Tiplaxtinin
- CAS No.
- 393105-53-8
- Chemical Name:
- Tiplaxtinin
- Synonyms
- PAI-039;CS-1464;tiplasinin;Tiplaxtinin;PAI 039 Tiplaxtinin;TIPLAXTININ(PAI-039);Tiplaxtinin >=98% (HPLC);Tiplaxtinin(PAI-039), >98%;TIPLAXTININ;PAI039;PAI 039;2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
- CBNumber:
- CB11261085
- Molecular Formula:
- C24H16F3NO4
- Molecular Weight:
- 439.38
- MDL Number:
- MFCD09475615
- MOL File:
- 393105-53-8.mol
- MSDS File:
- SDS
| Melting point | 164-167℃ |
|---|---|
| Density | 1.34 |
| storage temp. | -20°C |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | powder |
| color | white to beige |
| FDA UNII | L396QIB983 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312-H315-H318-H411 |
| Precautionary statements | P264-P270-P273-P280-P301+P312+P330-P302+P352+P312-P305+P351+P338+P310-P332+P313-P391-P501 |
Tiplaxtinin price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0295 | Tiplaxtinin ≥98% (HPLC) | 393105-53-8 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | PZ0295 | Tiplaxtinin ≥98% (HPLC) | 393105-53-8 | 25MG | $451 | 2023-06-20 | Buy |
| Cayman Chemical | 9000450 | Tiplaxtinin ≥98% | 393105-53-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 9000450 | Tiplaxtinin ≥98% | 393105-53-8 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 9000450 | Tiplaxtinin ≥98% | 393105-53-8 | 10mg | $142 | 2024-03-01 | Buy |
Tiplaxtinin Chemical Properties,Uses,Production
Description
Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.
Uses
Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.
Definition
ChEBI: Tiplasinin is a member of indole-3-acetic acids. It is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.
Biochem/physiol Actions
Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.
storage
Store at +4°C
Tiplaxtinin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9328 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from Tiplaxtinin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Tiplaxtinin
393105-53-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Tiplaxtinin
393105-53-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
![2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d pictures](https://img.chemicalbook.com/ProductImageEN/2019-9/Small/52a74ed7-749b-4502-bb97-fa685facc639.jpg) |
2019-09-06 | 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
393105-53-8
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- Tiplaxtinin
393105-53-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Tiplaxtinin
393105-53-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
393105-53-8
- US $1.00 / KG
- 98%
- Career Henan Chemical Co