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4-Iodopyrazole

4-Iodopyrazole structure

CAS No.: 3469-69-0

Chemical Name:: 4-Iodopyrazole

Synonyms: 4-IODO-1H-PYRAZOLE;4-Lodophrazole;4-IODOPYRAZOLE;4-LODO PYRAZOLE;4-iodopyrazole 4-;4-Iodopyrazole>4-IODOPYRAZOLE 99%;4 - iodine pyrazole;4-Iodopyrazole ,98%;1H-PYRAZOLE, 4-IODO-

CBNumber:: CB0456472

Molecular Formula:: C3H3IN2

Molecular Weight:: 193.97

MDL Number:: MFCD00005244

MOL File:: 3469-69-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:17

Product description	Number	Pack Size	Price
4-Iodopyrazole 99%	213993	10g	$97.3
4-Iodopyrazole >98.0%(GC)(T)	I0692	5g	$35
4-Iodopyrazole >98.0%(GC)(T)	I0692	25g	$123
4-Iodopyrazole	I719470	100g	$745
4-IODOPYRAZOLE 95.00%	HCH0023969	2.5G	$746.88
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4-Iodopyrazole Properties

Melting point	108-110 °C (lit.)
Boiling point	291.9±13.0 °C(Predicted)
Density	2.335±0.06 g/cm3(Predicted)
RTECS	UQ7145000
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	12.99±0.50(Predicted)
form	Crystalline Powder
color	White to off-white
Water Solubility	Soluble in water.
Sensitive	Light Sensitive
InChI	InChI=1S/C3H3IN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey	LLNQWPTUJJYTTE-UHFFFAOYSA-N
SMILES	N1C=C(I)C=N1
CAS DataBase Reference	3469-69-0(CAS DataBase Reference)
FDA UNII	F33UJD465Q
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

HazardClass

IRRITANT

HS Code

29331990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Iodopyrazole price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	213993	4-Iodopyrazole 99%	3469-69-0	10g	$97.3	2026-04-30	Buy
TCI Chemical	I0692	4-Iodopyrazole >98.0%(GC)(T)	3469-69-0	5g	$35	2026-04-30	Buy
TCI Chemical	I0692	4-Iodopyrazole >98.0%(GC)(T)	3469-69-0	25g	$123	2026-04-30	Buy
TRC	I719470	4-Iodopyrazole	3469-69-0	100g	$745	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0023969	4-IODOPYRAZOLE 95.00%	3469-69-0	2.5G	$746.88	2021-12-16	Buy

Product number	Packaging	Price	Buy
213993	10g	$97.3	Buy
I0692	5g	$35	Buy
I0692	25g	$123	Buy
I719470	100g	$745	Buy
HCH0023969	2.5G	$746.88	Buy

4-Iodopyrazole Chemical Properties,Uses,Production

Chemical Properties

White or off-white solid

Uses

4-Iodopyrazole was used in an indium-mediated synthesis of heterobiaryls.

Uses

4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.

Definition

ChEBI: 4-iodopyrazole is a member of pyrazoles and an organoiodine compound.

General Description

4-Iodopyrazole is a valuable intermediate for the synthesis of biologically active compounds. It undergoes iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole.

Synthesis

288-13-1

3469-69-0

The general procedure for the synthesis of 4-iodopyrazole from pyrazole is as follows: Example 1: Preparation of 2-amino-3-methyl-5-(1-methyl-1H-pyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)-3,5-dihydro-4H-imidazol-4-one Step a): Preparation of compound 2 A mixture of pyrazole (3.00 g, 44.0 mmol), iodine (6.71 g, 26.4 mmol) and ceric ammonium nitrate (14.5 g, 26.4 mmol) in acetonitrile (400 mL) was stirred at room temperature for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and partitioned between ethyl acetate (250 mL) and 5% aqueous sodium bisulfite (250 mL). After addition of water (150 mL), the organic layer was separated, washed with brine (250 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to afford compound 2 (7.80 g, 91% yield) as a white solid with a melting point of 105-108 °C. 1H NMR (300 MHz, CDCl3) δ 7.63 (s, 2H).

References

[1] Tetrahedron Letters, 2001, vol. 42, # 5, p. 863 - 865
[2] Heterocycles, 2003, vol. 60, # 4, p. 879 - 886
[3] Journal of Organic Chemistry, 2003, vol. 68, # 21, p. 8075 - 8079
[4] Tetrahedron Letters, 2001, vol. 42, # 11, p. 2089 - 2092
[5] Russian Chemical Bulletin, 2014, vol. 63, # 2, p. 360 - 367

4-Iodopyrazole synthesis

Synthesis of 4-Iodopyrazole from Pyrazole

4-Iodopyrazole Preparation Products And Raw materials

Raw materials

3,4-Diiodopyrazole 4-Bromopyrazole Pyrazole 1H-PYRAZOL-4-YLAMINE Acetonitrile

iodine Ceric ammonium nitrate

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Preparation Products

4-Iodo-1-methyl-1H-pyrazole 1-BENZYL-1H-PYRAZOLE 1-Benzyl-4-iodo-1H-pyrazole 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester 1-Butyl-4-iodo-1H-pyrazole

4-(2-(4-IODO-1H-PYRAZOL-1-YL)ETHYL)MORPHOLINE 1H-Pyrazole, 4-iodo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

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4-Iodopyrazole Suppliers

Global( 472)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from 4-Iodopyrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	4-Iodopyrazole 3469-69-0	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	4-iodopyrazole 3469-69-0	US $0.00-0.00 / KG	1KG	98%	1000KG	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	4-iodopyrazole 3469-69-0	US $8.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Iodopyrazole
3469-69-0
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-iodopyrazole
3469-69-0
US $0.00-0.00 / KG
98%
Shaanxi Dideu New Materials Co. Ltd

4-iodopyrazole
3469-69-0
US $8.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Iodopyrazole Spectrum

4-Iodopyrazole(3469-69-0)MS 4-Iodopyrazole(3469-69-0)¹HNMR 4-Iodopyrazole(3469-69-0)¹³CNMR 4-Iodopyrazole(3469-69-0)IR1 4-Iodopyrazole(3469-69-0)IR2 4-Iodopyrazole(3469-69-0)Raman

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4-IODOPYRAZOLE 1H-PYRAZOLE, 4-IODO- 4-IODOPYRAZOLE 99% 4-Iodopyrazole ,98% 4-Lodophrazole 4-LODO PYRAZOLE 4-Iodopyrazole, 97+% 4-Iodopyrazole 4-Iodo-1H-pyrazole 4 - iodine pyrazole 4-Iodo-1H-pyrazole 99% Crizotinib Impurity 14 4-iodopyrazole 4- 4-Iodopyrazole> 4-Iodopyrazole, 98%, for synthesis 4-IODO-1H-PYRAZOLE 3469-69-0 33469-69-0 3469-69-1 C3H3N2I C3H3IN2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrazoles HALOGEN Halides Pyrazoles & Triazoles Pyrazoles & Triazoles Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrazoles PyrazolesHeterocyclic Building Blocks Azoles blocks Iodides