ChemicalBook >> CAS DataBase List >>N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

CAS No.
893990-34-6
Chemical Name:
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Synonyms
CS-1198;VU 0240551;CID 7211972;VU0240551-1;SID 56405457;VU0240551-2-D4;N-(4-Methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetaMide;N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide;Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-;N-(4-Methyl-thiazol-2-yl)-2-(6-phenyl-pyridazin-3-ylsulfanyl)-acetamide
CBNumber:
CB82518969
Molecular Formula:
C16H14N4OS2
Molecular Weight:
342.44
MDL Number:
MFCD05957363
MOL File:
893990-34-6.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Properties

Melting point 127 - 132°C
Density 1.39±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form powder
pka 7.59±0.50(Predicted)
color Pale Beige to Beige

SAFETY

Risk and Safety Statements

WGK Germany  3

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V3890 VU0240551 ≥98% (HPLC) 893990-34-6 5mg $229 2024-03-01 Buy
Sigma-Aldrich V3890 VU0240551 ≥98% (HPLC) 893990-34-6 25mg $781 2022-05-15 Buy
Cayman Chemical 29790 VU0240551 893990-34-6 5mg $78 2024-03-01 Buy
Cayman Chemical 29790 VU0240551 893990-34-6 50mg $543 2024-03-01 Buy
Cayman Chemical 29790 VU0240551 893990-34-6 10mg $132 2024-03-01 Buy
Product number Packaging Price Buy
V3890 5mg $229 Buy
V3890 25mg $781 Buy
29790 5mg $78 Buy
29790 50mg $543 Buy
29790 10mg $132 Buy

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Chemical Properties,Uses,Production

Description

VU0240551 is a K+/Cl- cotransporter 2 (KCC2) inhibitor (IC50 = 568 nM). It selectively inhibits KCC2 over Na+/K+/Cl- cotransporter 1 (NKCC1; IC50 = >50 μM) but does inhibit the activity of adenosine A1 and A3 receptors, as well as inhibits activity of L-type calcium channels at the benzothiazepine site and human ether-a-go-go-related gene (hERG) potassium channels by greater than 50% in a panel of 68 receptors, ion channels, and transporters at 10 μM. VU0240551 decreases potassium ion uptake by 70% in HEK293 cells expressing KCC2 when used at a concentration of 1 μM.

Uses

This molecule acts as an inhibitor of the K-Cl cotransporter KCC2, which is primarily responsible for maintaining intracellular Cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development.

Definition

ChEBI: N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide is a member of pyridazines and a ring assembly.

Biochem/physiol Actions

VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.

storage

Store at +4°C

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 55)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Amadis Chemical Company Limited
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EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU 0240551 N-(4-Methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetaMide CID 7211972 SID 56405457 VU0240551-1 VU0240551-2-D4 N-(4-Methyl-thiazol-2-yl)-2-(6-phenyl-pyridazin-3-ylsulfanyl)-acetamide CS-1198 Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- 893990-34-6