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Amlodipine mesylate

Amlodipine mesylate Structure
Amlodipine mesylate structure
CAS No.
246852-12-0
Chemical Name:
Amlodipine mesylate
Synonyms
Amlodipine mesylate USP/EP/BP;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid;2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid3-ethyl ester5-methyl ester methanesulfonate
CBNumber:
CB11106917
Molecular Formula:
C20H25ClN2O5.CH4O3S
Molecular Weight:
0
MDL Number:
MFCD02682959
MOL File:
246852-12-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:04:12
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Amlodipine mesylate Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
FDA UNII 291Y33EZHA

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Amlodipine mesylate price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth WJA85212 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 246852-12-0 50mg $900 2026-06-05 Buy
Biosynth WJA85212 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 246852-12-0 500mg $900 2026-06-05 Buy
Biosynth WJA85212 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 246852-12-0 25mg $900 2026-06-05 Buy
Biosynth WJA85212 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 246852-12-0 250mg $900 2026-06-05 Buy
Biosynth WJA85212 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 246852-12-0 100mg $900 2026-06-05 Buy
Product number Packaging Price Buy
WJA85212 50mg $900 Buy
WJA85212 500mg $900 Buy
WJA85212 25mg $900 Buy
WJA85212 250mg $900 Buy
WJA85212 100mg $900 Buy

Amlodipine mesylate Chemical Properties, Uses, Production

Uses

Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3].

in vivo

Amlodipine mesylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].

Animal Model:ATP2B1loxP/loxP mice[4]
Dosage:5 mg/kg/day
Administration:Subcutaneously implanted osmotic pump for 2 weeks
Result:Significantly decreased the blood pressure.

IC 50

L-type calcium channel

References

[1] Kishen G. Bulsara, et al. Amlodipine.
[2] Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. DOI:10.2165/00003495-199550030-00009
[3] Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. DOI:10.1016/j.ejphar.2004.04.006
[4] Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. DOI:10.1038/hr.2017.92

Amlodipine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

Amlodipine mesylate Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6722 52
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Raw material medicin reagent co.,Ltd sales@njromanme.com China 4511 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
TOSUN PHARM 020-66392521-118 18922260391 3004261881@qq.com China 8003 58
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
Shaanxi Dideu Medichem Co. Ltd +86-29-81139210 +86-17392587031 1059@dideu.com China 9644 58
Hebei Chuanghai Biotechnology Co., Ltd +86-15350571055 Sibel@chuanghaibio.com China 8737 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49299 58
Shaanxi Dideu Medichem Co. Ltd 029-81154043 17391733319 1086@dideu.com China 9966 58
Supplier Advantage
XiaoGan ShenYuan ChemPharm co,ltd 52
Shanghai Kewel Chemical Co., Ltd. 50
Raw material medicin reagent co.,Ltd 58
Jiangsu aikang biomedical research and development co., LTD 58
TOSUN PHARM 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58
Hebei Chuanghai Biotechnology Co., Ltd 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58

View Latest Price from Amlodipine mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Amlodipine mesylate pictures 2026-05-21 Amlodipine mesylate
246852-12-0
 $2270.00-4000.00 10g TargetMol Chemicals Inc.
Amlodipine mesylate pictures 2026-03-20 Amlodipine mesylate
246852-12-0
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1 pictures 2024-04-25 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1
246852-12-0
 $50.00 1kg 99.10% 50000kg Ouhuang Engineering Materials (Hubei) Co., Ltd

246852-12-0 (Amlodipine mesylate) Related Search:

Amlodipine Amlodipine Besylate (S)-Amlodipine Amlodipine mesylate
3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid Amlodipine mesylate USP/EP/BP 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid3-ethyl ester5-methyl ester methanesulfonate 246852-12-0 C21H29ClN2O8S C20H25ClN2O5CH4O3S