VU0134992(hydrochloride)
- CAS No.
- 1052515-91-9
- Chemical Name:
- VU0134992(hydrochloride)
- Synonyms
- VU0134992 Hcl;VU0134992(hydrochloride);VU0134992 hydrochloride, 10 mM in DMSO;2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide hydrochloride;VU0134992,oral,hypertension,patch-clamp,electrophysiology,Kir4.1,VU 0134992,Inhibitor,natriuresis,inhibit,VU-0134992 hydrochloride,whole-cell,selective,kaliuresis,VU0134992 hydrochloride,Potassium Channel,KcsA,VU-0134992,diuresis
- CBNumber:
- CB76187218
- Molecular Formula:
- C20H32BrClN2O2
- Molecular Weight:
- 447.84
- MDL Number:
- MFCD05985784
- MOL File:
- 1052515-91-9.mol
| Product description | Number | Pack Size | Price |
| VU0134992 hydrochloride ≥98% (HPLC) | SML2431 | 5mg | $100 |
| VU0134992 hydrochloride ≥98% (HPLC) | SML2431 | 25mg | $406 |
| VU0134992 hydrochloride 99.57% | CS-0114959 | 100mg | $650 |
| VU0134992 hydrochloride 99.57% | CS-0114959 | 10mg | $125 |
| VU0134992 hydrochloride 99.57% | CS-0114959 | 5mg | $70 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
VU0134992(hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2431 | VU0134992 hydrochloride ≥98% (HPLC) | 1052515-91-9 | 5mg | $100 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2431 | VU0134992 hydrochloride ≥98% (HPLC) | 1052515-91-9 | 25mg | $406 | 2025-07-31 | Buy |
| ChemScene | CS-0114959 | VU0134992 hydrochloride 99.57% | 1052515-91-9 | 100mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0114959 | VU0134992 hydrochloride 99.57% | 1052515-91-9 | 10mg | $125 | 2021-12-16 | Buy |
| ChemScene | CS-0114959 | VU0134992 hydrochloride 99.57% | 1052515-91-9 | 5mg | $70 | 2021-12-16 | Buy |
VU0134992(hydrochloride) Chemical Properties,Uses,Production
Uses
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].
Biological Activity
VU0134992 is an orally available, potent and selective modulator of the inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) th at induces diuresis, natriuresis, and kaliuresis in rats.
in vivo
VU0134992 hydrochloride (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na+ as well as K+ excretion[1].
| Animal Model: | Male Sprague-Dawley rats (250-300 g)[1] |
| Dosage: | Oral gavage |
| Administration: | 50 and 100 mg/kg |
| Result: | Statistically significantly increased urinary Na+ as well as K+ excretion. |
References
[1] Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. DOI:10.1124/mol.118.112359
VU0134992(hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
VU0134992(hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 7906 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10503 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62220 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
View Lastest Price from VU0134992(hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-05 | VU0134992 hydrochloride
1052515-91-9
|
US $31.00-106.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-05 | VU0134992 hydrochloride
1052515-91-9
|
US $31.00-106.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. |
-
- VU0134992 hydrochloride
1052515-91-9
- US $31.00-106.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
-
- VU0134992 hydrochloride
1052515-91-9
- US $31.00-106.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
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