-7

7-METHYL (1H)INDAZOLE

3176-66-7

General procedure for the synthesis of 7-methyl-1H-indazole from 2,6-dimethylaniline: tert-butyl nitrite (52 mL) was slowly added to a solution of chloroform (750 mL) of 2,6-dimethylaniline (25 g, 206 mmol) at room temperature and protected by nitrogen, stirred for 20 min, then potassium acetate (40 g, 412 mmol) and 18-crown-6 ( 5.4 g, 20.6 mmol). The reaction mixture was heated to reflux for 3 hours, followed by cooling to room temperature and continued stirring for 15 hours. Upon completion of the reaction, the solids in the mixture were removed by vacuum filtration and the solids were washed with chloroform (400 mL). The filtrates were combined, washed with water (2 x 250 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography on silica gel, using hexane/ethyl acetate (9:1) as eluent to afford 7-methyl-1H-indazole as an orange solid (23 g, 85% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.60 (s, 3H), 7.10 (m, 2H), 7.70 (d, 1H), 8.10 (s, 1H).

References

[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 108-109
[2] Liebigs Annalen der Chemie, 1980, # 6, p. 908 - 927
[3] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270

7-METHYL (1H)INDAZOLE synthesis

87-62-7
3176-66-7
Synthesis of 7-METHYL (1H)INDAZOLE from 2,6-Dimethylaniline

7-METHYL (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

N-(2,6-dimethylphenyl)-N-nitroso-acetamide 1H-Indazole, 7-methyl-3-(trimethylsilyl)- Benzenediazonium, 2,6-dimethyl-, tetrafluoroborate(1-) Hydrazinecarboxylic acid, 2-(2,6-dimethylphenyl)-, ethyl ester 2-HYDROXY-3-METHYLBENZALDEHYDE
2',6'-DIMETHYLACETANILIDE Cyanuric acid Indazole 2,6-Dimethylaniline Iodomethane
2-Fluorotoluene Benzene Acetic acid

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Preparation Products

2,6-Diethylaniline

7-METHYL (1H)INDAZOLE Suppliers

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3999 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29837 58
Xiamen Shindano Biotechnology Co.,ltd 		0592-6266840 15750707980 sales@chemsdano.com China 291 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8645 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49958 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
career henan chemical co 		58
Xiamen Shindano Biotechnology Co.,ltd 		58
Alchem Pharmtech,Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Limited 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from 7-METHYL (1H)INDAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-METHYL (1H)INDAZOLE pictures 2024-07-08 7-METHYL (1H)INDAZOLE
3176-66-7
 US $1.00 / Kg 1Kg 98% 20T Shaanxi Dideu Medichem Co. Ltd
7-METHYL (1H)INDAZOLE pictures 2019-07-06 7-METHYL (1H)INDAZOLE
3176-66-7
 US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

7-METHYL (1H)INDAZOLE Spectrum

7-METHYL (1H)INDAZOLE(3176-66-7)1HNMR

3176-66-7(7-METHYL (1H)INDAZOLE)Related Search:

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7-METHYL (1H)INDAZOLE 7-Methylindazole 1H-Indazole, 7-methyl- 7-methyl-1H-indazole(SALTDATA: FREE) 7-Methyl-1H-indazol 3176-66-7 pharmacetical