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dolasetron

dolasetron structure

CAS No.: 115956-12-2

Chemical Name:: dolasetron

Synonyms: Hsdb 7565;DOLASETRON;Dolasteron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate;1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester

CBNumber:: CB12130500

Molecular Formula:: C19H20N2O3

Molecular Weight:: 324.37

MDL Number:: MFCD00865542

MOL File:: 115956-12-2.mol

Last updated:2023-06-08 09:03:09

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dolasetron Properties

Melting point	278 ºC
Boiling point	535.1±50.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
form	Solid
pka	15.36±0.30(Predicted)
color	White
Water Solubility	Soluble
CAS DataBase Reference	115956-12-2
FDA UNII	82WI2L7Q6E
ATC code	A04AA04

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501

NFPA 704

	0
3		0

dolasetron price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22234	Dolasetron ≥98%	115956-12-2	5mg	$49	2024-03-01	Buy
Cayman Chemical	22234	Dolasetron ≥98%	115956-12-2	10mg	$77	2024-03-01	Buy
Cayman Chemical	22234	Dolasetron ≥98%	115956-12-2	25mg	$179	2024-03-01	Buy
Cayman Chemical	22234	Dolasetron ≥98%	115956-12-2	50mg	$333	2024-03-01	Buy
ChemScene	CS-3747	Dolasetron >98.0%	115956-12-2	10mg	$192	2021-12-16	Buy

Product number	Packaging	Price	Buy
22234	5mg	$49	Buy
22234	10mg	$77	Buy
22234	25mg	$179	Buy
22234	50mg	$333	Buy
CS-3747	10mg	$192	Buy

dolasetron Chemical Properties,Uses,Production

Description

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 20 nM). It is selective for 5-HT₃ receptors over 5-HT_1A, 5-HT_1B, 5-HT₂, dopamine D₂, α₁-, α₂-, β-adrenergic, M_1-5 muscarinic acetylcholine, and neurokinin-1 (NK₁) receptors (IC₅₀s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC₅₀ = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

Chemical Properties

White Solid

Uses

prevention and treatment of postoperative nausea and vomiting

Uses

Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.

Uses

Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Definition

ChEBI: LSM-5418 is an indolyl carboxylic acid.

brand name

Anzemet (Sanofi Aventis.

dolasetron Preparation Products And Raw materials

Raw materials

Preparation Products

Suprofen

dolasetron Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Wuhan Fortuna Chemical Co., Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Sinoway Industrial co., ltd.	58
InvivoChem	58

View Lastest Price from dolasetron manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-02-16	Dolasetron 115956-12-2	US $0.00 / g	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13	Dolasetron 115956-12-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Dolasetron 115956-12-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Dolasetron
115956-12-2
US $0.00 / g
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Dolasetron
115956-12-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Dolasetron
115956-12-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

dolasetron Spectrum

dolasetron(115956-12-2)¹HNMR

115956-12-2(dolasetron)Related Search:

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(2a,6a,8a,9ab)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one 3-QUINUCLIDINONE CHEMBRDG-BB 4015185 1-(2-methylpiperidin-1-yl)acetone 2-CYCLOOCTYL-ETHYLAMINE

1-piperidinoacetone dolasetron Hexahydro-8-Hydroxy-2, 6-Methano-2h-Quinolizin-3(4h)-One

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(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate Dolasteron Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)- Dolasetronum Dolasetronum [inn-latin] Hsdb 7565 Unii-82wi2L7Q6e (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer DOLASETRON 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester dolasetron USP/EP/BP rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate 115956-12-2 API Heterocycles Intermediates & Fine Chemicals Pharmaceuticals