dolasetron
- CAS No.
- 115956-12-2
- Chemical Name:
- dolasetron
- Synonyms
- Hsdb 7565;DOLASETRON;Dolasteron;Dorasetron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Dolasetron, 10 mM in DMSO;Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
- CBNumber:
- CB12130500
- Molecular Formula:
- C19H20N2O3
- Molecular Weight:
- 324.37
- MDL Number:
- MFCD00865542
- MOL File:
- 115956-12-2.mol
| Product description | Number | Pack Size | Price |
| Dolasetron | D5820 | 10MG | $138 |
| Dolasetron | D5820 | 50MG | $415 |
| Dolasetron ≥98% | 22234 | 5mg | $49 |
| Dolasetron ≥98% | 22234 | 10mg | $77 |
| Dolasetron ≥98% | 22234 | 25mg | $179 |
| More product size | |||
| Melting point | 278 ºC |
|---|---|
| Boiling point | 535.1±50.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 15.36±0.30(Predicted) |
| color | White |
| Water Solubility | Soluble |
| CAS DataBase Reference | 115956-12-2 |
| FDA UNII | 82WI2L7Q6E |
| ATC code | A04AA04 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501 | |||||||||
| Hazardous Substances Data | 115956-12-2(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
dolasetron price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5820 | Dolasetron | 115956-12-2 | 10MG | $138 | 2025-07-31 | Buy |
| TCI Chemical | D5820 | Dolasetron | 115956-12-2 | 50MG | $415 | 2025-07-31 | Buy |
| Cayman Chemical | 22234 | Dolasetron ≥98% | 115956-12-2 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 22234 | Dolasetron ≥98% | 115956-12-2 | 10mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 22234 | Dolasetron ≥98% | 115956-12-2 | 25mg | $179 | 2024-03-01 | Buy |
dolasetron Chemical Properties,Uses,Production
Description
Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.
Chemical Properties
White Solid
Uses
prevention and treatment of postoperative nausea and vomiting
Uses
Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
Uses
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Definition
ChEBI: LSM-5418 is an indolyl carboxylic acid.
brand name
Anzemet (Sanofi Aventis.
References
[1] PETER H. BOEIJINGA . Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells[J]. European journal of pharmacology, 1992, 219 1: Pages 9-13. DOI: 10.1016/0014-2999(92)90573-m
[2] ROBERT C. MILLER. Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors[J]. Drug Development Research, 1993, 28 1: 87-93. DOI: 10.1002/ddr.430280111
dolasetron Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29846 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8025 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5992 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9209 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
View Lastest Price from dolasetron manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-11 | Dolasetron
115956-12-2
|
US $0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-10 | Dolasetron
115956-12-2
|
US $40.00-123.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Dolasetron
115956-12-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Dolasetron
115956-12-2
- US $0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dolasetron
115956-12-2
- US $40.00-123.00 / mg
- 99.84%
- TargetMol Chemicals Inc.
-
- Dolasetron
115956-12-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
115956-12-2(dolasetron)Related Search:
1of4
