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FASCAPLYSIN CHLORIDE

FASCAPLYSIN CHLORIDE Structure
FASCAPLYSIN CHLORIDE structure
CAS No.
114719-57-2
Chemical Name:
FASCAPLYSIN CHLORIDE
Synonyms
fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)
CBNumber:
CB0503495
Molecular Formula:
C18H11ClN2O
Molecular Weight:
306.74574
MDL Number:
MFCD09752600
MOL File:
114719-57-2.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:17
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FASCAPLYSIN CHLORIDE Properties

storage temp. 2-8°C
solubility Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
form solid
color Dark red-brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Hazard Codes  Xi,T
Risk Statements  36/37/38-61-45-20/21/22
Safety Statements  26-53-45-36/37/39

FASCAPLYSIN CHLORIDE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem 114719-57-2 1mg $140 2023-01-07 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 1mg $49 2024-03-01 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 5mg $193 2024-03-01 Buy
TRC F150013 FascaplysinChloride 114719-57-2 10mg $160 2021-12-16 Buy
Biorbyt Ltd orb573160 Fascaplysin (chloride)|CDK4 inhibitor 114719-57-2 1g $3580.2 2021-12-16 Buy
Product number Packaging Price Buy
341251 1mg $140 Buy
21715 1mg $49 Buy
21715 5mg $193 Buy
F150013 10mg $160 Buy
orb573160 1g $3580.2 Buy

FASCAPLYSIN CHLORIDE Chemical Properties,Uses,Production

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

References

1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377

FASCAPLYSIN CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FASCAPLYSIN CHLORIDE Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
BeiJing Hwrk Chemicals Limted 0757-86329057 18934348241 sales4.gd@hwrkchemical.com China 14067 55
BOC Sciences -- info@bocsci.com USA 0 65
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BeiJing Hwrk Chemicals Limted 55
BOC Sciences 65
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

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fascaplysine Fascaplysin chloride hydrate Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI) FASCAPLYSIN CHLORIDE Fascaplysin (chloride)|CDK4 inhibitor 12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride 114719-57-2 C18H11ClN2OxH2O C18H11ClN2O