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Cetylpyridinium chloride

Cetylpyridinium chloride
Cetylpyridinium chloride structure
Chemical Name:
Cetylpyridinium chloride
Molecular Formula:
Formula Weight:
MOL File:

Cetylpyridinium chloride Properties

Melting point:
Boiling point:
496.25°C (rough estimate)
0.9362 (rough estimate)
refractive index 
1.6000 (estimate)
Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
White Crystalline Powder
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
123-03-5(CAS DataBase Reference)
EPA Substance Registry System
Pyridinium, 1-hexadecyl-, chloride(123-03-5)


RIDADR  2811
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 123-03-5(Hazardous Substances Data)

Cetylpyridinium chloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21983 Cetylpyridinium (chloride) ≥98% 123-03-5 100mg $25 2018-11-19 Buy
Cayman Chemical 21983 Cetylpyridinium (chloride) ≥98% 123-03-5 250mg $56 2018-11-19 Buy
Cayman Chemical 21983 Cetylpyridinium (chloride) ≥98% 123-03-5 1g $88 2018-11-19 Buy
Cayman Chemical 21983 Cetylpyridinium (chloride) ≥98% 123-03-5 5g $313 2018-11-19 Buy

Cetylpyridinium chloride Chemical Properties,Uses,Production

Chemical Properties

white powder or crystals with a pyridine-like odour

Chemical Properties

Cetylypyridinium chloride is a white powder with a characteristic odor. It is slightly soapy to the touch.


Antibacterial in cough lozenges and syrups; emulsifier.


ChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.

Production Methods

Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.

brand name

Ceepryn (Marion Merrell Dow); Cepacol (Marion Merrell Dow).

Pharmaceutical Applications

Cetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation,(1–3) although efficacy is variable owing to limited published data.

Clinical Use

1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.


Cetylpyridinium chloride is used widely in mouthwashes as a bactericidal antiseptic. It is generally regarded as a relatively nontoxic material when used at a concentration of 0.05% w/v, although minor side effects such as mild burning sensations on the tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage the mucous membranes in the mouth. It is harmful when ingested or inhaled. It can cause eye irritation, and is irritant to the respiratory system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg


Cetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.


Incompatible with strong oxidizing agents and bases. It is also incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride have been shown to significantly reduce its antimicrobial activity. This is due to the absorption of cetylpyridinium chloride on magnesium stearate. The cetylpyridinium chloride ion also interacts with gelatin, resulting in reduced bioavailability.

Regulatory Status

Included in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cetylpyridinium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Cetylpyridinium chloride Suppliers

Global( 176)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1730 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4669 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338 CHINA 1589 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 19923 58
Dishman Group 021-67121166-834
021-67121080 China 106 58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. 027-51831887 15337167856
027-51837635 QQ1165326703 China 10323 58

View Lastest Price from Cetylpyridinium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-13 Cetylpyridinium chloride
US $121.00 / KG 25KG 98% 1000KG career henan chemical co

Cetylpyridinium chloride Spectrum

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