cannabidiol dimethyl ether
- CAS No.
- 1242-67-7
- Chemical Name:
- cannabidiol dimethyl ether
- Synonyms
- cannabidiol dimethyl ether;1-Methyl-3β-(2,6-dimethoxy-4-pentylphenyl)-4α-isopropenylcyclohexene;(3R)-1-Methyl-3β-(2,6-dimethoxy-4-pentylphenyl)-4α-isopropenyl-1-cyclohexene;(1R,6R)-1-(2,6-Dimethoxy-4-pentylphenyl)-3-methyl-6-isopropenyl-2-cyclohexene;Benzene, 1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-
- CBNumber:
- CB11385417
- Molecular Formula:
- C23H34O2
- Molecular Weight:
- 342.51
- MDL Number:
- MOL File:
- 1242-67-7.mol
| Boiling point | 438.4±45.0 °C(Predicted) |
|---|---|
| Density | 0.957±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤14mg/ml in ethanol;1mg/ml in DMSO;2mg/ml in dimethyl formamide |
| form | solution in acetate. |
| FDA UNII | MK7IHZ7MIM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
cannabidiol dimethyl ether price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13285 | Cannabidiol dimethyl ether ≥98% | 1242-67-7 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 13285 | Cannabidiol dimethyl ether ≥98% | 1242-67-7 | 5mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 13285 | Cannabidiol dimethyl ether ≥98% | 1242-67-7 | 10mg | $200 | 2021-12-16 | Buy |
| Cayman Chemical | 13285 | Cannabidiol dimethyl ether ≥98% | 1242-67-7 | 50mg | $875 | 2021-12-16 | Buy |
| ApexBio Technology | C3420 | Cannabidioldimethylether | 1242-67-7 | 10mg(solution) | $277 | 2021-12-16 | Buy |
cannabidiol dimethyl ether Chemical Properties,Uses,Production
Uses
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 μM. It does not inhibit 5-LO effectively (IC50 >200 μM).
Biological Activity
cannabidiol dimethyl ether (cbdd) is a cannabidiol derivative that potently and selectively inhibits 15-lox with an ic50 value of 0.28 μm.15-lox can oxygenate cholesterol esters in the low-density lipoprotein (ldl) particle. thus, 15-lox has been involved in the development of atherosclerosis, and cbdd may be a useful prototype for producing medicines for atherosclerosis [1].cbdd showed a potent inhibitory effect on the catalytic activity of cytochrome p450 2c19 with an ic50 value of 14.8 μμ [2]. cbdd inhibited the cyp2b6 activity with the ic50values of 75.7 μm [3]. cytochrome p450 enzymes have been isolated from numerous mammalian tissues such as liver, kidney, lung, intestine, adrenal cortex. cytochrome p450 enzymes have also existed in insects, plants, yeasts, and bacteria. cytochrome p450 has been known to catalyze hydroxylations, epoxidations, n-, s-, and o-dealkylations, n-oxidations, sulfoxidations, dehalogenations, and other reactions [4].
References
[1] takeda s, usami n, yamamoto i, et al. cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor[j]. drug metabolism and disposition, 2009, 37(8): 1733-1737.
[2] jiang r, yamaori s, okamoto y, et al. cannabidiol is a potent inhibitor of the catalytic activity of cytochrome p450 2c19[j]. drug metabolism and pharmacokinetics, 2013, 28(4): 332-338.
[3] yamaori s, maeda c, yamamoto i, et al. differential inhibition of human cytochrome p450 2a6 and 2b6 by major phytocannabinoids[j]. forensic toxicology, 2011, 29(2): 117-124.
[4] groves j t, han y z. models and mechanisms of cytochrome p450 action[m]//cytochrome p450. springer us, 1995: 3-48.
cannabidiol dimethyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
cannabidiol dimethyl ether Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| ApexBio Technology | 58 |