LIPOXIN A4
- CAS No.
- 89663-86-5
- Chemical Name:
- LIPOXIN A4
- Synonyms
- LXA;LXA4;LIPOXIN A;LIPOXIN A4;LXA4, CID5280914;5(S),6(R)-LIPOXIN A4;5(S),6(R),15(S)-TRIHETE;Lipoxin A4 MaxSpecStandard;IXAQOQZEOGMIQS-SSQFXEBMSA-N;Lipoxin A - CAS 89663-86-5 - Calbiochem
- CBNumber:
- CB0687274
- Molecular Formula:
- C20H32O5
- Molecular Weight:
- 352.47
- MDL Number:
- MFCD00065845
- MOL File:
- 89663-86-5.mol
| Boiling point | 589.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.096±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | A solution in ethanol, can isomerize and degrade when put into freeze thaw conditions or in solvents such as DMSO, or DMF, 50 mg/ml in Ethanol, 1 mg/ml in PBS (pH 7.2) |
| form | ethanol solution |
| pka | 4.67±0.10(Predicted) |
| FDA UNII | F7C6J3D79J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 11 | |||||||||
| Safety Statements | 7-16 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
LIPOXIN A4 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L0521 | Lipoxin A4 ethanol solution | 89663-86-5 | 25μg | $1110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 437720 | Lipoxin A₄ - CAS 89663-86-5 - Calbiochem Lipoxin A?, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. | 89663-86-5 | 25μG | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 90410 | Lipoxin A4 ≥95% | 89663-86-5 | 25μg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 10007271 | Lipoxin A4 MaxSpec? Standard ≥95% | 89663-86-5 | 10μg | $242 | 2023-01-06 | Buy |
| Cayman Chemical | 90410 | Lipoxin A4 ≥95% | 89663-86-5 | 50μg | $382 | 2024-03-01 | Buy |
LIPOXIN A4 Chemical Properties,Uses,Production
Description
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (LTB4; Item Nos. 10007240 | 20110) in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.
LXA4 MaxSpec® standard is a quantitative grade standard of LXA4 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Uses
Lipoxin A4 is a trihydroxy fatty acid produced through 15-HETE metabolism.
Uses
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion. Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.
Definition
ChEBI: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-doubl bonds.
General Description
Caution! Product contains volatile liquid. Keep product cold at all times.
Biochem/physiol Actions
Lipoxin A4 (LXA4) is synthesized from arachidonic acid and is an endogenous lipoxygenase-derived eicosanoid mediator. It is a potent human protein kinase C activator. It inhibits cytotoxicity of natural killer cells. LXA4 regulates the immune system and inflammation. In the brain, it modulates neuronal signaling and slow wave sleep. LXA4 binds to cannabinoid receptors. LXA4 plays a key role in the maintenance of endometrium and reproductive function. Depletion of LXA4 contributes to the pathophysiology of cystic fibrosis (CF).
LIPOXIN A4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11732 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 6633 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 18080489829 | 3004654993@qq.com | China | 9209 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Shaanxi kelkai Pharmaceutical Technology Co., Ltd | 029-2148545164 17392779578 | 2148545164@qq.com | China | 6807 | 58 |
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