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4'-Hydroxyacetophenone

4'-Hydroxyacetophenone Structure
4'-Hydroxyacetophenone structure
CAS No.
99-93-4
Chemical Name:
4'-Hydroxyacetophenone
Synonyms
4-HYDROXYACETOPHENONE;Piceol;P-HYDROXYACETOPHENONE;POB;P-HYDROXYBENZOPHENONE;ACETYLPHENOL;p-Acetylphenol;4-Hydroksyacetofenol;4-HYDROXYLACETOPHENONE;para-Hydroxyacetophenone
CBNumber:
CB7198612
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MDL Number:
MFCD00002359
MOL File:
99-93-4.mol
MSDS File:
SDS
Modify Date:2023-05-25
Request For Quotation

4'-Hydroxyacetophenone Properties

Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
Density 1.109
vapor pressure 0.002Pa at 20℃
refractive index 1.5577 (estimate)
FEMA 4330 | 4-HYDROXYACETOPHENONE
Flash point 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
pka 8.05(at 25℃)
color Almost white to beige
Specific Gravity 1.109
Odor at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa
Odor Type floral
Water Solubility 10 g/L (22 ºC)
JECFA Number 2040
BRN 774355
InChIKey TXFPEBPIARQUIG-UHFFFAOYSA-N
LogP 1.35 at 25℃
Substances Added to Food (formerly EAFUS) 4-HYDROXYACETOPHENONE
CAS DataBase Reference 99-93-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII G1L3HT4CMH
NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H412
Precautionary statements  P264-P273-P280-P305+P351+P338-P337+P313-P501
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  26-36/37-37/39-24/25-22-36
WGK Germany  3
RTECS  PC4959775
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
NFPA 704
1
2 0

4'-Hydroxyacetophenone price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 SAMPLE $50 2023-01-07 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 100G $150 2023-01-07 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 1KG $325 2023-01-07 Buy
Sigma-Aldrich PHL80232 4′-Hydroxyacetophenone phyproof? Reference Substance 99-93-4 100MG $250 2023-01-07 Buy
Sigma-Aldrich 8.04311 4′-Hydroxyacetophenone for synthesis 99-93-4 100g $57.2 2023-01-07 Buy
Product number Packaging Price Buy
W433055 SAMPLE $50 Buy
W433055 100G $150 Buy
W433055 1KG $325 Buy
PHL80232 100MG $250 Buy
8.04311 100g $57.2 Buy

4'-Hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

White to beige powder; sweet, hawthorn, balsam, mimosa aroma

Chemical Properties

almost white to beige crystalline powder

Occurrence

Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.

Uses

4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Uses

p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.

Uses

4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Definition

ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

Preparation

Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.

Aroma threshold values

Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Flammability and Explosibility

Nonflammable

Purification Methods

Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

4'-Hydroxyacetophenone synthesis

155853-28-4
99-93-4
Synthesis of 4'-Hydroxyacetophenone from Phenol, 4-(2-methyl-1,3-dithian-2-yl)-

4'-Hydroxyacetophenone Preparation Products And Raw materials

Raw materials

PHENYL ACETATE Aluminum chloride 2'-Hydroxyacetophenone 4-Aminoacetophenone

Preparation Products

4-QUINOXALIN-2-YLPHENOL Acetaminophen 4-Hydroxystyrene Atenolol 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE
4-Benzyloxy-3-nitroacetophenone 4-Hydroxyphenethyl alcohol 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone HPG 4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride
4-Acetoxystyrene 1,1,1-Tris(4-hydroxyphenyl)ethane Micafungin Side Chain Methyl Ester 3',5'-DICHLORO-4'-HYDROXYACETOPHENONE 4-HYDROXYBENZOYLACETIC ACID METHYL ESTER
4'-PIPERIDINOACETOPHENONE 2-(4-HYDROXYPHENYL)PROPIONIC ACID

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4'-Hydroxyacetophenone Suppliers

