VU0661013
- CAS No.
- 2131184-57-9
- Chemical Name:
- VU0661013
- Synonyms
- VU661013;VU0661013;1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-
- CBNumber:
- CB04845069
- Molecular Formula:
- C39H39Cl2N5O4
- Molecular Weight:
- 712.66
- MDL Number:
- MOL File:
- 2131184-57-9.mol
VU0661013 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A8783 | VU661013 | 2131184-57-9 | 5mg | $866 | 2021-12-16 | Buy |
| ApexBio Technology | A8783 | VU661013 | 2131184-57-9 | 10mg | $1339 | 2021-12-16 | Buy |
| ApexBio Technology | A8783 | VU661013 | 2131184-57-9 | 25mg | $2756 | 2021-12-16 | Buy |
| ApexBio Technology | A8783 | VU661013 | 2131184-57-9 | 50mg | $4331 | 2021-12-16 | Buy |
| DC Chemicals | DC12064 | VU0661013 >98% | 2131184-57-9 | 1g | $3600 | 2021-12-16 | Buy |
VU0661013 Chemical Properties,Uses,Production
Biological Activity
vu661013 is a novel, potent, selective mcl-1 inhibitor (ki of 97 ± 30 pm).[1]mcl-1, an anti-apoptotic bcl-2 family member, is commonly upregulated in acute myeloblastic leukemia (aml) cells. targeting anti-apoptotic proteins in aml is a key therapeutic strategy, and mcl-1 is a critical anti-apoptotic oncoprotein. [1]vu661013 reduced expansion of multiple aml cell lines in vitro. venetoclax (a bcl-2 inhibitor) and vu661013 exhibited favorable synergy in several of aml cells lines, venetoclax-resistant aml cells were sensitive to vu661013. [1]vu661013 decreased tumor growth in an in vivo murine model. vu661013 (25mg/kg) and venetoclax (15mg/kg) can be synergistic in patient-derived xenograft transplantation models. [1][1]a novel mcl-1 inhibitor combined with venetoclax rescues venetoclax resistant acute myelogenous leukemia. cancer discov. 2018 sep 5. pmid: 30185627. doi: 10.1158/2159-8290.cd-18-0140
VU0661013 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0661013 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Changyu Medical Technology Co. Ltd. | +86-13301875428 | sales@changyuhe.com | China | 289 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
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