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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

CAS No.
915095-86-2
Chemical Name:
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyms
Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber:
CB12651407
Molecular Formula:
C13H7ClFIO
Molecular Weight:
360.55
MDL Number:
MFCD22665920
MOL File:
915095-86-2.mol
MSDS File:
SDS
Last updated:2024-08-29 17:54:24

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Properties

Melting point 64-70oC
Boiling point 415℃
Density 1.752
Flash point 205℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Ethyl Acetate
form Solid
color Off-White
InChI InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
HS Code  29142990

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C368575 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 2.5g $595 2021-12-16 Buy
AK Scientific 9597AF (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 100g $605 2021-12-16 Buy
Apolloscientific PC540099 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 98% 915095-86-2 100g $634 2021-12-16 Buy
Medical Isotopes, Inc. 91537 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 1g $725 2021-12-16 Buy
Apolloscientific PC540099 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 98% 915095-86-2 25g $224 2021-12-16 Buy
Product number Packaging Price Buy
C368575 2.5g $595 Buy
9597AF 100g $605 Buy
PC540099 100g $634 Buy
91537 1g $725 Buy
PC540099 25g $224 Buy

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Uses,Production

Uses

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthesis

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

462-06-6
19094-56-5
915095-86-2
Synthesis of (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone from Fluorobenzene and 2-Chloro-5-iodobenzoic acid

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials

Global( 221)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-23-86815286 +86-13983794297 sales@ensky-chemical.com China 91 58
Suzhou Nordica Biopharma CO.,LTD
+8618136148818 anna.ran@nordicabio.com China 298 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5873 58
Shanghai Joiny Pharmaceutical Co.,LTD
+8613681955282 gyd@joiny-pharma.com China 250 58
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571-85586718 +8613336195806 sales@capotchem.com China 29798 60
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+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21667 55
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0635-6175299 13961496334 sale@inyelchem.com CHINA 44 55
career henan chemical co
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View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2024-09-14 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
US $0.00 / kg 1kg 98% 500k Shanghai Joiny Pharmaceutical Co.,LTD
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2024-08-15 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2024-03-28 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
945065-86-2
US $0.00 / kg 25kg 98%-99% Inquiry PNP Biotech Co. Ltd
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)- (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone Empagliflozin Impurity 48 Englenet Impurity 16 2-chloro-4-fluoro-5-Iodobenzophenon (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon 2-Chloro-4'-fluoro-5-iodobenzophenone (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone Empagliflozin Impurity 48 /Englenet Impurity 16 2-Chloro-4'-fluoro-5-iodobenzophenone 915095-86-2 945065-86-2 C13H7ClFIO