Global( 849)Suppliers
Supplier Tel Email Country ProdList Advantage
.GZ HONESTCHEM CO.,LTD
+86-15013270415 honestchemical@foxmail.com China 242 58
Shandong Believe Chemical PTE.LTD
+8618553607090 1093908296@qq.com China 1750 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29810 60
Henan DaKen Chemical CO.,LTD. 		+86-371-66670886 info@dakenchem.com China 18267 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21975 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 fandachem@gmail.com China 9407 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 31813 60
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2990 55
Tianjin Zhongxin Chemtech Co., Ltd. 		+86-022-66880623 +8618622897568 sales@tjzxchem.com China 548 58
Supplier Advantage
.GZ HONESTCHEM CO.,LTD
58
Shandong Believe Chemical PTE.LTD
58
Capot Chemical Co.,Ltd. 		60
Henan DaKen Chemical CO.,LTD. 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Hefei TNJ Chemical Industry Co.,Ltd. 		55
Tianjin Zhongxin Chemtech Co., Ltd. 		58

Related articles

View Lastest Price from 4'-Hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4＇-Hydroxyacetophenone pictures 2023-05-30 4＇-Hydroxyacetophenone
99-93-4
 US $0.00-0.00 / mg 10mg 99.21% 10g/month Guangzhou Tosun Pharmaceutical Limited
4'-Hydroxyacetophenone pictures 2023-05-30 4'-Hydroxyacetophenone
99-93-4
 US $45.00 / KG 1KG 98% 20t/month Hebei Yime New Material Technology Co., Ltd.
4'-Hydroxyacetophenone pictures 2023-05-30 4'-Hydroxyacetophenone
99-93-4
 US $45.00 / KG 1KG 98% 20t/month Hebei Yime New Material Technology Co., Ltd.

4'-Hydroxyacetophenone Spectrum

4'-Hydroxyacetophenone(99-93-4)MS4'-Hydroxyacetophenone(99-93-4)1HNMR4'-Hydroxyacetophenone(99-93-4)13CNMR4'-Hydroxyacetophenone(99-93-4)IR14'-Hydroxyacetophenone(99-93-4)IR24'-Hydroxyacetophenone(99-93-4)Raman

99-93-4(4'-Hydroxyacetophenone)Related Search:

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1-(4-hydroxyphenyl)-ethanon Hydroxyacetophenone, para HYDROXYACETOPHENONE-4 HYDROXYBENZOPHENONE-4 AKOS BBS-00003226 4-ACETOPHENOL 4-BENZOYLPHENOL 4'-HYDROXYACETOPHENONE 4-HYDROXYPHENYL METHYL KETONE 4'-Hydroxyacetophenone 4-Acetylphenol 4-HydraxyAcetophenone 4-HYDROXY ACETOPHENONE (p-HYDROXY ACETOPHENONE) 4'-Hydroxyacetophenone,99% PARA-METHYLKETOPHENOL PARA-ACETYLPHENOL Acetophenone,4'-hydroxy- D-Hydroxyacetophehone 4''-HYDROXYACETOPHENONESALBUTAMOL 4'-Hydroxyacetophenone,98% Methyl p-hydroxyphenyl ketone methyl-p-hydroxyphenylketone Phenol, p-acetyl- p-hydroxy-acetophenon p-Hydroxyphenyl methyl ketone p-hydroxyphenylmethylketone p-Oxyacetophenone USAF kf-15 usafkf-15 P-BENZOYLPHENOL P-ACETOPHENOL 1-(4-hydroxyphenyl)-1-ethanone HYDROXYACETOPHENONE, P- (RG) 4'-Hydroxyacetophene 4'-Hydroxyacetopheno Methyl 4-Hydroxyphenyl Ketone NSC 3698 p-Hydoxyacetophenone 4-Acetophenol 4-Acetylphenol 4-Hydroxyphenyl Methyl Ketone 4'-HYDROXYACETOPHENONE FOR SYNTHESIS Acetophenone, 4'-hydroxy- (6CI,8CI) Acetophenone, p-hydroxy- (3CI) ParacetaMol IMpurity E 1-(4-Hydroxyphenyl)ethan-1-one, 4-Acetylphenol The hydroxy acetophenone 4'-Hydroxyacetophenone> 1-(4-Hydroxyphenyl)ethanone (4-Hydr Paracetamol(Acetaminophen) EP Impurity E P-Hydroxy acetophenone -99% Factory supply 4'-Hydroxyacetophenone CAS 99-93-4 high quality Acetaminophen impurities1459 Acetaminophen EP Impurity E p-Hydroxy acetophenone, 98%+ Hydroxyce Tophenone Acetaminophen Impurity E 2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one Paracetamol EP Impurity E (4'-Hydroxyacetophenone) 4'-Hydroxyacetophenone IN STOCK 4'-Hydroxyacetophenone factory China