KPT-330
- CAS No.
- 1393477-72-9
- Chemical Name:
- KPT-330
- Synonyms
- Selinexor;Xpovio;KPT-330;CS-1056;Aloradine;Selinexorb;KPT330; KPT 330;KPT330,Selinexor;KPT-330 USP/EP/BP;Selinexor (KPT-330)
- CBNumber:
- CB12681123
- Molecular Formula:
- C17H11F6N7O
- Molecular Weight:
- 443.31
- MDL Number:
- MFCD27987944
- MOL File:
- 1393477-72-9.mol
Density | 1.55±0.1 g/cm3(Predicted) |
---|---|
storage temp. | -20°C |
solubility | Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml) |
pka | 9.74±0.43(Predicted) |
form | solid |
color | Off-white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
NCI Dictionary of Cancer Terms | selinexor |
FDA UNII | 31TZ62FO8F |
NCI Drug Dictionary | selinexor |
ATC code | L01XX66 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H332-H302-H312 |
Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 |
KPT-330 price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18127 | KPT-330 ≥98% | 1393477-72-9 | 1mg | $29 | 2021-12-16 | Buy |
Cayman Chemical | 18127 | KPT-330 ≥98% | 1393477-72-9 | 5mg | $94 | 2021-12-16 | Buy |
Cayman Chemical | 18127 | KPT-330 ≥98% | 1393477-72-9 | 10mg | $160 | 2021-12-16 | Buy |
Cayman Chemical | 18127 | KPT-330 ≥98% | 1393477-72-9 | 50mg | $508 | 2021-12-16 | Buy |
Biorbyt Ltd | orb180928 | KPT-330(Selinexor) >98% | 1393477-72-9 | 100mg | $765 | 2021-12-16 | Buy |
KPT-330 Chemical Properties,Uses,Production
Description
Selinexor (1393477-72-9) is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1?and pancreatic cancer cells (IC50?~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8?Currently in clinical trials.
Uses
KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.
storage
Store at -20°C
References
1) Etchin?et al.?(2013),?KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-ALL and AML; Br. J. Haematol.?161?117 2) Azmi?et al. (2013),?Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice; Gastroenterology?144?447 3) Desisto?et al.?(2019),?Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma; Mol. Cancer Ther.?19 540 4) Aboukameel?et al. (2018),?Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression;?Oncotarget?9?35327 5) Baek?et al.?(2018),?XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies; Oncotarget?9?34567 6) Wahba?et al.?(2018),?The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and In Vivo; Mol. Cancer Ther.?17?1717 7) Arango?et al.?(2017),?Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer; Breast Cancer Res.?19?93 8) Conforti?et al.?(2017),?Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors; Cancer Res.?77?5614
KPT-330 Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24099 | 58 |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Related articles
- The introduction of KPT-330(Selinexor)
- Selinexor is a first-in-class, oral, small molecule Exportin-1 (XPO1) inhibitor that is being developed by Karyopharm Therapeu....
- Jan 23,2024
View Lastest Price from KPT-330 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-11-01 | Selinexor
1393477-72-9
|
US $0.00-0.00 / KG | 1KG | 99% | 200 | Hangzhou ICH Biofarm Co., Ltd | ||
2021-10-08 | Selinexor;KPT-330
1393477-72-9
|
US $0.00-0.00 / g | 1g | 98%+ | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | ||
2019-07-06 | KPT-330
1393477-72-9
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
- Selinexor
1393477-72-9
- US $0.00-0.00 / KG
- 99%
- Hangzhou ICH Biofarm Co., Ltd
- Selinexor;KPT-330
1393477-72-9
- US $0.00-0.00 / g
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
- KPT-330
1393477-72-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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