N,O-Bis(trimethylsilyl)hydroxylamine
- CAS No.
- 22737-37-7
- Chemical Name:
- N,O-Bis(trimethylsilyl)hydroxylamine
- Synonyms
- AKOS MSC-0143;Bis(trimethylsilyl)hydroxylamine;N,0-Bis(trimethylsilyl)hydroxylamine;O,N-Bis(trimethylsilyl)hydroxylamine;N,O-Bis(trimethylsilyl)hydroxylamine;N,O-Bis-(trimethylsilyl)-hydroxylamin;(Trimethylsiloxy)(trimethylsilyl)amine;N,O-Bis(trimethylsilyl)hydroxylamine >N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE, 97 %;[dimethyl-(trimethylsilyloxyamino)silyl]methane
- CBNumber:
- CB0779294
- Molecular Formula:
- C6H19NOSi2
- Molecular Weight:
- 177.39
- MDL Number:
- MFCD00008266
- MOL File:
- 22737-37-7.mol
- MSDS File:
- SDS
| Boiling point | 78-80 °C100 mm Hg(lit.) |
|---|---|
| Density | 0.83 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 84 °F |
| storage temp. | 2-8°C |
| solubility | sol THF, ether, pentane, CH2Cl2. |
| pka | 5.94±0.70(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.83 |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1920452 |
| InChI | 1S/C6H19NOSi2/c1-9(2,3)7-8-10(4,5)6/h7H,1-6H3 |
| InChIKey | ZAEUMMRLGAMWKE-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)NO[Si](C)(C)C |
| CAS DataBase Reference | 22737-37-7(CAS DataBase Reference) |
| Comptox DTXSID | DTXSID50177276 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 10-36/37/38-34 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319019 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 3 Skin Corr. 1B |
|||||||||
| NFPA 704 |
|
N,O-Bis(trimethylsilyl)hydroxylamine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 235105 | N,O-Bis(trimethylsilyl)hydroxylamine 97% | 22737-37-7 | 1g | $62 | 2023-01-07 | Buy |
| Sigma-Aldrich | 235105 | N,O-Bis(trimethylsilyl)hydroxylamine 97% | 22737-37-7 | 10g | $310 | 2022-05-15 | Buy |
| TCI Chemical | B1825 | N,O-Bis(trimethylsilyl)hydroxylamine >95.0%(GC) | 22737-37-7 | 5g | $583 | 2026-04-30 | Buy |
| Usbiological | 285898 | N,O-Bis(trimethylsilyl)hydroxylamine Asreported | 22737-37-7 | 1g | $368 | 2026-06-03 | Buy |
| Usbiological | 285898 | N,O-Bis(trimethylsilyl)hydroxylamine Asreported | 22737-37-7 | 2g | $516 | 2026-06-03 | Buy |
N,O-Bis(trimethylsilyl)hydroxylamine Chemical Properties, Uses, Production
Chemical Properties
Clear colorless liquid
Physical properties
bp 137–139°C, 78–80°C/100 mmHg; d 0.830 g cm3; flash point 28°C.
Uses
N,O-Bis(trimethylsilyl)hydroxylamine has been used as reagent for the preparation of N-(dialkyl phosphinoyl)hydroxylamines and migration of simple alkyl groups in rearrangement of their O-p-nitrobenzenesulfonates.
Uses
N,O-Bis(trimethylsilyl)hydroxylamine
is a protected, lipophilic form of hydroxylamine. It reacts
with a variety of electrophiles predominantly by attack on the nitrogen
nucleophilic center. Reaction with acid chlorides (1 equiv)
in the presence of triethylamine gives N,O-bis(trimethylsilyl)-
hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl)
hydroxylamine, gives the same product in high yields,
also by N-acylation.Hydrolysis gives the free hydroxamic
acids, whereas thermal fragmentation affords isocyanates (eq 1).
Preparation
N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating dry hydroxylamine with equiv chlorotrimethylsilane and equiv triethylamine.A safer preparation, which avoids the use of the explosive solid, hydroxylamine, uses the reaction of hydroxylamine hydrochloride with excess hexamethyldisilazane (71–75% yield).Alternatively, neutralization of hydroxylamine hydrochloride with ethylenediamine followed by addition of chlorotrimethylsilane can be used.
General Description
N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.
N,O-Bis(trimethylsilyl)hydroxylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44567 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Meishui Chemical Technology Co., Ltd | 021-60549325 18616193163 | China | 4518 | 56 |
View Latest Price from N,O-Bis(trimethylsilyl)hydroxylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
22737-37-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-31 | N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
22737-37-7
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
22737-37-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
22737-37-7
- $1.00
- 95-99%
- Career Henan Chemical Co
